Abstract: The present invention provides for a method of measuring layer thickness in an object comprising 1) transmitting at least a first and a second ultrasound pulse from at least a first and second position, 2) measuring at least one reflective distance from the first pulse and at least one reflective distance from the second pulse, wherein the reflective distance is from the object's external surface (or probe) to a reflective interface of at least one layer, 3) selecting the reflective distance having the shortest reflective distance to indicate the distance between the external surface (or probe surface) and the reflective interface of at least one layer, wherein the selecting of the shortest reflective distance reduces ultrasound transmission parallax of the first and second pulses relative to a plane in the object. Other ultrasound methods and devices are disclosed for measuring layer thickness in patients or subjects in need thereof, particularly subjects in need of fat or muscle measurement.