Abstract: The present invention relates to a nutritionally optimized synthetic or recombinant collagen peptide comprising at least one amino acid sequence motif (glycine-X-Y)n, and the collagen peptide according to the invention for use in a method for therapeutic treatment of the human or animal body and products containing the collagen peptide according to the invention.

Abstract: A transmission device (5) for an electrically drivable vehicle axle (1) includes a transmission input shaft (7), a transmission output shaft (10) connected thereto via gear-wheel pairs (8, 9), and a parking lock device (15). The parking lock device (15) is arranged in a transmission housing (11) and includes an electric actuator (16) for actuating a locking pawl (18) engageable with a parking interlock gear (19) operatively connected to the transmission output shaft (10). The locking pawl and the parking interlock gear (19) are arranged in an interior space (14) of the transmission housing (11) that is acted upon by oil, and the electric actuator (16) is arranged in an oil-free interior space (13) of the transmission housing (11). The output shaft (21) of the electric actuator (16) extends through an intermediate wall (12) and is operatively connected to the locking pawl.

Abstract: An actuator for actuating a shift element in a transmission of a vehicle, particularly of a utility vehicle, includes a sensor device for detecting angular positions of a rotating component, for example, a shaft in an electric drive for a vehicle. The sensor device includes an annular encoder magnet fastened to a support pin supported on a front side of the rotating component so as to be fixed with respect to rotation relative to it such that the annular encoder magnet at least partially surrounds the support pin. The annular encode magnet is mounted on the support pin as a molded encoder magnet component.

Abstract: A gearbox actuator unit (14) is configured to be arranged on a gearbox (10) and includes a housing (22), a control device (24), and an actuator (28, 30). The housing (22) is configured to attach to a gearbox housing (12) and to seal the gearbox housing (12). The control device (24) is electrically connected to the actuator (28, 30) and activates the actuator (28, 30). A pinon of the actuator (28, 30) is configured to actuate a rack of a shift fork (18, 20) of the gearbox (10) and can be connected to the shift fork (18, 20) of the gearbox (10). The control device (24) and the actuator (28, 30) are arranged within the housing (22), with the pinion extending through an opening of the housing. A gearbox (10) with a housing (12) having an opening (44) receives the actuator unit (14), which closes and seals the opening (44).

Abstract: A gearbox actuator unit (12) is formed so as to be to be arranged on a gearbox (10). The unit (12) has a flange (14), an actuator (16, 18), a rack (20, 22) and a guide (24, 26). The flange (14) is formed to be connectable to a housing of the gearbox. The rack (20, 22) is received in an axially moveable manner within the guide (24, 26). The actuator (16, 18) meshes with the rack (20, 22) via a pinion (44, 46) and is formed so as to move the rack (20, 22) axially.

Abstract: An actuating apparatus has a first and a second actuating element that delimit a pressure chamber. The actuating apparatus has a rotary decoupling bearing coupled via a compensation assembly to the second actuating element for joint movement along the spatial axis. The compensation assembly comprises a first ramp element which is supported axially on the second actuating element and is preloaded relative to the second actuating element by a first preloading apparatus for rotation about the spatial axis and a second ramp element coupled to the rotary decoupling bearing. An axial overall length of the compensation group along the spatial axis changes in the case of a rotation, of the first ramp element relative to the second actuating element.

Abstract: An actuating apparatus has a first and a second actuating element that delimit a pressure chamber. The actuating apparatus has a rotary decoupling bearing coupled via a compensation assembly to the second actuating element for joint movement along the spatial axis. The compensation assembly comprises a first ramp element which is supported axially on the second actuating element and is preloaded relative to the second actuating element by a first preloading apparatus for rotation about the spatial axis and a second ramp element coupled to the rotary decoupling bearing. An axial overall length of the compensation group along the spatial axis changes in the case of a rotation, of the first ramp element relative to the second actuating element.

Abstract: An actuating device for a motor vehicle, including a housing and a multi-part working piston movable in relation to the housing. The multi-part working piston has a main piston and an adjusting piston, which pistons are formed in a manner movable axially with respect to each other to compensate for wear. A clamping device clamps the main piston and the adjusting piston in relation to each other in order to fix an operative length of the working piston. The main piston and the adjusting piston are partial pistons of the working piston. A shielding element for protecting the actuating device from dirt is arranged on the housing and a partial piston or on a first partial piston and a second partial piston or on an adjusting piston and on the clamping device.

Abstract: An actuating device for a motor vehicle, including a housing and a multi-part working piston movable in relation to the housing. The multi-part working piston has a main piston and an adjusting piston, which pistons are formed in a manner movable axially with respect to each other to compensate for wear. A clamping device clamps the main piston and the adjusting piston in relation to each other in order to fix an operative length of the working piston. The main piston and the adjusting piston are partial pistons of the working piston. A shielding element for protecting the actuating device from dirt is arranged on the housing and a partial piston or on a first partial piston and a second partial piston or on an adjusting piston and on the clamping device.

Abstract: The invention relates to a method for the diagnosis of malignant diseases comprising the steps Provision of a sample obtained from a bodily fluid or bodily excretion as well as Determination of the concentration of snRNA RNU2-1 or their fragments in the sample, as well as a kit for the performance of this diagnosis, and the use of probes specific to RNU2-1 and fragments thereof.

Abstract: The invention relates to a method for diagnosing pancreatic cancer (PaCa) or the precursor diseases and/or concomitant diseases thereof, in particular pancreatic ductal adenocarcinoma (PDAC), pancreatic intraepithelial neoplasia (PanIN), pancreatic lesions, chronic pancreatitis (CP), including endocrine pancreatic tumors. In said method, the diagnosis is performed using selected biomarkers. The invention further relates to biomarker combinations suitable for carrying out said method, particularly for in vitro diagnosis.

Abstract: Polynucleotide and polypeptide sequences encoding a novel tumor suppressor gene, DPC4, are provided. Also included is a method for detecting a cell proliferative disorder associated with DPC4. DPC4 is a marker which can be used diagnostically, prognostically and therapeutically over the course of disorders associated with DPC4.

Abstract: Polynucleotide and polypeptide sequences encoding a novel tumor suppressor gene, DPC4, are provided. Also included is a method for detecting a cell proliferative disorder associated with DPC4. DPC4 is a marker which can be used diagnostically, prognostically and therapeutically over the course of disorders associated with DPC4.

Abstract: Polynucleotide and polypeptide sequences encoding a novel tumor suppressor gene, DPC4, are provided. Also included is a method for detecting a cell proliferative disorder associated with DPC4. DPC4 is a marker which can be used diagnostically, prognostically and therapeutically over the course of disorders associated with DPC4.