Abstract: A W-shaped frangible seal line separating at least two chambers in a container or securing together two sheets of material. Outer legs of the W-shape preferably describe an angle of 170.degree. or less. Inner legs of the W-shape preferably describe an upside down chevron or V-shape that describes an acute angle.

Abstract: Apparatus for selectively mixing two components such as a powder and a liquid in a quick and efficient manner. The apparatus includes a compressible chamber with a liquid component therein, the compressible chamber including gas-trapping and reservoir compartments in open communication. Included is an arrangement to access the gas-trapping compartment such that the chamber may be connected to a container having a mixing component such as a powder therein so as to form a selectively opened pathway between the container and the compressible chamber of the apparatus. The apparatus may include the container. After the pathway is opened, the gas-trapping and reservoir compartments are selectively positioned to facilitate proper mixing of the liquid component in the chamber with the component in the container.

Abstract: A closed system for separately storing and selectively mixing two components, such as a drug and a diluent, under sterile conditions. The closed system can incorporate a drug vial of standard construction. A unique junction of the closed system permits a drug vial with a drug therein to be connected in a sterile manner with a compressible chamber having a diluent therein, after the drug and diluent have been separately sterilized. The junction encloses the end portions of access means to each of the receptacles, maintaining the end portions in sterile, spaced relation and providing for the selective establishment of a sterile pathway between the drug and diluent for mixing in a closed environment. The compressible chamber is of a unique design including gas-trapping and reservoir compartments in open communication. The compressible chamber is utilized with the junction to provide an efficient, sterile storage and mixing system.