Patents by Inventor Stephan RIGOL

Stephan RIGOL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of disorazoles and analogs thereof as potent anticancer agents
    Patent number: 11465997
    Abstract: In one aspect, the present disclosure provides disorazole analogs of the formula: Formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: October 11, 2022
    Assignee: William Marsh Rice University
    Inventors: Kyriacos C. Nicolaou, Gabriel Bellavance, Marek Buchman, Kiran Kumar Pulukuri, Stephan Rigol
  • Tubulysin analogues as anticancer agents and payloads for antibody-drug conjugates and methods of treatment therewith
    Patent number: 11274124
    Abstract: In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: March 15, 2022
    Assignee: William Marsh Rice University
    Inventors: Kyriacos C. Nicolaou, Rohan Diliprao Erande, Dionisios Vourloumis, Kiran Kumar Pulukuri, Stephan Rigol
  • TUBULYSIN ANALOGUES AS ANTICANCER AGENTS AND PAYLOADS FOR ANTIBODY-DRUG CONJUGATES AND METHODS OF TREATMENT THEREWITH
    Publication number: 20210188906
    Abstract: In one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
    Type: Application
    Filed: November 28, 2018
    Publication date: June 24, 2021
    Applicant: William Marsh Rice University
    Inventors: Kyriacos C. NICOLAOU, Rohan Diliprao ERANDE, Dionisios VOURLOUMIS, Kiran Kumar PULUKURI, Stephan RIGOL
  • SYNTHESIS OF DISORAZOLES AND ANALOGS THEREOF AS POTENT ANTICANCER AGENTS
    Publication number: 20210155616
    Abstract: In one aspect, the present disclosure provides disorazole analogs of the formula: Formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
    Type: Application
    Filed: June 21, 2018
    Publication date: May 27, 2021
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Kyriacos C. NICOLAOU, Gabriel BELLAVANCE, Marek BUCHMAN, Kiran Kumar PULUKURI, Stephan RIGOL