Abstract: The invention provides a modified T cell, or an isolated population of immune cells expressing a CXCR3 isoform selected from CXCR3A, CXCR3B, and CXCR3alt, and optionally, further expressing transgenes comprising an artificial T cell receptor, and/or a CXCR3 ligand, for use as a medicament. The invention also provides the methods to obtain said cells, or populations of cells from a plurality of immune cells derived from a human subject. The invention also relates to assessment of CXCR3 splice variants and its ligands CXCL9, CXCL10, and CXCL11 in muscle-invasive bladder cancer (MIBC) patients, to enable patients to be stratified for their predicted response to a chemotherapy drug treatment, or clinical outcome.

Abstract: A modular valve for free-flowing media, with a main module with a valve housing and an electromagnet, a dosing module with a closure member which is movable by means of the electromagnet and which closes a dispensing opening of the dosing module, and a valve lift adjustment module for adjusting the valve lift, which valve lift adjustment module comprises an elongate abutment part which is arranged at least in part in a valve interior of the main module and is modifiable in its axial position in the valve interior, which abutment part limits the movement of the closure member in the direction of the valve lift adjustment module, the dosing module and the valve lift adjustment module being connected releasably to the main module in such a way that the dosing module and the valve lift adjustment module can each be replaced by another module of the same module type.

Abstract: A modular valve for free-flowing media, with a main module with a valve housing and an electromagnet, a dosing module with a closure member which is movable by means of the electromagnet and which closes a dispensing opening of the dosing module, and a valve lift adjustment module for adjusting the valve lift, which valve lift adjustment module comprises an elongate abutment part which is arranged at least in part in a valve interior of the main module and is modifiable in its axial position in the valve interior, which abutment part limits the movement of the closure member in the direction of the valve lift adjustment module, the dosing module and the valve lift adjustment module being connected releasably to the main module in such a way that the dosing module and the valve lift adjustment module can each be replaced by another module of the same module type.