Abstract: Enhanced antisense oligonucleotides targeting Regulator of telomere elongation helicase 1 (RTEL1), leading to modulation of the expression of RTEL1 or modulation of RTEL1 activity are provided. This disclosure relates to the use of enhanced antisense oligonucleotides targeting RTEL1 for use in treating and/or preventing a hepatitis B virus (HBV) infection, in particular a chronic HBV infection. This disclosure further relates to the use of the enhanced antisense oligonucleotides targeting RTEL1 for destabilizing cccDNA, such as HBV cccDNA. A pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection is also described.

Abstract: The invention relates to a passenger car with a chassis, an engine (3, 103) and a vehicle axle, comprising a crossmember (1) connected to the chassis and two wheels movably connected laterally via a respective connection arrangement, wherein the wheels can be moved by the engine (3, 103) via the connection arrangement, and wherein a housing (6, 106) of the engine (3, 103) forms a transverse bridge of the crossmember (1) for transmitting transverse forces. According to the invention the crossmember (1) is fixed to the chassis via the housing (6, 106) of the engine (3).