Patents by Inventor Stephan Bachmann

Stephan Bachmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of halogenated benzoic acid derivatives
    Patent number: 8642802
    Abstract: The present invention comprises a process for the preparation of 3-chloro-2-fluoro-5-trifluoromethyl benzoic acid of the formula or of a salt thereof 3-Chloro-2-fluoro-5-trifluoromethyl benzoic acid or salts thereof are versatile intermediates for the preparation of active pharmaceutical or agrochemical agents.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: February 4, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Stephan Bachmann, Stefan Hildbrand, James Jappy, Dinesh Maganbhai Patel, Christophe Pfleger, Robert John Ernest Tidswell, Rene Trussardi
  • PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED CYCLIC BETA-ARYL OR HETEROARYL CARBOCYCLIC ACIDS
    Publication number: 20130253201
    Abstract: The present invention relates to a process for the preparation of cis substituted cyclic ?-aryl or heteroaryl carboxylic acid derivatives in high diastereo- and enantioselectivity by enantioselective hydrogenation in accordance with the following scheme wherein X, Ar, n, and m are defined herein and corresponding salts thereof.
    Type: Application
    Filed: May 17, 2013
    Publication date: September 26, 2013
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Stephan Bachmann, Michelangelo Scalone, Patrick Schnider
  • PDE10 MODULATORS
    Publication number: 20130059833
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used in the treatment of CNS disorders such as schizophrenia, Alzheimer's disease, and Parkinson's disease.
    Type: Application
    Filed: August 30, 2012
    Publication date: March 7, 2013
    Inventors: Stephan Bachmann, Alexander Flohr, Katrin Groebke Zbinden, Matthias Koerner, Bernd Kuhn, Jens-Uwe Peters, Markus Rudolph
  • PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES
    Publication number: 20120330055
    Abstract: The present invention comprises a process for the preparation of 3-chloro-2-fluoro-5-trifluoromethyl benzoic acid of the formula or of a salt thereof 3-Chloro-2-fluoro-5-trifluoromethyl benzoic acid or salts thereof are versatile intermediates for the preparation of active pharmaceutical or agrochemical agents.
    Type: Application
    Filed: September 7, 2012
    Publication date: December 27, 2012
    Inventors: Stephan Bachmann, Stefan Hildbrand, James Jappy, Dinesh Maganbhai Patel, Christophe Pfleger, Robert John Ernest Tidswell, Rene Trussardi
  • Process for the preparation of halogenated benzoic acid derivatives
    Patent number: 8329939
    Abstract: The present invention comprises a process for the preparation of 3-chloro-2-fluoro-5-trifluoromethyl benzoic acid of the formula or of a salt thereof. 3-Chloro-2-fluoro-5-trifluoromethyl benzoic acid or salts thereof are versatile intermediates for the preparation of active pharmaceutical or agrochemical agents.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: December 11, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Stephan Bachmann, Stefan Hildbrand, James Jappy, Dinesh Maganbhai Patel, Christophe Pfleger, Robert John Ernest Tidswell, Rene Trussardi
  • PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES
    Publication number: 20120130121
    Abstract: The present invention comprises a process for the preparation of 3-chloro-2-fluoro-5-trifluoromethyl benzoic acid of the formula or of a salt thereof 3-Chloro-2-fluoro-5-trifluoromethyl benzoic acid or salts thereof are versatile intermediates for the preparation of active pharmaceutical or agrochemical agents.
    Type: Application
    Filed: February 3, 2012
    Publication date: May 24, 2012
    Inventors: Stephan Bachmann, Stefan Hildbrand, James Jappy, Dinesh Maganbhai Patel, Christophe Pfleger, Robert John Ernest Tidswell, Rene Trussardi
  • NOVEL PROCESS
    Publication number: 20110313196
    Abstract: The present invention relates to a process for the preparation of benzamide derivatives which are useful as intermediates in the preparation of pharmaceutically active compounds.
    Type: Application
    Filed: June 6, 2011
    Publication date: December 22, 2011
    Inventors: Stephan Bachmann, Fritz Bliss, Ralph Diodone, Stefan Hildbrand, Michael Kammerer, Christophe Pfleger, Reinhard Reents, Michelangelo Scalone
  • PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED CYCLIC BETA-ARYL OR HETEROARYLCARBOCYCLIC ACIDS
    Publication number: 20110105758
    Abstract: The present invention relates to a process for the preparation of cis substituted cyclic ?-aryl or heteroaryl carboxylic acid derivatives in high diastereo- and enantioselectivity by enantioselective hydrogenation in accordance with the following scheme wherein X, Ar, n, and m are defined hereinand corresponding salts thereof.
    Type: Application
    Filed: January 11, 2011
    Publication date: May 5, 2011
    Inventors: Stephan Bachmann, Michelangelo Scalone, Patrick Schnider
  • PROCESS FOR THE PREPARATION OF A GLUCOKINASE ACTIVATOR COMPOUND
    Publication number: 20110054174
    Abstract: The present invention relates to a process for the preparation of a compound of formula I, wherein R1 is C1-6-alkyl and R2 is hydrogen or halogen. (R)-2-phenyl propionic acid derivatives of formula I are key intermediates in the synthesis of 5-substituted-pyrazine or pyridine glucokinase activators of the formula Xa, which have the potential to be useful for the treatment and/or prophylaxis of type II diabetes.
    Type: Application
    Filed: August 20, 2010
    Publication date: March 3, 2011
    Inventors: Stephan Bachmann, Alec Fettes, Hans Iding, Beat Wirz, Ulrich Zutter
  • PROCESS FOR THE PREPARATION OF (R)-2-PHENYL PROPIONIC ACID DERIVATIVES
    Publication number: 20110040091
    Abstract: The present invention relates to a process for the preparation of (R)-2-phenyl propionic acid derivatives of the formula wherein R1 is C1-6-alkyl and R2 is hydrogen or halogen, or of a salt thereof.
    Type: Application
    Filed: July 26, 2010
    Publication date: February 17, 2011
    Inventors: Stephan Bachmann, Alec Fettes, Michelangelo Scalone
  • PROCESS FOR THE PREPARATION OF HALOGENATED BENZOIC ACID DERIVATIVES
    Publication number: 20090306423
    Abstract: The present invention comprises a process for the preparation of 3-chloro-2-fluoro-5-trifluoromethyl benzoic acid of the formula or of a salt thereof. 3-Chloro-2-fluoro-5-trifluoromethyl benzoic acid or salts thereof are versatile intermediates for the preparation of active pharmaceutical or agrochemical agents.
    Type: Application
    Filed: May 29, 2009
    Publication date: December 10, 2009
    Inventors: Stephan Bachmann, Stefan Hildbrand, James Jappy, Dinesh Maganbhai Patel, Christophe Pfleger, Robert John Ernest Tidswell, Rene Trussardi
  • PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES
    Publication number: 20090012311
    Abstract: A process for the preparation of indole derivatives of formula (I): which are useful as intermediates in the preparation of pharmaceutically active compounds.
    Type: Application
    Filed: June 25, 2008
    Publication date: January 8, 2009
    Inventors: Stephan Bachmann, Philippe Pflieger, Goesta Rimmler, Michelangelo Scalone
  • Catalytic Asymmetric Synthesis of Optically Active Alpha-Halo-Carbonyl Compounds
    Publication number: 20070276142
    Abstract: A process for the catalytic asymmetric synthesis of an optically active compound of the formula (1a) or (1b) wherein R is an organic group; X is halogen; R1 and R2 which may the same or different represents H, or an organic group or R1 and R2 may be bridged together forming part of a ring system; R and R2 may be bridged together forming part of a ring system; with the provisio that R and R1 are different and R2, when different from H, is attached though a carbon-carbon bond, comprising the step of reacting a compound of the formula (2) with a halogenation agent in the presence of a catalytic amount of a chiral nitrogen containing organic compound.
    Type: Application
    Filed: February 11, 2005
    Publication date: November 29, 2007
    Inventors: Nis Halland, Karl Jorgensen, Mauro Marigo, Alan Braunton, Stephan Bachmann, Doris Schluter
  • Process for the preparation of enantiomerically enriched cyclic beta-aryl or heteroaryl carbocyclic acids
    Publication number: 20070232653
    Abstract: The present invention relates to a process for the preparation of cis substituted cyclic ?-aryl or heteroaryl carboxylic acid derivatives in high diastereo- and enantioselectivity by enantioselective hydrogenation in accordance with the following scheme wherein X, Ar, n, and m are defined herein and corresponding salts thereof.
    Type: Application
    Filed: March 30, 2007
    Publication date: October 4, 2007
    Inventors: Stephan Bachmann, Michelangelo Scalone, Patrick Schnider