Patents by Inventor Steffen Rupp
Steffen Rupp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11155578Abstract: A group of peptides is provided which activate or inhibit toll-like receptor 4 (TLR4) and may be used to modulate inflammatory signaling and host defense pathways. The peptides were derived in silico and tested in vitro in cell cultures. These peptides may be used in the preparation of immunomodulatory compositions such as vaccine adjuvants and in pharmaceutical compositions for immunomodulation of the innate immune system such as vaccine adjuvants. The peptides may also be used in the preparation of TLR4 activators, TLR4 inhibitors and MD2 labels, e.g., for research purposes.Type: GrantFiled: February 16, 2017Date of Patent: October 26, 2021Assignee: PEPTICOM LTD.Inventors: Amit Michaeli, Immanuel Lerner, Anke Burger-Kentischer, Steffen Rupp
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Publication number: 20200247849Abstract: A group of peptides is provided which activate or inhibit toll-like receptor 4 (TLR4) and may be used to modulate inflammatory signaling and host defense pathways. The peptides were derived in silico and tested in vitro in cell cultures. These peptides may be used in the preparation of immunomodulatory compositions such as vaccine adjuvants and in pharmaceutical compositions for immunomodulation of the innate immune system such as vaccine adjuvants. The peptides may also be used in the preparation of TLR4 activators, TLR4 inhibitors and MD2 labels, e.g., for research purposes.Type: ApplicationFiled: February 16, 2017Publication date: August 6, 2020Inventors: Amit MICHAELI, Immanuel LERNER, Anke BURGER-KENTISCHER, Steffen RUPP
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Patent number: 10613105Abstract: The invention relates to a competitive immunoassay test system as well as a method to simply and rapidly detect pyrogens contained in a sample by means of the pyrogen binding domain of pattern recognition receptors. The test system comprises an assay carrier having at least one immobilized pyrogen binding domain of a pattern recognition receptor with a labeled, displaceable ligand, wherein the displacement of the ligand is indicated by a pyrogen contained in the sample by a color reaction of the labeling. The assay carrier preferably also has at least one immobilized ligand capture protein, which binds the displaced ligand and thereby initiates a color reaction of the labeling.Type: GrantFiled: November 16, 2015Date of Patent: April 7, 2020Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Anke Burger-Kentischer, Steffen Rupp
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Publication number: 20180038841Abstract: The invention relates to a component, comprising a carrier made of a structurable material with at least one continues opening which is closed by a porous membrane, characterized in that the porous membrane protrudes from the surface of the component surrounding the continuous opening. In some embodiments, the component further comprises a carrier substrate, wherein a side of the carrier substrate which faces the component and the opposite side of the component preferably form a fluid channel, wherein the at least one continuous opening of the carrier preferably communicates on its open side with the fluid channel. The component according to the invention is suitable for the installation and electrochemical measuring of transmembrane proteins, preferably in lipid bilayers. The invention also proposes different methods for producing the component.Type: ApplicationFiled: October 21, 2015Publication date: February 8, 2018Inventors: Thomas LISEC, Eric NEBLING, Stefan KUBICK, Steffen RUPP
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Publication number: 20160327580Abstract: The invention relates to a competitive immunoassay test system as well as a method to simply and rapidly detect pyrogens contained in a sample by means of the pyrogen binding domain of pattern recognition receptors. The test system comprises an assay carrier having at least one immobilized pyrogen binding domain of a pattern recognition receptor with a labeled, displaceable ligand, wherein the displacement of the ligand is indicated by a pyrogen contained in the sample by a color reaction of the labeling. The assay carrier preferably also has at least one immobilized ligand capture protein, which binds the displaced ligand and thereby initiates a color reaction of the labeling.Type: ApplicationFiled: November 16, 2015Publication date: November 10, 2016Inventors: Anke BURGER-KENTISCHER, Steffen RUPP
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Patent number: 8876903Abstract: The invention relates to a multi-layered biological in vitro tissue containing: dermis layer, containing a collagen biomatrix with fibroblasts embedded therein and epidermis layer, containing epithelial cells. It is provided that latently virally infected neuronal cells are integrated at least into the dermis layer.Type: GrantFiled: June 2, 2011Date of Patent: November 4, 2014Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V.Inventors: Anke Burger-Kentischer, Ina Hogk, Doris Finkelmeier, Heike Walles, Steffen Rupp, Michaela Kaufmann
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Publication number: 20110300530Abstract: The invention relates to a multi-layered biological in vitro tissue containing: dermis layer, containing a collagen biomatrix with fibroblasts embedded therein and epidermis layer, containing epithelial cells. It is provided that latently virally infected neuronal cells are integrated at least into the dermis layer.Type: ApplicationFiled: June 2, 2011Publication date: December 8, 2011Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Anke BURGER-KENTISCHER, Ina Hogk, Doris Finkelmeier, Heike Walles, Steffen Rupp, Michaela Kaufmann
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Patent number: 8013121Abstract: The present invention concerns isolated collagen, the method for its production, and isolation of the collagen from collagen-containing tissues, as well as the use of the isolated collagen in a biomatrix as an in vitro test system, tissue replacement or organ replacement.Type: GrantFiled: May 30, 2007Date of Patent: September 6, 2011Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V.Inventors: Xin Xiong, Heike Mertsching, Steffen Rupp, Herwig Brunner
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Publication number: 20100216239Abstract: The present invention concerns isolated collagen, the method for its production, and isolation of the collagen from collagen-containing tissues, as well as the use of the isolated collagen in a biomatrix as an in vitro test system, tissue replacement or organ replacement.Type: ApplicationFiled: May 30, 2007Publication date: August 26, 2010Applicant: Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung V. Hansastrasse 26cInventors: Xin Xiong, Heike Mertsching, Steffen Rupp, Herwig Brunner
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Publication number: 20090156426Abstract: The present invention relates to functionalized porous carriers which comprise a material having at least one porous surface, nanoparticles having molecule-specific recognition sites being present in the pores of the material surface, and to a process for producing functionalized porous carriers. The invention further relates to functional elements produced using the functionalized carriers, such as microtiter plates, microarrays and flow devices, and also to uses of the functionalized carriers and functional elements.Type: ApplicationFiled: April 9, 2005Publication date: June 18, 2009Inventors: Thomas Schiestel, Steffen Rupp
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Publication number: 20080293079Abstract: The present invention concerns means and methods of detection of Candida and Candida-related fungal cells in clinical material by means of protein biochips.Type: ApplicationFiled: September 27, 2006Publication date: November 27, 2008Applicants: Frauhofer-Gesellschaft Zur Foerderung Der Angewandtten Forschung e.V., Universitaet StuttgartInventors: Nicole Hauser, Steffen Rupp, Achim Weber, Guenter Tovar, Ekkehard Hiller, Kirsten Borchers
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Publication number: 20080261209Abstract: The following invention relates to an improved method of quantitative or qualitative analysis of gene expression of a biological material.Type: ApplicationFiled: September 30, 2005Publication date: October 23, 2008Inventors: Kai Sohn, Steffen Rupp
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Publication number: 20070196378Abstract: Nucleic acids that code a cell wall protein required for the hyphal development of Candida; fragments of the nucleic acids; vectors containing the nucleic acids or nucleic acid fragments; host cells containing the vectors; cell wall proteins coded by the nucleic acids; antibodies directed against the proteins; methods for producing the cell wall proteins; methods for characterizing and/or for detecting the hyphal stage of Candida; methods for detecting a Candida infection; methods for identifying substances having a therapeutic effect against diseases caused by Candida; diagnostic and pharmaceutical compositions containing the nucleic acid, nucleic acids fragments, vectors, host cells, proteins and/or antibodies directed against the cell wall protein; kits for conducting in-vitro indentation of the cell wall proteins, and; to the use of the nucleic acids, vectors, proteins or antibodies for diagnosing and treating Candida-caused diseases, i.e., producing diagnostic or pharmaceutical compositions.Type: ApplicationFiled: March 15, 2005Publication date: August 23, 2007Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Henrike Lotz, Herwig Brunner, Steffen Rupp
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Patent number: 7220574Abstract: The present invention relates to biochips, in particular nucleotide chips, which contain hyphen-specific proteins coding nucleotides, protein chips which contain hyphen-specific proteins, and antibody chips which contain antibodies directed against these hyphen-specific proteins, diagnostic compositions which contain these nucleotide, protein, or antibody chips, processes for the location and identification of substances which are therapeutically effective against diseases caused by types of Candida and processes for the diagnosis of a disease caused by Candida.Type: GrantFiled: May 10, 2001Date of Patent: May 22, 2007Assignee: Fraunhafer-Gasellschaft zur Forderung der Angewandten Forschung E.V.Inventors: Steffen Rupp, Franz-Josef Johannes, Kai Sohn
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Publication number: 20050048570Abstract: The present invention relates to functional elements that comprise microstructures containing biofunctionalized nanoparticles arranged on a carrier, a method for the production of these functional elements and the use thereof.Type: ApplicationFiled: December 27, 2002Publication date: March 3, 2005Inventors: Achim Weber, Thomas Schiestel, Gunter Tovar, Herwig Brunner, Steffen Rupp, Nicole Hauser
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Publication number: 20040044193Abstract: The present invention relates to nucleotide sequences which code for proteins modulating the virulence of pathogenic fungal strains; vectors which contain these sequences; host cells which have these nucleotide sequences or vectors; proteins modulating the virulence of pathogenic fungal strains, in particular the transcription factor CaTEC1 of Candida albicans; inhibitors thereof, particularly antibodies which are directed against these virulence-modulating proteins; methods for the production of the proteins and inhibitors; methods for the diagnosis and therapy of diseases which are connected with a Candida infection; and also diagnostic and pharmaceutical compositions which contain the nucleotide sequences, proteins, host cells and/or antibodies.Type: ApplicationFiled: August 19, 2003Publication date: March 4, 2004Inventors: Klaus Schroppel, Brad N. Taylor, Anja Schweizer, Steffen Rupp
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Publication number: 20040023907Abstract: This present invention relates to means and methods for analyzing and diagnosing infections in humans or animals caused by pathogenic and/or parasitic microorganisms, means and methods for analyzing and diagnosing degenerated or genetically engineered human or animal cells, as well as means and methods for investigating and testing anti-infective agents and medications against tumors, as well as three-dimensional in vitro organ and tissue models, in particular of tissues susceptible for infections, such as intestines, skin, cornea, trachea, and mucous membranes.Type: ApplicationFiled: August 8, 2003Publication date: February 5, 2004Inventors: Christoph Dieterich, Steffen Rupp, Michaela Noll, Thomas Graeve
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Publication number: 20040014061Abstract: The present invention relates to biochips, in particular nucleotide chips, which contain hyphen-specific proteins coding nucleotides, protein chips which contain hyphen-specific proteins, and antibody chips which contain antibodies directed against these hyphen-specific proteins, diagnostic compositions which contain these nucleotide, protein, or antibody chips, processes for the location and identification of substances which are therapeutically effective against diseases caused by types of Candida and processes for the diagnosis of a disease caused by Candida.Type: ApplicationFiled: July 2, 2003Publication date: January 22, 2004Inventors: Steffen Rupp, Franz-Josef Johannes, Kai Sohn
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Publication number: 20030235857Abstract: Disclosed herein are methods for regulating fungal gene expression, and reagents for carrying out those methods.Type: ApplicationFiled: June 4, 2003Publication date: December 25, 2003Applicant: Whitehead Institute for BioMedical Research, a Delaware corporationInventors: Steffen Rupp, Laura Robertson, Eric F. Summers, Peter Hecht, Radclyffe Roberts, Hiten Madhani, Cora Ann Styles, Hsiu-Jung Lo, Amir Sherman, Brian Cali, Gerald R. Fink
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Patent number: 6599705Abstract: Disclosed herein are methods for regulating fungal gene expression, and reagents for carrying out those methods.Type: GrantFiled: May 22, 2001Date of Patent: July 29, 2003Assignee: The Whitehead Institute for Biomedical ResearchInventors: Steffen Rupp, Laura Robertson, Eric F. Summers, Peter Hecht, Radclyffe Roberts, Hiten Madhani, Cora Ann Styles, Hsiu-Jung Lo, Amir Sherman, Brian Cali, Gerald R. Fink