Abstract: The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatibie macromolecule.

Abstract: A measuring device measures singlet oxygen luminescence which is excited by one or more photosensitizers. The measuring device contains a photosensitive detector, an excitation source, and a control and evaluating unit that is coupled to the photosensitive detector and the excitation source. The excitation source is configured to radiate excitation light into a measurement volume from a plurality of emission positions in order to excite the photosensitizer or photosensitizers. The excitation source preferably contains light-emitting diodes as lighting devices, the light of which is used directly as an excitation light in order to excite the photosensitizers.

Abstract: The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatibie macromolecule.

Abstract: A measuring device measures singlet oxygen luminescence which is excited by one or more photosensitizers. The measuring device contains a photosensitive detector, an excitation source, and a control and evaluating unit that is coupled to the photosensitive detector and the excitation source. The excitation source is configured to radiate excitation light into a measurement volume from a plurality of emission positions in order to excite the photosensitizer or photosensitizers. The excitation source preferably contains light-emitting diodes as lighting devices, the light of which is used directly as an excitation light in order to excite the photosensitizers.

Abstract: A method for enhanced Photodynamic Therapy (PDT) treatments by applying dendrimer-photosensitizer complexes to bring multiple photosensitizer moieties to a treatment site is provided. The most benefit is derived for treatments using systemic introduction of the photosensitizer formulation. Photosensitizers are covalently coupled to the peripheral bonding places of dendrimers, using labile bonds which are breakable in preference over bonding within either photosensitizer or dendrimer, and the photosensitizers are separated from the complexes in one or more successive cycles. Tetrapyrroles are the photosensitizers employed. In one embodiment the complex is also bound to an antibody or antibody fragment, which aids in targeting the complex to a desired treatment site. After introduction into a patient, the photosensitizers are controllably released, at the treatment site, from the complexes by either light, chemical, or a combined light/chemical effect.