Patents by Inventor Stephan Burkhardt

Stephan Burkhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9403987
    Abstract: Disclosed is a composition comprising a charged particle of volume 5 nm3 to 50 million nm3 preferably having an inorganic core of SiO2, AI2O3, and/or TiO2, or a core essentially consisting of an organic pigment and/or pigment derivative, and a counter ion which is separable from the particle and is not covalently linked to the particle, said counter ion comprising a silicon atom which is directly bound to a carbon atom. Preferably, said charged particle comprises a dye attached to said inorganic core and said counter ion comprises a (poly)siloxane moiety linked via suitable bridge members to a quaternary, positively charged, nitrogen or phosphorus atom, or to a moiety carrying an anionic functional group. Said composition may be used e.g. in the form of a homogenous dispersion in an electrophoretic display.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: August 2, 2016
    Assignee: BASF SE
    Inventors: Pascal Hayoz, Bernd Lamatsch, Achim Lamatsch, Margherita Fontana, Stephan Burkhardt, Laurent Michau, Urs Lehmann, Philippe Bugnon
  • Publication number: 20120229884
    Abstract: Disclosed is a composition comprising a charged particle of volume 5 nm3 to 50 million nm3 preferably having an inorganic core of SiO2, AI2O3, and/or TiO2, or a core essentially consisting of an organic pigment and/or pigment derivative, and a counter ion which is separable from the particle and is not covalently linked to the particle, said counter ion comprising a silicon atom which is directly bound to a carbon atom. Preferably, said charged particle comprises a dye attached to said inorganic core and said counter ion comprises a (poly)siloxane moiety linked via suitable bridge members to a quaternary, positively charged, nitrogen or phosphorus atom, or to a moiety carrying an anionic functional group. Said composition may be used e.g. in the form of a homogenous dispersion in an electrophoretic display.
    Type: Application
    Filed: June 11, 2010
    Publication date: September 13, 2012
    Applicant: BASF SE
    Inventors: Pascal Hayoz, Bernd Lamatsch, Achim Lamatsch (Sole Heir), Margherita Fontana, Stephan Burkhardt, Laurent Michau, Urs Lehmann, Philippe Bugnon
  • Patent number: 8026383
    Abstract: The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH3)OCH3, Ra is a hydroxy-protecting group and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: September 27, 2011
    Assignee: BASF SE
    Inventors: Reinhold Öhrlein, Gabriele Baisch, Nicole End, Stephan Burkhardt, Martin Studer
  • Publication number: 20110046411
    Abstract: The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH3)OCH3, Ra is a hydroxy-protecting group and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.
    Type: Application
    Filed: November 4, 2010
    Publication date: February 24, 2011
    Inventors: REINHOLD ÖHRLEIN, Gabriele Baisch, Nicole End, Stephan Burkhardt, Martin Studer
  • Patent number: 7855302
    Abstract: The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH3)OCH3, Ra is a hydroxy-protecting group and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: December 21, 2010
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: Reinhold Öhrlein, Gabriele Baisch, Nicole End, Stephan Burkhardt, Martin Studer
  • Patent number: 7692034
    Abstract: The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: April 6, 2010
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Reinhold Öhrlein, Gabriele Baisch, Hans Jürg Kirner, Frank Bienewald, Stephan Burkhardt, Martin Studer
  • Patent number: 7687657
    Abstract: The invention relates to a process for the preparation of (bis)acylphosphanes of formula I, wherein n and m are each independently of the other 1 or 2; R1 if n=1, is e.g. unsubstituted or substituted C1-C18alkyl or C2-C18alkenyl, or phenyl, R1 if n=2, is e.g. a divalent radical of the monovalent radical defined above; R2 is e.g. C1-C18alkyl, C3-C12cycloalkyl, C2-C18alkenyl, mesityl, phenyl, naphthyl; R3 is one of the radicals defined under R1; the process comprises the steps a) contacting e.g.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: March 30, 2010
    Assignee: Ciba Speciality Chemicals Corporation
    Inventors: Peter Murer, Jean-Pierre Wolf, Stephan Burkhardt, Hansjörg Grützmacher, Daniel Stein, Kurt Dietliker
  • Patent number: 7504532
    Abstract: Synthesis methods for the preparation of intermediates which are suitable for the preparation of statin derivatives, and especially to synthesis methods for the intermediate of formula (VI) wherein Ra? and Rc? are each independently of the other hydrogen or hydroxy-protecting group, or together are a bridging hydroxy-protecting group; and Rb is a carboxy-protecting group.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: March 17, 2009
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Reinhold Öhrlein, Gabriele Baisch, Hans Jörg Kirner, Stephan Burkhardt, Martin Studer, Frank Bienewald
  • Publication number: 20080312466
    Abstract: The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH3)OCH3, Ra is a hydroxy-protecting group and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.
    Type: Application
    Filed: July 24, 2008
    Publication date: December 18, 2008
    Inventors: Reinhold Ohrlein, Gabriele Baisch, Nicole End, Stephan Burkhardt, Martin Studer
  • Patent number: 7439401
    Abstract: The present invention relates to a new, selective process for the preparation of mono- and bisacylphosphanes of formula (I) n and m are each independently of the other 1 or 2; R1, if n=1, is e.g. phenyl R1, if n=2, is e.g. C1-C18alkylene or phenylene; R2 is e. g. C1-C18alkyl, phenyl or substituted phenyl; R3 is e. g. C1-C18alkyl, by (1) reacting a phosphorous halide of formula IIa or a phosphorous halide oxide of formula (IIb) or a phosphorous halide sulfide of formula (IIc) with an alkali metal in a solvent in the presence of a proton source; (2) subsequent reaction with m acid halides of formula (III) An oxidation step may follow to obtain mono- and bisacylphosphane oxides or mono- and bisacylphosphane sulfides.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: October 21, 2008
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Reinhard H. Sommerlade, Souâd Boulmaâz, Jean-Pierre Wolf, Jens Geier, Hansjörg Grützmacher, Markus Scherer, Hartmut Schönberg, Daniel Stein, Peter Murer, Stephan Burkhardt
  • Patent number: 7420078
    Abstract: The invention relates to synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or N(CH3)OCH3, Ra is a hydroxy-protecting group, and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further intermediates and methods for their preparation by Friedel-Crafts acylation.
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: September 2, 2008
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: Reinhold Öhrlein, Gabriele Baisch, Nicole End, Stephan Burkhardt, Martin Studer
  • Publication number: 20080125601
    Abstract: Synthesis methods for the preparation of intermediates which are suitable for the preparation of statin derivatives, and especially to synthesis methods for the intermediate of formula (VI) wherein Ra? and Rc? are each independently of the other hydrogen or hydroxy-protecting group, or together are a bridging hydroxy-protecting group; and Rb is a carboxy-protecting group.
    Type: Application
    Filed: November 16, 2007
    Publication date: May 29, 2008
    Inventors: Reinhold Ohrlein, Gabriele Baisch, Hans Jorg Kirner, Stephan Burkhardt, Martin Studer, Frank Bienewald
  • Patent number: 7317123
    Abstract: The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra? and Rc? are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XVI wherein Ra? and Rc? are each independently of the other hydrogen or a hydroxy-protecting group, R* and R** are each independently of the other hydrogen or an amide-protecting group, and Rb is a carboxy-protecting group; which methods proceed to further new intermediates and methods for their preparation
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: January 8, 2008
    Assignee: Teva Pharmaceutical Industries, Ltd
    Inventors: Reinhold Öhrlein, Gabriele Baisch, Hans Jörg Kirner, Stephan Burkhardt, Martin Studer, Frank Bienewald
  • Publication number: 20080004464
    Abstract: The invention relates to a process for the preparation of (bis)acylphosphanes of formula I, wherein n and m are each independently of the other 1 or 2; R1 if n=1, is e.g. unsubstituted or substituted C1-C18alkyl or C2-C18alkenyl, or phenyl, R1 if n=2, is e.g. a divalent radical of the monovalent radical defined above; R2 is e.g. C1-C18alkyl, C3-C12cycloalkyl, C2-C18alkenyl, mesityl, phenyl, naphthyl; R3 is one of the radicals defined under R1; the process comprises the steps a) contacting e.g.
    Type: Application
    Filed: November 14, 2005
    Publication date: January 3, 2008
    Inventors: Peter Murer, Jean-Pierre Wolf, Stephan Burkhardt, Hansjorg Grutzmacher, Daniel Stein, Kurt Dietliker
  • Publication number: 20070142662
    Abstract: The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group.
    Type: Application
    Filed: January 24, 2007
    Publication date: June 21, 2007
    Inventors: Reinhold Ohrlein, Gabriele Baisch, Hans Jurg Kirner, Frank Bienewald, Stephan Burkhardt, Martin Studer
  • Patent number: 7199261
    Abstract: The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: April 3, 2007
    Assignee: Teva Pharmaceutical Industries Ltd
    Inventors: Reinhold Öhrlein, Gabriele Baisch, Hans Jürg Kirner, Frank Bienewald, Stephan Burkhardt, Martin Studer
  • Publication number: 20060247436
    Abstract: The present invention relates to a new, selective process for the preparation of mono- and bisacylphosphanes of formula (I) n and m are each independently of the other 1 or 2; R1, if n=1, is e.g. phenyl R1, if n=2, is e.g. C1-C18alkylene or phenylene; R2 is e.g. C1-C18alkyl, phenyl or substituted phenyl; R3 is e.g. C1-C18alkyl, by (I) reacting a phosphorous halide of formula IIa or a phosphorous halide oxide of formula (IIb) or a phosphorous halide sulfide of formula (IIc) with an alkali metal in a solvent in the presence of a proton source; (2) subsequent reaction with m acid halides of formula (III) An oxidation step may follow to obtain mono- and bisacylphosphane oxides or mono-and bisacylphosphane sulfides.
    Type: Application
    Filed: July 9, 2004
    Publication date: November 2, 2006
    Inventors: Reinhard Sommerlade, Souad Boulmaaz, Jean-Pierre Wolf, Jens Geier, Hansjorg Grutzmacher, Markus Scherer, Hartmut Schonberg, Daniel Stein, Peter Murer, Stephan Burkhardt
  • Patent number: 7019161
    Abstract: The present invention relates to novel processes for the preparation of optically active 3-aminocarboxylic acids and their esters, in particular processes for the preparation of optically active compounds of the formula IA or IB as free bases or as acid addition salts thereof, in which the radicals are as defined in the description; in particular using the catalytic hydrogenation of olefinic precursors in the presence of platinum on alumina as a catalyst and the removal of chiral auxiliary groups from salt precursors; and novel process sections in the route for their synthesis, and processes for the preparation of biologically, in particular pharmacologically, active compounds, which comprise the novel processes.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: March 28, 2006
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Kai-Uwe Schöning, Martin Studer, Hans Jürg Kirner, Stephan Burkhardt
  • Publication number: 20050033086
    Abstract: The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group.
    Type: Application
    Filed: July 2, 2002
    Publication date: February 10, 2005
    Inventors: Reinhold Ohrlein, Gabriele Baisch, Hans Kirner, Frank Bienewald, Stephan Burkhardt, Martin Studer
  • Publication number: 20040242916
    Abstract: The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra′ and Rc′ are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XVI wherein Ra′ and Rc′ are each independently of the other hydrogen or a hydroxy-protecting group, R* and R** are each independently of the other hydrogen or an amide-protecting group, and Rb is a carboxy-protecting group; which methods proceed to further new intermediates and methods for their preparation.
    Type: Application
    Filed: July 6, 2004
    Publication date: December 2, 2004
    Inventors: Reinhold Ohrlein, Gabriele Baisch, Hans Jorg Kirner, Stephan Burkhardt, Martin Studer, Frank Bienewald