Abstract: Systems and methods are disclosed for increasing a nuclear spin polarization of a target compound. In accordance with such systems and methods, a first non-thermal equilibrium nuclear spin polarization can be imparted to at least one source atom of a source compound, the source atom having a nuclear gyromagnetic ratio of at least 12 megahertz per tesla (MHz/T). A first solution can be obtained that includes the source compound and a target compound. The at least one source atom can be present in a source concentration of at least 0.1 molar (M) in the first solution. A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to the at least one target atom of the target compound via a nuclear Overhauser effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to the at least one target atom.

Abstract: Systems and methods are disclosed for containing parahydrogen. In some of the systems and methods, a gas cylinder is configured to contain hydrogen gas therein. The hydrogen gas may include parahydrogen gas at a first concentration of at least 45% and a pressure of at most 40 bar. The parahydrogen gas may have a decay time constant of at least 30 days. The parahydrogen gas may be for use in a PHIP, PHIP-SAH, SABRE, or PHIPNOESYS NMR or MRI experiment. In some of the systems and methods, a cryogenic chamber is configured to contain liquid hydrogen therein. The liquid hydrogen may include liquid parahydrogen at a concentration of at least 50 mole percent. The liquid hydrogen may be boiled to generate hydrogen gas containing at least 50 mole percent parahydrogen gas. The parahydrogen gas may be for use in a PHIP, PHIP-SAH, SABRE, or PHIPNOESYS NMR or MRI experiment.

Abstract: Systems and methods are disclosed for increasing a nuclear spin polarization of a target compound. In accordance with such systems and methods, a first non-thermal equilibrium nuclear spin polarization can be imparted to at least one source atom of a source compound, the source atom having a nuclear gyromagnetic ratio of at least 12 megahertz per tesla (MHz/T). A first solution can be obtained that includes the source compound and a target compound. The at least one source atom can be present in a source concentration of at least 0.1 molar (M) in the first solution. A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to the at least one target atom of the target compound via a nuclear Overhauser effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to the at least one target atom.

Abstract: Systems and methods are disclosed for increasing a nuclear spin polarization in a target compound. A parahydrogenated solution can be generated using a solvent, parahydrogen gas, and a precursor of the target compound. A polarized solution containing the hyperpolarized target compound can be generated using a polarization device and the parahydrogenated solution. The polarization device can include a polarization chamber, one or more radiofrequency (RF) coils disposed around the polarization region, a magnetic field source disposed around the polarization region, and an RF waveform generator configurable to apply a polarization transfer waveform to the one or more RF coils. The polarization chamber can include a polarization region having a volume of at least 10 milliliters (mL). The magnetic field source can be configured to provide a mean magnetic field strength of at most 200 millitesla (mT). A purified fraction can be separated from the polarized solution using a purification system.

Abstract: The present disclosure describes hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes methods for producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes precursor compounds for use in producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications.

Abstract: Systems and methods are disclosed for increasing a nuclear spin polarization in a target compound. Nuclear spin polarization can be increased by obtaining the target compound or a precursor of the target compound. The target compound or precursor can include a first proton and a second proton sharing a singlet spin order and a third proton coupled at least to one of the first proton or the second proton. A target atom can be coupled to at least the third proton. The precursor can be placed within a mean magnetic field strength below 500 mT. A magnetic resonance (MR) pulse sequence can be applied to the precursor. the MR pulse sequence configured to transfer population from the first and second protons to the target atom, thereby imparting a non-equilibrium nuclear spin polarization of at least 1%, 2%, 5%, 10%, or 20% to the target atom.

Abstract: Systems and methods are disclosed for increasing a nuclear spin polarization of a target compound. In accordance with such systems and methods, a first non-thermal equilibrium nuclear spin polarization can be imparted to at least one source atom of a source compound, the source atom having a nuclear gyromagnetic ratio of at least 12 megahertz per tesla (MHz/T). A first solution can be obtained that includes the source compound and a target compound. The at least one source atom can be present in a source concentration of at least 0.1 molar (M) in the first solution. A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to the at least one target atom of the target compound via a nuclear Overhauser effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to the at least one target atom.

Abstract: The present disclosure describes hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes methods for producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes precursor compounds for use in producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications.

Abstract: The present disclosure describes hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes methods for producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes precursor compounds for use in producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications.

Abstract: The present disclosure describes hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes methods for producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes precursor compounds for use in producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications.

Abstract: An application system for applying a flowable medium, in particular a hot melt adhesive, to a substrate, and a heating hose for supplying a flowable medium to an application device for applying the flowable medium to a substrate. In the application system, the application device and the heating hose are coupled detachably to one another via a connection piece, wherein the connection piece has a receiving section for a filter insert.

Abstract: A heated hose for passage of a free-flowing medium, for example for the passage of a hot-melt adhesive. The heated hose has an angled attachment piece, wherein the attachment piece has a first limb and, angled with respect to the first limb, a second limb, wherein the attachment piece has a through-channel which runs through the limbs to allow the free-flowing medium to pass through the attachment piece, and wherein the attachment piece has a coupling connector for producing a fluidic connection between the heated hose and an external apparatus, by coupling the external apparatus along a coupling axis of the coupling connector.

Abstract: Systems and methods are disclosed for increasing a nuclear spin polarization in a target compound. Nuclear spin polarization can be increased by obtaining the target compound or a precursor of the target compound. The target compound or precursor can include a first proton and a second proton sharing a singlet spin order and a third proton coupled at least to one of the first proton or the second proton. A target atom can be coupled to at least the third proton. The precursor can be placed within a mean magnetic field strength below 500 mT. A magnetic resonance (MR) pulse sequence can be applied to the precursor. the MR pulse sequence configured to transfer population from the first and second protons to the target atom, thereby imparting a non-equilibrium nuclear spin polarization of at least 1 %, 2%, 5%, 10%, or 20% to the target atom.

Abstract: Systems and methods are disclosed for increasing a nuclear spin polarization of a target compound. In accordance with such systems and methods, a first non-thermal equilibrium nuclear spin polarization can be imparted to at least one source atom of a source compound, the source atom having a nuclear gyromagnetic ratio of at least 12 megahertz per tesla (MHz/T). A first solution can be obtained that includes the source compound and a target compound. The at least one source atom can be present in a source concentration of at least 0.1 molar (M) in the first solution. A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to the at least one target atom of the target compound via a nuclear Overhauser effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to the at least one target atom.

Abstract: The present disclosure describes hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes methods for producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications. The present disclosure describes precursor compounds for use in producing hyperpolarized materials for use in nuclear magnetic resonance, magnetic resonance imaging, or similar applications.

Abstract: A heated hose for delivering a liquid, in particular for delivering an adhesive has a flexible hose for the passage of the liquid, an insulating layer surrounding the flexible hose, and a heating device surrounding the flexible hose. The heating device is arranged between the flexible hose and the insulating layer. The insulating layer has a strip-shaped insulating material that is wound helically around the flexible hose. The strip-shaped insulating material contains an aerogel.