Patents by Inventor Stephan Hüttel

Stephan Hüttel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chlorotonil derivatives
    Patent number: 11365201
    Abstract: The present invention relates to novel chlorotonil derivatives of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections and malaria.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: June 21, 2022
    Assignee: Helmholtz-Zentrum Für Infektionsforschung GmbH
    Inventors: Antione Abou Fayad, Jennifer Herrmann, Katrin Jungmann-Sahner, Rolf Müller, Kathrin Mohr, Steffen Bernecker, Stephan Hüttel, Rolf Jansen, Emilia Oueis, Anastasia Andreas
  • Targeted cytotoxic ratjadone derivatives and conjugates thereof
    Patent number: 11236059
    Abstract: The present invention is directed to novel natural product-derived ratjadone-based compounds useful as payloads (or toxins) in drug-conjugates constructs with cell target binding moieties (CTBM) and payload-linker compounds useful in connection with drug conjugates. The present invention further relates to new ratjadone compositions including the aforementioned payloads, payload-linkers and drug conjugates, and methods for using these payloads, payload-linkers and drug conjugates, to treat pathological conditions including cancer, inflammatory and infectious diseases.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: February 1, 2022
    Assignee: HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH
    Inventors: Philipp Klahn, Mark Broenstrup, Verena Fetz, Wera Collisi, Katrin I Mohr, Stephan Huettel, Werner Tegge
  • Crystobactamides
    Patent number: 11225503
    Abstract: The present invention provides cystobactamides of formula (I): R1—Ar1-L1-Ar2-L2-Ar3-L3-Ar4-L4-Ar5—R2 and the use thereof for the treatment or prophylaxis of bacterial infections.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: January 18, 2022
    Assignee: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
    Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Huettel
  • CHLOROTONIL DERIVATIVES
    Publication number: 20210371426
    Abstract: The present invention relates to novel chlorotonil derivatives of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections and malaria.
    Type: Application
    Filed: November 7, 2018
    Publication date: December 2, 2021
    Inventors: Antione Abou Fayad, Jennifer Herrmann, Katrin Jungmann-Sahner, Rolf Müller, Kathrin Mohr, Steffen Bernecker, Stephan Hüttel, Rolf Jansen, Emilia Oueis, Anastasia Andreas
  • CYSTOBACTAMIDES
    Publication number: 20200331964
    Abstract: The present invention provides cystobactamides of formula (I): R1—Ar1-L1-Ar2-L2-Ar3-L3-Ar4-L4-Ar5—R2 and the use thereof for the treatment or prophylaxis of bacterial infections.
    Type: Application
    Filed: June 10, 2020
    Publication date: October 22, 2020
    Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Huettel
  • Cystobactamides
    Patent number: 10793600
    Abstract: The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: October 6, 2020
    Assignee: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
    Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Hüttel
  • TARGETED CYTOTOXIC RATJADONE DERIVATIVES AND CONJUGATES THEREOF
    Publication number: 20200239426
    Abstract: The present invention is directed to novel natural product-derived ratjadone-based compounds useful as payloads (or toxins) in drug-conjugates constructs with cell target binding moieties (CTBM) and payload-linker compounds useful in connection with drug conjugates. The present invention further relates to new ratjadone compositions including the aforementioned payloads, payload-linkers and drug conjugates, and methods for using these payloads, payload-linkers and drug conjugates, to treat pathological conditions including cancer, inflammatory and infectious diseases.
    Type: Application
    Filed: August 8, 2018
    Publication date: July 30, 2020
    Inventors: Philipp KLAHN, Mark BROENSTRUP, Verena FETZ, Wera COLLISI, Katrin I MOHR, Stephan HUETTEL, Werner TEGGE
  • Cystobactamides
    Patent number: 10519099
    Abstract: The present invention provides a method for the treatment or prophylaxis of bacterial infections by administering to a subject in need thereof an effective amount of a compound of formula.
    Type: Grant
    Filed: November 26, 2015
    Date of Patent: December 31, 2019
    Assignee: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
    Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Hüttel
  • CYSTOBACTAMIDES
    Publication number: 20190185514
    Abstract: The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections: R1—Ar1-L1-Ar2-L2-Ar3-L3-Ar4-L4-Ar5—R2??(I):
    Type: Application
    Filed: July 23, 2018
    Publication date: June 20, 2019
    Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Hüttel
  • NOVEL CYSTOBACTAMIDES
    Publication number: 20170327458
    Abstract: The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections.
    Type: Application
    Filed: November 26, 2015
    Publication date: November 16, 2017
    Applicant: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
    Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Hüttel
  • NOVEL CHONDRAMIDE DERIVATIVES
    Publication number: 20150291658
    Abstract: The present invention provides novel chondramide derivatives of formula (I) which can be used for the treatment of cancer.
    Type: Application
    Filed: November 22, 2013
    Publication date: October 15, 2015
    Inventors: Rolf Müller, Stephan Hüttel, Jennifer Herrmann, Uli Kazmaier, Dominic Becker