Patents by Inventor Stephan Cripps

Stephan Cripps has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel compounds of amino sulfonyl derivatives
    Publication number: 20070027118
    Abstract: The present invention relates to compounds with formula (I) or a pharmaceutically acceptable salt thereof: wherein; T is a (4 to 10)-membered heterocyclyl and wherein R1, R2 and R3 are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of the 11-?-hsd-1 enzyme.
    Type: Application
    Filed: April 6, 2006
    Publication date: February 1, 2007
    Inventors: Hengmiao Cheng, Stephan Cripps, Klaus Dress, Buwen Huang, Sajiv Nair, Yong Wang
  • Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
    Patent number: 7045528
    Abstract: The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: May 16, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Michael Collins, Stephan Cripps, Judith Deal, Robert Steven Kania, Jihong Lou, Mingying He, Cynthia Louise Palmer, William Henry Romines, III, Ru Zhou
  • Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
    Publication number: 20060079548
    Abstract: The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Application
    Filed: October 21, 2005
    Publication date: April 13, 2006
    Inventors: Michael Collins, Stephan Cripps, Judith Deal, Robert Kania, Jihong Lou, Mingying He, Cynthia Palmer, William Romines, Ru Zhou
  • Novel compounds of proline and morpholine derivatives
    Publication number: 20050261290
    Abstract: The present invention relates to compounds with the formulas (I), (II), and (III), or a pharmaceutically acceptable salt thereof: wherein T is a (4 to 10)-membered heterocyclyl selected from the group consisting of and wherein R1, R2 and R3 are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formulas (I), (II), and (III) and methods of treating a condition that is mediated by the modulation of the 11-?-hsd-1 enzyme, the method comprising administering to a mammal an effective amount of a compound of formulas (I), (II), and (III).
    Type: Application
    Filed: May 4, 2005
    Publication date: November 24, 2005
    Inventors: Hengmiao Cheng, Stephan Cripps, Klaus Dress, Jacqui Hoffman, Buwen Huang, Stanley Kupchinsky, Phuong Le, Sajiv Nair, Timothy Parrott, Christopher Smith, Yong Wang, Yi Yang
  • Amino heterocyclyl inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
    Publication number: 20050148631
    Abstract: The present invention relates to compounds with the formula (I), or a pharmaceutically acceptable salt thereof: The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) or formula (II) and methods of treating a condition that is mediated by the modulation of 11-?-hsd-1, the method comprising administering to a mammal an effective amount of a compound of formula (I) or formula (II).
    Type: Application
    Filed: December 17, 2004
    Publication date: July 7, 2005
    Inventors: Hengmiao Cheng, Stephan Cripps, Martin Edwards, Theodore Johnson, Sajiv Nair, Michael Siu, Christopher Smith, Wendy Taylor, Yong Wang
  • Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
    Publication number: 20050124662
    Abstract: Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
    Type: Application
    Filed: November 18, 2004
    Publication date: June 9, 2005
    Inventors: Robert Kania, Steven Bender, Allen Borchardt, Stephan Cripps, Cynthia Louise Palmer, Anna Maria Tempczyk-Russell, Michael Varney, Michael Raymond Collins
  • Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
    Patent number: 6869962
    Abstract: The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: March 22, 2005
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Michael Collins, Stephan Cripps, Judith Deal, Robert Steven Kania, Jihong Lou, Mingying He, Cynthia Louise Palmer, William Henry Romines, III, Ru Zhou
  • Indolyl-urea derivatives of thienopyridines useful as antiangiogenic agents, and methods for their use
    Patent number: 6833456
    Abstract: The invention relates to compounds represented by the formula I and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein X, R1 and R11 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: December 21, 2004
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: William Henry Romines, III, Robert Steven Kania, Jihong Lou, Stephan Cripps, Ru Zhou, Mingying He
  • Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
    Publication number: 20040186126
    Abstract: The invention relates to compounds represented by the formula I 1
    Type: Application
    Filed: March 9, 2004
    Publication date: September 23, 2004
    Applicant: Agouron Pharmaceuticals, Inc.
    Inventors: Michael Collins, Stephan Cripps, Judith Deal, Robert Steven Kania, Jihong Lou, Mingying He, Cynthia Louise Palmer, William Henry Romines, Ru Zhou
  • Indolyl-urea derivatives of thienopyridines useful as antiangiogenic agents, and methods for their use
    Publication number: 20040019065
    Abstract: The invention relates to compounds represented by the formula I 1
    Type: Application
    Filed: February 21, 2003
    Publication date: January 29, 2004
    Inventors: William Henry Romines, Robert Steven Kania, Jihong Lou, Stephan Cripps, Ru Zhou, Mingying He
  • Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
    Publication number: 20040009965
    Abstract: The invention relates to compounds represented by the formula I 1
    Type: Application
    Filed: June 11, 2003
    Publication date: January 15, 2004
    Applicant: Agouron Pharmaceuticals, Inc.
    Inventors: Michael Collins, Stephan Cripps, Judith Deal, Robert Steven Kania, Jihong Lou, Mingying He, Cynthia Louise Palmer, William Henry Romines, Ru Zhou