Abstract: The present disclosure relates, inter alia, to complexes of the Na+ leak channel non-selective protein (NALCN) with FAM155A (also called FAM155; Family with sequence similarity 155 member A), UNC79 (uncoordinated 79), and UNC80 (uncoordinated 80), methods of screening for molecules that modulate the activity of the complex, and identified modulators thereof.

Abstract: Systems and methods are disclosed for digital design tools. One example method comprises obtaining an electronic model of a structure, the electronic model including a objects, and the objects representing physical objects to be constructed. Dependencies between the objects are determined, with the determined dependencies indicating that a first object is to be constructed prior to a second object. Construction orderings are generated based on the determined dependencies, with each construction ordering indicating a unique order in which the objects are to be constructed. A user interface is presented via a user device describing the construction orderings, with a system being configured to trigger updates to the electronic model in response to received material changes associated with the electronic model.

Abstract: A computing device having an interface surface and one or more attachment features oriented on the interface surface is described. A removable support device with an interface surface and one or more attachment features oriented on the interface surface is described. A support system with a computing device and a removable support device is described. A method of using a support system is described.

Abstract: A compound comprising the formula I that has DNA-quadruplex binding and stabilising activity and potential in treatment of pancreatic and other human cancers.

Abstract: Systems and methods are disclosed for digital design tools. One example method comprises obtaining an electronic model of a structure, the electronic model including a objects, and the objects representing physical objects to be constructed. Dependencies between the objects are determined, with the determined dependencies indicating that a first object is to be constructed prior to a second object. Construction orderings are generated based on the determined dependencies, with each construction ordering indicating a unique order in which the objects are to be constructed. A user interface is presented via a user device describing the construction orderings, with a system being configured to trigger updates to the electronic model in response to received material changes associated with the electronic model.

Abstract: A compliant support for a display device is described. In one or more implementations, an apparatus includes an external enclosure configured to assume a mobile computing device configuration and one or more computing components secured by and disposed within the external enclosure. The one or more computing components are configured to perform one or more operations that are specified by software. A display device is secured to the external enclosure such that the display device is viewable by a user, the display device supporting touchscreen functionality. A compliant support is disposed between the one or more computing components and the display device, the compliant support configured to reduce deflection of the display device by compression of the compliant support, the deflection caused in response to contact against a surface of the display device.

Abstract: A computing device having an interface surface and one or more attachment features oriented on the interface surface is described. A removable support device with an interface surface and one or more attachment features oriented on the interface surface is described. A support system with a computing device and a removable support device is described. A method of using a support system is described.

Abstract: A hinge for component attachment is described. In at least some implementations, a kickstand is rotatably attached to a mobile computing device. The kickstand can be rotated to various positions to provide support for different orientations of the computing device. In at least some implementations, hinges are employed to attach a kickstand to a mobile computing device. One example hinge utilizes preset hinge stops that enable the kickstand to be placed at different preset positions. Another example hinge exerts pressure on an edge of the kickstand, providing stability and vibration dampening to the kickstand.

Abstract: Implementations of a mounting wedge for a flexible material are described. According to various embodiments, a flexible material such as a fabric is laminated to a surface of a device, such as a portable computing device. At least some embodiments utilize a mounting wedge to secure an edge of the flexible material to the device, as well as for a mounting surface for a component of the device.

Abstract: A voltage-programmed display system allows measurement of effects on pixels in a panel that includes both active pixels and reference pixels coupled to a supply line and a programming line. The reference pixels are controlled so that they are not subject to substantial changes due to aging and operating conditions over time. A readout circuit is coupled to the active pixels and the reference pixels for reading at least one of current, voltage or charge from the pixels when they are supplied with known input signals. The readout circuit is subject to changes due to aging and operating conditions over time, but the readout values from the reference pixels are used to adjust the readout values from the active pixels to compensate for the unwanted effects.

Abstract: A hinge for component attachment is described. In at least some implementations, a kickstand is rotatably attached to a mobile computing device. The kickstand can be rotated to various positions to provide support for different orientations of the computing device. In at least some implementations, hinges are employed to attach a kickstand to a mobile computing device. One example hinge utilizes preset hinge stops that enable the kickstand to be placed at different preset positions. Another example hinge exerts pressure on an edge of the kickstand, providing stability and vibration dampening to the kickstand.

Abstract: Implementations of a mounting wedge for a flexible material are described. According to various embodiments, a flexible material such as a fabric is laminated to a surface of a device, such as a portable computing device. At least some embodiments utilize a mounting wedge to secure an edge of the flexible material to the device, as well as for a mounting surface for a component of the device.

Abstract: A device kickstand is described. In at least some implementations, a kickstand is rotatably attached to a mobile computing device. The kickstand can be rotated to various positions to provide support for different orientations of the computing device. In at least some implementations, hinges are employed to attach a kickstand to a mobile computing device. One example hinge utilizes preset hinge stops that enable the kickstand to be placed at different preset positions. Another example hinge exerts pressure on an edge of the kickstand, providing stability and vibration dampening to the kickstand.

Abstract: A device kickstand is described. In at least some implementations, a kickstand is rotatably attached to a mobile computing device. The kickstand can be rotated to various positions to provide support for different orientations of the computing device. In at least some implementations, hinges are employed to attach a kickstand to a mobile computing device. One example hinge utilizes preset hinge stops that enable the kickstand to be placed at different preset positions. Another example hinge exerts pressure on an edge of the kickstand, providing stability and vibration dampening to the kickstand.

Abstract: A compliant support for a display device is described. In one or more implementations, an apparatus includes an external enclosure configured to assume a mobile computing device configuration and one or more computing components secured by and disposed within the external enclosure. The one or more computing components are configured to perform one or more operations that are specified by software. A display device is secured to the external enclosure such that the display device is viewable by a user, the display device supporting touchscreen functionality. A compliant support is disposed between the one or more computing components and the display device, the compliant support configured to reduce deflection of the display device by compression of the compliant support, the deflection caused in response to contact against a surface of the display device.

Abstract: The apparatus computes classification scores based on parameters that have been determined from documents. Each score is compared with a first and second threshold. Definite classifications are assigned when the score is above the highest threshold or below the lowest threshold and the documents are processed accordingly. If the score is between the thresholds the document is singled out for further inspection, for example by a human arbitrator, to assign a class. The first and second threshold are adapted automatically based on specified a minimum accuracy level for the classification and a training set. The apparatus uses this specified accuracy in a search for a combination of threshold values that optimizes classifier yield, in terms of a maximized fraction of patterns in a training set that need not be turned over for further inspection without definite classification.

Abstract: An interactive media commenting system includes a client computing system, a server communicatively coupled to the client computing system, a media server coupled to the client computing system and an interactive media module residing on the client computing system and configured to record and playback and interactive comment coupled to a webpage provided by the server.

Abstract: A device kickstand is described. In at least some implementations, a kickstand is rotatably attached to a mobile computing device. The kickstand can be rotated to various positions to provide support for different orientations of the computing device. In at least some implementations, hinges are employed to attach a kickstand to a mobile computing device. One example hinge utilizes preset hinge stops that enable the kickstand to be placed at different preset positions. Another example hinge exerts pressure on an edge of the kickstand, providing stability and vibration dampening to the kickstand.

Abstract: A device kickstand is described. In at least some implementations, a kickstand is rotatably attached to a mobile computing device. The kickstand can be rotated to various positions to provide support for different orientations of the computing device. In at least some implementations, hinges are employed to attach a kickstand to a mobile computing device. One example hinge utilizes preset hinge stops that enable the kickstand to be placed at different preset positions. Another example hinge exerts pressure on an edge of the kickstand, providing stability and vibration dampening to the kickstand.

Abstract: A method of determining hyperparameters (HP) of a classifier (1) in a machine learning system (10) iteratively produces an estimate of a target hyperparameter vector. The method comprises the steps of selecting from the random sample the hyperparameter vector producing the best result in the present and any previous iterations, and updating the estimate of the target hyperparameter vector by using said selected hyperparameter vector. The random sample may be restricted by using the hyperparameter vector producing the best result in the present and any previous iterations.