Abstract: The invention relates to an apparatus for determining an indicator that is representative of a fluid responsiveness parameter. The indicator is determined based on a fitting of a functional prototype to data values (s0) determined from pulse signals measured over subsequent respiratory cycles. The fitting process is accelerated by a) reducing the number of data values before fitting, b) determining an initial fit parameter value for the functional prototype based on characteristics of the data values and/or a fit parameter value known from a previous fitting, and/or c) carrying out the fitting in several stages, wherein the number of data values used is increased from stage to stage and a fit parameter value determined in a previous stage is used as initial fit parameter value in a current stage. This allows for a faster determination of the fluid responsiveness parameter.

Abstract: A filter element analysis system for analyzing a filter element within a vehicle, the system including various filter sensors so as to provide information regarding various filter element parameters, a locator which configured provide vehicle position information such that conditions regarding the vehicle environment can be tracked and correlated to the location, as well as a means for transmitting information to a remote server for analysis and tracking of the filter element information with regard to environmental conditions such that a filter element status, remaining filter life, or particle load and replacement timeline can be calculated and updated so as to provide more accurate predictive models of the filter element conditions. As well as provide alerts regarding the need and scheduling of replacement or cleaning of a particular filter element.

Abstract: A sensor module as well as a method for manufacturing a sensor module for determining a property of a fluid, in particular for measuring air quality, comprises a printed circuit board, at least one sensor on the printed circuit board for measuring a parameter of the surrounding air and a housing for the printed circuit board. A part of the printed circuit board protrudes from an opening in the housing (10), wherein the at least one sensor (21, 22) is located on a front side of the protruding part of the printed circuit board. In addition, at least the front side of the protruding part of the printed circuit board, with the exception of a recess for the at least one sensor, is encapsulated with a filling compound. The sensor module can be used in an interior or an air duct of motor vehicles or buildings. In one embodiment, the sensor module measures temperature, relative humidity and gas concentration in a fluid, especially in the surrounding air.

Abstract: A sealing arrangement for a centrifugal pump is provided. The sealing arrangement permits a sealing gap between a rotating element such as a pump impeller and a non-rotating element such as a pump casing to be minimized, while protecting against element wear from gap reduction and element contact, particularly during transient operation such as pump start up. At least one of the rotating element and the non-rotating element is provided with a plurality of movably mounted bodies configured to rotate and maintain separate the rotating and non-rotating elements when the sealing gap is reduced. The elements and the bodies may be formed in an additive manufacturing process.

Abstract: A filter element analysis system for analyzing a filter element within a vehicle, the system including various filter sensors so as to provide information regarding various filter element parameters, a locator which configured provide vehicle position information such that conditions regarding the vehicle environment can be tracked and correlated to the location, as well as a means for transmitting information to a remote server for analysis and tracking of the filter element information with regard to environmental conditions such that a filter element status, remaining filter life, or particle load and replacement timeline can be calculated and updated so as to provide more accurate predictive models of the filter element conditions. As well as provide alerts regarding the need and scheduling of replacement or cleaning of a particular filter element.

Abstract: A filter element analysis system for analyzing a filter element within a vehicle, the system including various filter sensors so as to provide information regarding various filter element parameters, a locator which configured provide vehicle position information such that conditions regarding the vehicle environment can be tracked and correlated to the location, as well as a means for transmitting information to a remote server for analysis and tracking of the filter element information with regard to environmental conditions such that a filter element status, remaining filter life, or particle load and replacement timeline can be calculated and updated so as to provide more accurate predictive models of the filter element conditions. As well as provide alerts regarding the need and scheduling of replacement or cleaning of a particular filter element.

Abstract: A photoacoustic gas sensor device for deter-mining a value indicative of a presence or a concentration of a component in a gas comprises a substrate and a measurement cell body, the substrate and the measurement cell body defining a measurement cell enclosing a measurement volume. A reflective shield divides the measurement volume into a first volume and a second volume. An opening in the measurement cell is provided for a gas to enter the measurement volume. In the first volume and on a front side of the substrate are arranged: An electromagnetic radiation source for emitting electromagnetic radiation through an aperture in the reflective shield into the second volume; and a pressure transducer communicatively coupled to the second volume for measuring a sound wave generated by the component in response to an absorption of electromagnetic radiation by the component. At least a portion of a surface of the reflective shield facing the second volume is made of a material reflecting electromagnetic radiation.

Abstract: Combination therapy regimens including liposomal irinotecan, oxaliplatin and 5-fluorouracil are useful in the treatment of gastric cancer, including treatment of patients diagnosed with previously untreated gastric cancer. The combination therapy can include the administration of liposomal irinotecan, oxaliplatin, leucovorin and 5-fluorouracil once every two weeks.

Abstract: A method for producing components from a duplex steel, and a component formed by the method, are provided. A powder-type duplex steel starting material including an austenitic phase and a ferritic phase is laser melted in successive layers to form a component. The melted and re-solidified component is then subjected to heat treatment to obtain solution annealing of the austenitic phase at a temperature range of between 850° C. and 1,100° C. for a predetermined dwell time, after which the component is cooled and the component has a grain size and grain size number G of at least 9 according to ASTM. The grain size and the grain size number G of the austenitic phase are influenced by the selection of the respective maximum temperature and/or the dwell time of the maximum temperature.

Abstract: An electronic component comprises a carrier (3), a sensor device (2) mounted on the carrier (3), which sensor device (2) comprises a sensor chip (21), and an electrostatic discharge protection element (1) for protecting the sensor chip (21) from an electrostatic discharge, which protection element (1) is mounted on the carrier (3).

Abstract: A sensor package comprises a sensor chip (3) with a sensitive element (31) exposed to an environment of the sensor package, and contact pads (2) for electrically contacting the sensor package. Electrical connections (5) are applied between the sensor chip (3) and the contact pads (2). A molding compound (1) at least partially encloses the sensor chip (3) and the contact pads (2). A unit (3, 73) consisting of the sensor chip (3) and optionally of a die pad (73) supporting the sensor chip (3) is arranged such that a top surface (ts) of the unit (3, 73) does not protrude from a level defined by a top surface (ts) of the contact pads (2), and a bottom surface (bs) of the unit (3,73) does not protrude from a level defined by a bottom surface (bs) of the contact pads (2).

Abstract: A sensor module as well as a method for manufacturing a sensor module for determining a property of a fluid, in particular for measuring air quality, comprises a printed circuit board, at least one sensor on the printed circuit board for measuring a parameter of the surrounding air and a housing for the printed circuit board. A part of the printed circuit board protrudes from an opening in the housing (10), wherein the at least one sensor (21, 22) is located on a front side of the protruding part of the printed circuit board. In addition, at least the front side of the protruding part of the printed circuit board, with the exception of a recess for the at least one sensor, is encapsulated with a filling compound. The sensor module can be used in an interior or an air duct of motor vehicles or buildings. In one embodiment, the sensor module measures temperature, relative humidity and gas concentration in a fluid, especially in the surrounding air.

Abstract: A filter element analysis system for analyzing a filter element within a vehicle, the system including various filter sensors so as to provide information regarding various filter element parameters, a locator which configured provide vehicle position information such that conditions regarding the vehicle environment can be tracked and correlated to the location, as well as a means for transmitting information to a remote server for analysis and tracking of the filter element information with regard to environmental conditions such that a filter element status, remaining filter life, or particle load and replacement timeline can be calculated and updated so as to provide more accurate predictive models of the filter element conditions. As well as provide alerts regarding the need and scheduling of replacement or cleaning of a particular filter element.

Abstract: A sensor package comprises a sensor chip (3) with a sensitive element (31) exposed to an environment of the sensor package, and contact pads (2) for electrically contacting the sensor package. Electrical connections (5) are applied between the sensor chip (3) and the contact pads (2). A molding compound (1) at least partially encloses the sensor chip (3) and the contact pads (2). A unit (3,73) consisting of the sensor chip (3) and optionally of a die pad (73) supporting the sensor chip (3) is arranged such that a top surface (ts) of the unit (3,73) does not protrude from a level defined by a top surface (ts) of the contact pads (2), and a bottom surface (bs) of the unit (3,73) does not protrude from a level defined by a bottom surface (bs) of the contact pads (2).

Abstract: Combination therapy regimens including liposomal irinotecan, oxaliplatin and 5-fluorouracil are useful in the treatment of gastric cancer, including treatment of patients diagnosed with previously untreated gastric cancer. The combination therapy can include the administration of liposomal irinotecan, oxaliplatin, leucovorin and 5-fluorouracil once every two weeks.

Abstract: A sealing arrangement for a centrifugal pump is provided. The sealing arrangement permits a sealing gap between a rotating element such as a pump impeller and a non-rotating element such as a pump casing to be minimized, while protecting against element wear from gap reduction and element contact, particularly during transient operation such as pump start up. At least one of the rotating element and the non-rotating element is provided with a plurality of movably mounted bodies configured to rotate and maintain separate the rotating and non-rotating elements when the sealing gap is reduced. The elements and the bodies may be formed in an additive manufacturing process.

Abstract: A sensor device comprises a sensitive element (1) and a support (2) for the sensitive element, the support having a surface (3) with an access opening (4) to the sensitive element (1). A layer of adhesive material (5) covers at least parts of the surface (3). A venting medium (6) extends over the entire surface (3) of the support (2) and the access opening (4) and is attached to the support (2) by the layer of adhesive material (5).

Abstract: A method for producing components from a duplex steel, and a component formed by the method, are provided. A powder-type duplex steel starting material including an austenitic phase and a ferritic phase is laser melted in successive layers to form a component. The melted and re-solidified component is then subjected to heat treatment to obtain solution annealing of the austenitic phase at a temperature range of between 850° C. and 1,100° C. for a predetermined dwell time, after which the component is cooled and the component has a grain size and grain size number G of at least 9 according to ASTM. The grain size and the grain size number G of the austenitic phase are influenced by the selection of the respective maximum temperature and/or the dwell time of the maximum temperature.

Abstract: An electronic component comprises a carrier (3), a sensor device (2) mounted on the carrier (3), which sensor device (2) comprises a sensor chip (21), and an electrostatic discharge protection element (1) for protecting the sensor chip (21) from an electrostatic discharge, which protection element (1) is mounted on the carrier (3).

Abstract: A pressure sensor comprises a first substrate containing a processing circuit integrated thereon and a cap attached to the first substrate. The cap includes a container, a holder, and one or more suspension elements for suspending the container from the holder. The container includes a cavity and a deformable membrane separating the cavity and a port open to an outside of the pressure sensor. The container is suspended from the holder such that the deformable membrane faces the first substrate and such that a gap is provided between the deformable membrane and the first substrate which gap contributes to the port. Sensing means are provided for converting a response of the deformable membrane to pressure at the port into a signal capable of being processed by the processing circuit.