Patents by Inventor Stephan Kraemer
Stephan Kraemer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250147022Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.Type: ApplicationFiled: January 10, 2025Publication date: May 8, 2025Applicant: SomaLogic Operating Co., Inc.Inventors: Glenn Sanders, Stephan Kraemer, Evaldas Katilius, Edgar Olivas
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Patent number: 12134798Abstract: Methods of detecting a leak from a subarray of a microarray chip, kits of components that facilitate leak detection, and microarray chips configured for leak detection are disclosed herein. The methods include positioning, within the given subarray, a sample solution, which includes dissolved sample molecules (DSMs) that define a dissolved sample oligonucleotide sequence and dissolved leak detection molecules (DLDMs) that define a predetermined dissolved leak detection oligonucleotide sequence. The methods also include detecting the DLDMs within a region of the microarray chip that is external the given subarray. The kits of components include the microarray chip and DLDMs. The microarray chips includes a plurality of subarrays and a leak detection region that is at least partially external the plurality of subarrays.Type: GrantFiled: December 6, 2023Date of Patent: November 5, 2024Assignee: SomaLogic Operating Co., Inc.Inventors: Rachel Woolaver Trahan, Jon H. Monserud, Maarten Rutgers, Jason Cleveland, Barry Vant-Hull, Stephan Kraemer
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Publication number: 20210247387Abstract: Methods, devices, reagents and kits designed to improve the performance of proteomic based assays are provided. Such methods have a wide utility in proteomic applications for research and development, diagnostics and therapeutics by providing for a reduction or elimination of background signal and improved specificity for protein binding reagents in a multiplex assay formats.Type: ApplicationFiled: June 19, 2019Publication date: August 12, 2021Applicant: SOMALOGIC, INC.Inventors: Stephan KRAEMER, Evaldas KATILIUS, Dominic ZICHI
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Publication number: 20210239692Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.Type: ApplicationFiled: March 30, 2021Publication date: August 5, 2021Inventors: Glenn Sanders, Stephan Kraemer, Evaldas Katilius, EDGAR OLIVAS
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Publication number: 20180224444Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.Type: ApplicationFiled: November 30, 2017Publication date: August 9, 2018Inventors: Glenn Sanders, Stephan Kraemer, Evaldas Katilius
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Publication number: 20170176422Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.Type: ApplicationFiled: March 9, 2017Publication date: June 22, 2017Inventors: Glenn Sanders, Stephan Kraemer, Evaldas Katilius
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Patent number: 9404919Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.Type: GrantFiled: February 10, 2014Date of Patent: August 2, 2016Assignee: SOMALOGIC, INC.Inventors: Daniel J. Schneider, Dan Nieuwlandt, Bruce Eaton, Martin Stanton, Shashi Gupta, Stephan Kraemer, Dominic Zichi, Larry Gold
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Patent number: 9314797Abstract: Embodiments provide a slide assembly device having a static tooling base which is statically and solidly affixed to a base such as a table and a moveable tooling arm that is rotatable about a hinge connected to the static tooling base, so that moveable tooling arm rotates about the hinge in a manner similar to a book cover opening and closing. The embodiments further provide an upper slide chuck that is removably attachable to the moveable tooling arm and a lower slide receiver that is removably attachable to the static tooling base. The upper slide chuck is configured to hold an experimental slide via a vacuum mechanism to engagedly hold the experimental slide to the upper slide chuck while the moveable tooling arm is rotated about the hinge from an open-book position to a closed-book position.Type: GrantFiled: December 1, 2014Date of Patent: April 19, 2016Assignee: SomaLogic, Inc.Inventors: Jeff Aldred, Alexis Stuart Foreman, Tracy R Keeney, Jonathan Vaught, Chris Bock, Stephan Kraemer
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Publication number: 20150158029Abstract: Embodiments provide a slide assembly device having a static tooling base which is statically and solidly affixed to a base such as a table and a moveable tooling arm that is rotatable about a hinge connected to the static tooling base, so that moveable tooling arm rotates about the hinge in a manner similar to a book cover opening and closing. The embodiments further provide an upper slide chuck that is removably attachable to the moveable tooling arm and a lower slide receiver that is removably attachable to the static tooling base. The upper slide chuck is configured to hold an experimental slide via a vacuum mechanism to engagedly hold the experimental slide to the upper slide chuck while the moveable tooling arm is rotated about the hinge from an open-book position to a closed-book position.Type: ApplicationFiled: December 1, 2014Publication date: June 11, 2015Inventors: Jeff Aldred, Alexis Stuart Foreman, Tracy R. Keeney, Jonathan Vaught, Chris Bock, Stephan Kraemer
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Publication number: 20150141259Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.Type: ApplicationFiled: June 7, 2013Publication date: May 21, 2015Inventors: Glenn Sanders, Stephan Kraemer, Evaldas Katilius
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Patent number: 8925175Abstract: Embodiments provide a slide assembly device having a static tooling base which is statically and solidly affixed to a base such as a table and a moveable tooling arm that is rotatable about a hinge connected to the static tooling base, so that moveable tooling arm rotates about the hinge in a manner similar to a book cover opening and closing. The embodiments further provide an upper slide chuck that is removably attachable to the moveable tooling arm and a lower slide receiver that is removably attachable to the static tooling base. The upper slide chuck is configured to hold an experimental slide via a vacuum mechanism to engagedly hold the experimental slide to the upper slide chuck while the moveable tooling arm is rotated about the hinge from an open-book position to a closed-book position.Type: GrantFiled: August 17, 2012Date of Patent: January 6, 2015Assignee: SomaLogic, Inc.Inventors: Jeff Aldred, Tracy R Keeney, Jonathan Vaught, Chris Bock, Stephan Kraemer, Alexis Stuart Foreman
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Publication number: 20140249043Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.Type: ApplicationFiled: February 10, 2014Publication date: September 4, 2014Applicant: SOMALOGIC, INC.Inventors: Daniel J. Schneider, Dan Nieuwlandt, Bruce Eaton, Martin Stanton, Shashi Gupta, Stephan Kraemer, Dominic Zichi, Larry Gold
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Publication number: 20140201965Abstract: Embodiments provide a slide assembly device having a static tooling base which is statically and solidly affixed to a base such as a table and a moveable tooling arm that is rotatable about a hinge connected to the static tooling base, so that moveable tooling arm rotates about the hinge in a manner similar to a book cover opening and closing. The embodiments further provide an upper slide chuck that is removably attachable to the moveable tooling arm and a lower slide receiver that is removably attachable to the static tooling base. The upper slide chuck is configured to hold an experimental slide via a vacuum mechanism to engagedly hold the experimental slide to the upper slide chuck while the moveable tooling arm is rotated about the hinge from an open-book position to a closed-book position.Type: ApplicationFiled: August 17, 2012Publication date: July 24, 2014Applicant: SOMALOGIC, INC.Inventors: Jeff Aldred, Alexis Stuart Foreman, Tracy R. Keeney, Jonathan Vaught, Chris Bock, Stephan Kraemer
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Publication number: 20110136099Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.Type: ApplicationFiled: December 2, 2010Publication date: June 9, 2011Applicant: SOMALOGIC, INC.Inventors: Daniel J. Schneider, Dan Nieuwlandt, Bruce Eaton, Marty Stanton, Shashi Gupta, Stephan Kraemer, Dominic Zichi, Larry Gold
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Patent number: 7855054Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.Type: GrantFiled: July 17, 2008Date of Patent: December 21, 2010Assignee: SomaLogic, Inc.Inventors: Daniel J. Schneider, Dan Nieuwlandt, Bruce Eaton, Marty Stanton, Shashi Gupta, Stephan Kraemer, Dominic Zichi, Larry Gold
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Publication number: 20100147484Abstract: The invention pertains to a method for manufacturing a metal strip (1) by means of continuous casting and rolling, wherein a thin slab (3) is initially cast in a casting machine (2) and this thin slab is subsequently rolled in at least one rolling train (4, 5) by utilizing the primary heat of the casting process, wherein a continuous manufacture of the metal strip (1) (continuous rolling) can be realized in a first operating mode by directly coupling the casting machine (2) to the at least one rolling train (4, 5), and wherein a discontinuous manufacture of the metal strip (1) (batch rolling) can be realized in a second operating mode by decoupling the casting machine (2) from the at least one rolling train (4, 5).Type: ApplicationFiled: August 21, 2008Publication date: June 17, 2010Inventors: Dieter Rosenthal, Stephan Kraemer, Christoph Klein, Juergen Seidel, Wolfgang-Dietmar Hackenberg
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Publication number: 20090042206Abstract: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer). The methods described create a nucleic acid surrogate for a non-nucleic acid target, thus allowing the wide variety of nucleic acid technologies, including amplification, to be applied to a broader range of desired targets, especially protein targets. The disclosure further describes aptamer constructs that facilitate the use of aptamers in a variety of analytical detection applications.Type: ApplicationFiled: July 17, 2008Publication date: February 12, 2009Applicant: SOMALOGIC, INC.Inventors: Daniel J. Schneider, Dan Nieuwlandt, Bruce Eaton, Marty Stanton, Shashi Gupta, Stephan Kraemer, Dominic Zichi, Larry Gold
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Patent number: 6314940Abstract: In a fuel feed system for a spark-ignition internal combustion engine, which system has at least a first injection valve, which is arranged in or on a cylinder head and to which fuel is fed under pressure for discharging directly into a combustion chamber of the internal combustion engine, at least one further injection valve is provided in an engine intake passage to discharge, in certain operating ranges of the internal combustion engine, fuel into the intake passage of the internal combustion engine in addition to the discharge of the fuel of the first injection valve into the cylinder, and the first injection valve is designed for fuel injection volume lower than that required for full power operation of the engine.Type: GrantFiled: March 10, 2000Date of Patent: November 13, 2001Assignee: DaimlerChrysler AGInventors: Juergen Frey, Guenter Karl, Stephan Kraemer
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Patent number: 5983853Abstract: In a method of providing an ignitable fuel/air mixture in the combustion chambers of the various cylinders of an internal combustion engine with direct fuel injection wherein fuel is injected into the combustion chambers by way of injectors including injection nozzles with valve members for controllably opening and closing the injection nozzles, the valve member opening strokes and the valve member opening times are variably adjusted depending on specific engine operating conditions.Type: GrantFiled: October 15, 1997Date of Patent: November 16, 1999Assignee: Daimler - Benz AGInventors: Klaus Roessler, Stephan Kraemer, Guenter Karl, Christian Enderle