Patents by Inventor Stephan Thierfelder

Stephan Thierfelder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing heterologous bi-specific antibodies
    Patent number: 5945311
    Abstract: In a method for producing heterologous bi-specific antibodies, a quadroma is provided which is fused from hybridromas one of which generates antibodies that have an affinity to the binding site of protein A and another of which generates antibodies that have a weaker or no affinity to the binding domain of protein A, by multiplying and cultivating the quadromas and by eluting the bi-specific antibodies in a pH range at least 0.5 units above the pH value at which the antibodies with greater affinity to the binding domain of protein A are still bonded.
    Type: Grant
    Filed: November 29, 1996
    Date of Patent: August 31, 1999
    Assignee: GSF--Forschungszentrumfur Umweltund Gesundheit
    Inventors: Horst Lindhofer, Stephan Thierfelder