Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.

Abstract: Methods of detecting a leak from a subarray of a microarray chip, kits of components that facilitate leak detection, and microarray chips configured for leak detection are disclosed herein. The methods include positioning, within the given subarray, a sample solution, which includes dissolved sample molecules (DSMs) that define a dissolved sample oligonucleotide sequence and dissolved leak detection molecules (DLDMs) that define a predetermined dissolved leak detection oligonucleotide sequence. The methods also include detecting the DLDMs within a region of the microarray chip that is external the given subarray. The kits of components include the microarray chip and DLDMs. The microarray chips includes a plurality of subarrays and a leak detection region that is at least partially external the plurality of subarrays.

Abstract: The pressing tool includes two pressing jaws which are movable towards one another from an open position into a closed position for pressing, said pressing jaws including a connecting element for connection to respective receiving elements of the pressing ring, so that the press ring is movable from an open position into a closed position by the movement of the pressing jaws for pressing the press fitting. The minimum spacing of the connecting elements in the open position is greater than the maximum spacing of the receiving elements of the press ring in the open position, and the minimum spacing of the connecting elements in the closed position corresponds to a minimum spacing of the receiving elements of the press ring in the closed position. Furthermore, the minimum spacing of the connecting elements in the open position is smaller than the maximum spacing of the receiving elements of a second press ring in the open position, so that connection to the second press ring is prevented.

Abstract: Press ring, pressing tool, adapter element for a pressing tool, adapter element for a press ring, pressing device having an electric drive and a pressing tool, system having an adapter element for pressing a press fitting by means of a press ring. Here, the press ring has at least two different pairs of receiving elements for connection to a corresponding pair of connecting elements of different pressing tools. The pressing tool has at least two different pairs of connecting elements for connection to respectively one corresponding pair of receiving elements of different press rings. The adapter elements for a pressing tool and press ring each have a pair of connecting elements for connection to a corresponding pair of connecting elements of a pressing tool and a pair of connecting elements for connection to a corresponding pair of receiving elements of a press ring.

Abstract: Methods, devices, reagents and kits designed to improve the performance of proteomic based assays are provided. Such methods have a wide utility in proteomic applications for research and development, diagnostics and therapeutics by providing for a reduction or elimination of background signal and improved specificity for protein binding reagents in a multiplex assay formats.

Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.

Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.

Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.

Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

Abstract: Embodiments provide a slide assembly device having a static tooling base which is statically and solidly affixed to a base such as a table and a moveable tooling arm that is rotatable about a hinge connected to the static tooling base, so that moveable tooling arm rotates about the hinge in a manner similar to a book cover opening and closing. The embodiments further provide an upper slide chuck that is removably attachable to the moveable tooling arm and a lower slide receiver that is removably attachable to the static tooling base. The upper slide chuck is configured to hold an experimental slide via a vacuum mechanism to engagedly hold the experimental slide to the upper slide chuck while the moveable tooling arm is rotated about the hinge from an open-book position to a closed-book position.

Abstract: Embodiments provide a slide assembly device having a static tooling base which is statically and solidly affixed to a base such as a table and a moveable tooling arm that is rotatable about a hinge connected to the static tooling base, so that moveable tooling arm rotates about the hinge in a manner similar to a book cover opening and closing. The embodiments further provide an upper slide chuck that is removably attachable to the moveable tooling arm and a lower slide receiver that is removably attachable to the static tooling base. The upper slide chuck is configured to hold an experimental slide via a vacuum mechanism to engagedly hold the experimental slide to the upper slide chuck while the moveable tooling arm is rotated about the hinge from an open-book position to a closed-book position.

Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.

Abstract: Embodiments provide a slide assembly device having a static tooling base which is statically and solidly affixed to a base such as a table and a moveable tooling arm that is rotatable about a hinge connected to the static tooling base, so that moveable tooling arm rotates about the hinge in a manner similar to a book cover opening and closing. The embodiments further provide an upper slide chuck that is removably attachable to the moveable tooling arm and a lower slide receiver that is removably attachable to the static tooling base. The upper slide chuck is configured to hold an experimental slide via a vacuum mechanism to engagedly hold the experimental slide to the upper slide chuck while the moveable tooling arm is rotated about the hinge from an open-book position to a closed-book position.

Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

Abstract: Embodiments provide a slide assembly device having a static tooling base which is statically and solidly affixed to a base such as a table and a moveable tooling arm that is rotatable about a hinge connected to the static tooling base, so that moveable tooling arm rotates about the hinge in a manner similar to a book cover opening and closing. The embodiments further provide an upper slide chuck that is removably attachable to the moveable tooling arm and a lower slide receiver that is removably attachable to the static tooling base. The upper slide chuck is configured to hold an experimental slide via a vacuum mechanism to engagedly hold the experimental slide to the upper slide chuck while the moveable tooling arm is rotated about the hinge from an open-book position to a closed-book position.

Abstract: A method and a device for producing a metal strip by continuous casting and rolling, in which a thin slab is initially cast into a casting machine, and is subsequently rolled in at least one rolling train using primary heat from the casting cycle. The cast thin slab is passed between the casting machine and the at least one rolling train and at least one holding oven as well as at least one induction oven. The holding oven and the induction oven are activated or deactivated according to a selected mode of operation, that is, a first mode of operation for the continuous production of the metal strip and a second mode of operation for the discontinuous production of the metal strip.

Abstract: A method of manufacturing a metal strip includes casting a slab (3) or preliminary strip (3?) in a casting machine (2) and subsequently rolling the cast slab (3) or preliminary strip (3?) in at least one rolling train (4, 5) in a first operating mode with the at least one rolling train being connected with the casting machine for continuously manufacturing the metal strip, and in a second operating mode removing the cast slab (3) or preliminary strip (3?) from the main transport line (6) with a shuttle system arranged between the casting machine (2) and the at least one rolling train (4, 5), storing the removed slab (3) or preliminary strip (3?), and subsequently transporting the removed slab (3) or preliminary strip back into the main transport line, with the removed slab (3) or preliminary strip (3?) being heated to a desired temperature or maintained at a desired temperature prior to the transport back into the main transport line (6) for discontinuously manufacturing the metal strip.

Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.

Abstract: The invention relates to a method for producing a metal strip (1) by continuous casting and rolling. According to said method, a thin slab (3) is initially cast into a casting machine (2), which is subsequently rolled in at least one rolling train (4, 5) using primary heat from the casting cycle. According to the invention, in order to improve the functionality of the continuous casting and rolling installation, the cast thin slab (3) is passed between the casting machine (2) and the at least one rolling train (4, 5) and at least one holding oven (6) as well as at least one induction oven (7). The holding oven (6) and the induction oven (7) are activated or deactivated according to a selected mode of operation, that is, a first mode of operation for the continuous production of the metal strip (1) and a second mode of operation for the discontinuous production of the metal strip (1). The invention further relates to a device for producing a metal strip by continuous casting and rolling.