Abstract: The invention shows a device for producing nanoparticles, the device having a pulsed laser with a scanning device for guiding the beam of the laser over a target that is fixed in a flow-through chamber. The flow-through chamber is reversibly connected to a supply line for carrier fluid, so that the flow-through chamber is exchangeable e.g. for a further flow-through chamber having a different target and/or a different dimensioning.

Abstract: The invention provides a process for the production of nanoparticles as well as a device that is disposed for the production of the nanoparticles. The process is especially characterized in that the nanoparticles are pure, especially free from organic carbon compounds, preferably carbon-free, and are obtained continuously. The nanoparticles which are obtainable by the process of the invention are characterized in that they are present without an organic ligand in suspension and are especially preferred stable as a suspension against agglomeration, wherein the medium having the particles suspended therein is free from organic carbon compounds, especially carbon-free.

Abstract: The invention relates to a method for producing micro-nano combined active systems in which nanoparticles of a first component are bonded to microparticles of a second component, comprising the following steps: (a) producing a low-ligand colloidal suspension containing nanoparticles of the first component, (b) adding microparticles to the colloidal suspension containing the nanoparticles or adding the colloidal suspension containing the nanoparticles to a dispersion containing the microparticles and intensively mixing so that the nanoparticles adsorb onto the microparticles, (c) separating the microparticles and the nanoparticles bonded thereto from the liquid and drying the microparticles and the nanoparticles bonded thereto.

Abstract: Copolymer-modified nanoparticles produced by a process in which nanoparticles are ablated by laser radiation from a surface of a substrate in a liquid include an amphiphilic copolymer.

Abstract: The invention relates to a method and to a device for producing conjugates comprising or consisting of a metallic nanoparticulate component and an organic component. Said method enables activated or reactive nanoparticles containing metal to be produced by irradiating a metal body with a laser beam and prevents the modification and damage of organic components of said conjugates by laser irradiation. Said nanoparticulate metallic component comprises plasmon resonant metal. According to the invention, the claimed method of production enables particles having a metal centre and a metal-oxide covering to be produced, in particular when using a carrier fluid containing oxygen, e.g. alcohol or water.

Abstract: The invention provides a process for the production of nanoparticles as well as a device that is disposed for the production of the nanoparticles. The process is especially characterized in that the nanoparticles are pure, especially free from organic carbon compounds, preferably carbon-free, and are obtained continuously. The nanoparticles which are obtainable by the process of the invention are characterized in that they are present without an organic ligand in suspension and are especially preferred stable as a suspension against agglomeration, wherein the medium having the particles suspended therein is free from organic carbon compounds, especially carbon-free.

Abstract: The present invention relates to a method and to compounds useable in the method for analysis of cells for the presence of an analyte and sorting the cells on the basis of the analyte. The compounds used in the method are optically detectable because of the content of a fluorochrome and contain a binder fraction which can specifically bind an analyte, in particular an oligonucleotide.

Abstract: The invention relates to a method for producing micro-nano combined active systems in which nanoparticles of a first component are bonded to microparticles of a second component, comprising the following steps: (a) producing a low-ligand colloidal suspension containing nanoparticles of the first component, (b) adding microparticles to the colloidal suspension containing the nanoparticles or adding the colloidal suspension containing the nanoparticles to a dispersion containing the microparticles and intensively mixing so that the nanoparticles adsorb onto the microparticles, (c) separating the microparticles and the nanoparticles bonded thereto from the liquid and drying the microparticles and the nanoparticles bonded thereto.

Abstract: Copolymer-modified nanoparticles produced by a process in which nanoparticles are ablated by laser radiation from a surface of a substrate in a liquid include an amphiphilic copolymer.

Abstract: The present invention relates to a method and to compounds useable in the method for analysis of cells for the pre-sence of an analyte and sorting the cells on the basis of the analyte. The compounds used in the method are optically detectable because of the content of a fluorochrome and contain a binder fraction which can specifically bind an analyte, in particular an oligonucleotide.

Abstract: The invention relates to a method and to a device for producing conjugates comprising or consisting of a metallic nanoparticulate component and an organic component. Said method enables activated or reactive nanoparticles containing metal to be produced by irradiating a metal body with a laser beam and prevents the modification and damage of organic components of said conjugates by laser irradiation. Said nanoparticulate metallic component comprises plasmon resonant metal. According to the invention, the claimed method of production enables particles having a metal centre and a metal-oxide covering to be produced, in particular when using a carrier fluid containing oxygen, e.g. alcohol or water.

Abstract: The present invention is directed to a biologically active device with a main body made from a polymer, in which bioactive nanoparticles of one or several materials are embedded, wherein the nanoparticles of at least one material proliferatively act on a biological material contacted by the device, and wherein nanoparticles of a different material act in an anti-proliferative manner on biological material in the ambience of the device. The invention is also directed to a method of manufacturing a biologically active device with a main body made from a polymer, wherein nanoparticles of several different materials are dispersed in an injection-moldable fluid, and the fluid is shaped into the polymer main body by means of injection molding and curing, such that the nanoparticles are dispersed in the bulk of the polymer main body.

Abstract: The invention is directed to an implant (1) with a main body (2) having a surface (5,6), and with a coating (7) of nanoparticles (8) provided at least on portions of the surface (5,6) of the main body (2), wherein the main body (2) is made from a material with a metal lattice structure, and the nanoparticles (8) of the coating (7) comprise a material which also has a metal lattice structure. The implant is characterized by the lattice structure of the material of the nanoparticles (8) being compatible in such a way to the lattice structure of the material of the main body (2), that both materials are mutually connectable by a diffusion process, in particular by a diffusion joining process. The invention is also directed to a method for manufacturing such an implant, wherein the method of manufacturing allows the simultaneous coating of a plurality of implants (1) under “mild” process conditions.