Patents by Inventor Stephan Stern

Stephan Stern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETING THE CHOLECYSTOKININ-B RECEPTOR FOR IMAGING AND EARLY DETECTION OF PANCREATIC CANCER AND PRE-CANCEROUS LESIONS
    Publication number: 20240252696
    Abstract: A method that includes detecting the presence of a pancreatic intraepithelial neoplasia lesion in a subject in vivo comprising administering to the subject a construct, or a pharmaceutically acceptable salt thereof, wherein the construct comprises: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized; (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and (c) a detectable moiety complexed with, or conjugated to, the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized.
    Type: Application
    Filed: May 26, 2021
    Publication date: August 1, 2024
    Applicants: Georgetown University, The USA as represented by the Secretary, Department of Health and Human Services
    Inventors: Jill P. Smith, Stephan Stern
  • Nanoparticle to target cancer
    Patent number: 11696922
    Abstract: A construct, or a pharmaceutically acceptable salt thereof, comprising: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized; (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and (c) a siRNA complexed with the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: July 11, 2023
    Assignees: Georgetown University, The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Jill P. Smith, Stephan Stern, Abdullah Mahmud
  • NANOPARTICLE TO TARGET CANCER
    Publication number: 20220211738
    Abstract: A construct, or a pharmaceutically acceptable salt thereof, comprising: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized; (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and (c) a siRNA complexed with the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized.
    Type: Application
    Filed: December 17, 2021
    Publication date: July 7, 2022
    Applicants: Georgetown University, The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Jill P. Smith, Stephan Stern, Abdullah Mahmud
  • Nanoparticle to target cancer
    Patent number: 11246881
    Abstract: A construct, or a pharmaceutically acceptable salt thereof, comprising: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized; (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and (c) a siRNA complexed with the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: February 15, 2022
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Georgetown University
    Inventors: Jill P. Smith, Stephan Stern, Abdullah Mahmud
  • NANOPARTICLE TO TARGET CANCER
    Publication number: 20190076457
    Abstract: A construct, or a pharmaceutically acceptable salt thereof, comprising: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized; (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and (c) a siRNA complexed with the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized.
    Type: Application
    Filed: March 15, 2017
    Publication date: March 14, 2019
    Applicants: Georgetown University, The United States of America, as represented by the Secretary, Department of Health & Human Servic
    Inventors: Jill P. Smith, Stephan Stern, Abdullah Mahmud