Abstract: A method of identifying an effective composition of antigens for a tumor vaccine includes determination of antibodies produced by at least 10 patients after vaccination with an autologous vaccine obtained by gathering tumor material from the patients, separating the tumor cells from accompanying tissue, inactivating the tumor cells and providing them in a form suitable for administration as autologous vaccine, application of the autologous vaccine to the patients, isolation and determination of the antibodies produced by the patients' immune response that have been found to be shared by at least 80% of the patients, and identifying the antigens corresponding to the determined antibodies. A method of manufacturing a tumor vaccine is performed from the identified antigens and danger signals, and a tumor vaccine is obtained thereby.