Patents by Inventor Steffen Dickopf

Steffen Dickopf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC MULTISPECIFIC POLYPEPTIDES ACTIVATED BY POLYPEPTIDE CHAIN EXCHANGE
    Publication number: 20220041722
    Abstract: The present invention relates to a set of heterodimeric polypeptides and its uses in therapy, e.g. for treating cancer.
    Type: Application
    Filed: October 21, 2021
    Publication date: February 10, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich Brinkmann, Can Martin Buldun, Steffen Dickopf, Guy Georges, Sabine Imhof-Jung
  • ACTIVATABLE THERAPEUTIC MULTISPECIFIC POLYPEPTIDES WITH EXTENDED HALF-LIFE
    Publication number: 20220033526
    Abstract: The present invention relates to a set of heterodimeric polypeptides and its uses in therapy, e.g. for treating cancer.
    Type: Application
    Filed: October 21, 2021
    Publication date: February 3, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich Brinkmann, Steffen Dickopf
  • GENERATION OF ANTIBODY-DERIVED POLYPEPTIDES BY POLYPEPTIDE CHAIN EXCHANGE
    Publication number: 20220033525
    Abstract: The present invention relates to a set of heterodimeric polypeptides and its uses, e.g. for generating multispecific antigen binders by polypeptide chain exchange.
    Type: Application
    Filed: October 21, 2021
    Publication date: February 3, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich Brinkmann, Can Martin Buldun, Stefan Dengle, Steffen Dickopf, Guy Georges, Eike Hoffmann, Sabine Imhof-Jung, David Zilian
  • TRIFAB-CONTORSBODY
    Publication number: 20210122832
    Abstract: Herein is reported a multispecific antibody comprising two circular fusion polypeptides each of them comprising a VH/VL-pair and thereby a first and a second binding site, whereby a third VH/VL-pair and thereby a third binding site is formed by the associated of the two circular fusion polypeptides.
    Type: Application
    Filed: April 29, 2020
    Publication date: April 29, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich Brinkmann, Steffen Dickopf, Guy Georges, Irmgard Thorey
  • SPECIFICITY ASSAY FOR NOVEL TARGET ANTIGEN BINDING MOIETIES
    Publication number: 20210116455
    Abstract: The present invention generally relates to specificity assays using cell cultures, in particular to chimeric antigen receptor (CAR) expressing reporter T (CAR-T) cell assays to test novel target antigen binding moieties in different formats. Furthermore, the present invention relates to the use of reporter CAR-T cells, transfected/transduced with an engineered CAR capable of specific binding to a recognition domain comprising a tag.
    Type: Application
    Filed: August 31, 2020
    Publication date: April 22, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich BRINKMANN, Diana DAROWSKI, Steffen DICKOPF, Christian JOST, Christian KLEIN
  • METHOD FOR IN VIVO GENERATION OF MULTISPECIFIC ANTIBODIES FROM MONOSPECIFIC ANTIBODIES
    Publication number: 20200255522
    Abstract: Herein is reported a method for the generation of multispecific antibodies directly on the cell-surface at the site of action by a half-antibody exchange reaction between two 2/3-IgGs or two 2/3-BiFabs destabilized in one half by asymmetric perturbing mutations fostering the generation of correctly assembled full length bi- or multi-specific antibodies. The method is performed in the absence hinge region disulfide bonds in the starting 2/3-IgGs or 2/3-BiFabs.
    Type: Application
    Filed: April 28, 2020
    Publication date: August 13, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich Brinkmann, Klaus Mayer, Steffen Dickopf