Patents by Inventor Stella Sarraf

Stella Sarraf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHOSPHATE COMPOUNDS FOR DETECTING NEUROLOGICAL DISORDERS
    Publication number: 20240033380
    Abstract: Provided herein are compounds, methods and compositions for determining whether a patient has a neurological disease or disorder is provided, comprising detecting the presence of a detectable target protein, or an accumulated mass thereof, for example, amyloid beta protein or phosphorylated tau protein, or an accumulated mass thereof, in a tissue or a sample of the patient. The detecting may comprise contacting the target protein with a compound described herein.
    Type: Application
    Filed: March 30, 2023
    Publication date: February 1, 2024
    Inventors: Stella Sarraf, Lyndsay M. Randolph, Suhail Rasool
  • Amyloid targeting agents and methods of using the same
    Patent number: 11718596
    Abstract: Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.
    Type: Grant
    Filed: February 9, 2021
    Date of Patent: August 8, 2023
    Assignees: The Regents of the University of California, Amydis, Inc.
    Inventors: Jerry Yang, Emmanuel A. Theodorakis, Stella Sarraf
  • METHODS OF DETECTING NEUROLOGICAL DISORDERS VIA BINDING TO PHOSPHORYLATED TAU PROTEIN
    Publication number: 20220370642
    Abstract: Provided herein are methods and compositions for determining whether a patient suffers from a neurological disease or disorder is provided, comprising detecting the presence of a phosphorylated tau protein in a tissue of the patient, wherein the detecting comprises contacting the phosphorylated tau protein with a compound described herein.
    Type: Application
    Filed: September 17, 2020
    Publication date: November 24, 2022
    Inventors: Stella Sarraf, Suhail Rasool
  • BENZOTHIAZOLE AND RELATED COMPOUNDS
    Publication number: 20220017477
    Abstract: Disclosed are compounds that promote spinogenesis, are capable of reducing the neural toxicity of beta-amyloid peptides, and/or reduce the symptoms of traumatic brain injury in a patient.
    Type: Application
    Filed: August 2, 2021
    Publication date: January 20, 2022
    Inventors: Stella Sarraf, Vincent F. Simmon, Gerald F. Swiss
  • PHOSPHATE COMPOUNDS FOR DETECTING NEUROLOGICAL DISORDERS
    Publication number: 20220001033
    Abstract: Provided herein are compounds, methods and compositions for determining whether a patient has a neurological disease or disorder is provided, comprising detecting the presence of a detectable target protein, or an accumulated mass thereof, for example, amyloid beta protein or phosphorylated tau protein, or an accumulated mass thereof, in a tissue or a sample of the patient. The detecting may comprise contacting the target protein with a compound described herein.
    Type: Application
    Filed: November 1, 2019
    Publication date: January 6, 2022
    Inventors: Stella Sarraf, Lyndsay M. Randolph, Suhail Rasool
  • AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME
    Publication number: 20210371390
    Abstract: Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.
    Type: Application
    Filed: February 9, 2021
    Publication date: December 2, 2021
    Inventors: Jerry Yang, Emmanuel A. Theodorakis, Stella Sarraf
  • COMPOSITIONS AND METHODS FOR DETECTION OF TRAUMATIC BRAIN INJURY
    Publication number: 20210369873
    Abstract: The present disclosure relates generally to compositions and methods for determining whether a patient suffers from a traumatic brain injury (TBI) by detecting the presence of an amyloid beta protein in an eye of the patient. Also provided are compositions and methods for preparing a patient for diagnosis and treatment of traumatic brain injury (TB).
    Type: Application
    Filed: May 31, 2019
    Publication date: December 2, 2021
    Inventors: Stella Sarraf, Lyndsay M. Randolph, Suhail Rasool
  • Benzothiazole and related compounds
    Patent number: 11117878
    Abstract: Disclosed are compounds that promote spinogenesis, are capable of reducing the neural toxicity of beta-amyloid peptides, and/or reduce the symptoms of traumatic brain injury in a patient.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: September 14, 2021
    Assignee: Spinogenix, Inc.
    Inventors: Stella Sarraf, Vincent F. Simmon, Gerald F. Swiss
  • Amyloid targeting agents and methods of using the same
    Patent number: 10934264
    Abstract: Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: March 2, 2021
    Assignees: The Regents of the University of California, Amydis, Inc.
    Inventors: Jerry Yang, Emmanuel A. Theodorakis, Stella Sarraf
  • BENZOTHIAZOLE AND RELATED COMPOUNDS
    Publication number: 20200157068
    Abstract: Disclosed are compounds that promote spinogenesis, are capable of reducing the neural toxicity of beta-amyloid peptides, and/or reduce the symptoms of traumatic brain injury in a patient.
    Type: Application
    Filed: August 1, 2018
    Publication date: May 21, 2020
    Inventors: Stella Sarraf, Vincent F. Simmon, Gerald F. Swiss
  • AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME
    Publication number: 20200123118
    Abstract: Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.
    Type: Application
    Filed: October 23, 2019
    Publication date: April 23, 2020
    Inventors: Jerry Yang, Emmanuel A. Theodorakis, Stella Sarraf
  • Amyloid targeting agents and methods of using the same
    Patent number: 10370345
    Abstract: Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: August 6, 2019
    Assignees: The Regents of the University of California, Amydis Diagnostics, Inc.
    Inventors: Jerry Yang, Emmanuel A. Theodorakis, Stella Sarraf
  • AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME
    Publication number: 20180327373
    Abstract: Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.
    Type: Application
    Filed: May 2, 2018
    Publication date: November 15, 2018
    Inventors: Jerry Yang, Emmanuel A. Theodorakis, Stella Sarraf
  • Amyloid targeting agents and methods of using the same
    Patent number: 10005745
    Abstract: Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are the methods for treating of diseases associated with an amyloid or amyloid like proteins.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: June 26, 2018
    Assignees: The Regents Of The University Of California, Amydis, Inc.
    Inventors: Jerry Yang, Emmanuel A. Theodorakis, Stella Sarraf
  • IN VITRO COMPOSITIONS COMPRISING HUMAN SAMPLE AND AMYLOID TARGETING AGENT
    Publication number: 20170248616
    Abstract: Provided herein are compositions and methods useful for detection of amyloid related disorders in samples, such as human tissue, cell or body fluid. Use of the compositions and methods herein allows for the rapid, in vitro detection of amyloid accumulation, often before amyloid disorder symptoms are manifest or without introduction of foreign fluorophore molecules into a subject.
    Type: Application
    Filed: September 11, 2015
    Publication date: August 31, 2017
    Inventor: Stella Sarraf
  • AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME
    Publication number: 20160326126
    Abstract: Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are the methods for treating of diseases associated with an amyloid or amyloid like proteins.
    Type: Application
    Filed: March 19, 2015
    Publication date: November 10, 2016
    Inventors: Jerry Yang, Emmanuel A. Theodorakis, Stella Sarraf