Abstract: Described herein is a framework for predicting development of a cardiovascular condition of interest in a patient. The framework involves determining, based on prior domain knowledge relating to the cardiovascular condition of interest, a risk score as a function of patient data. The patient data may include both genetic data and non-genetic data. In one implementation, the risk score is used to categorize the patient into at least one of multiple risk categories, the multiple risk categories being associated with different strategies to prevent the onset of the cardiovascular condition. The results generated by the framework may be presented to a physician to facilitate interpretation, risk assessment and/or clinical decision support.