Patents by Inventor Stephane A. Dumas

Stephane A. Dumas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide-based multimeric targeted contrast agents
    Patent number: 7238341
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: July 3, 2007
    Assignee: Epix Pharmaceuticals, Inc.
    Inventors: Zhaoda Zhang, John C. Amedio, Peter D. Caravan, Stephane Dumas, Andrew Kolodziej, Thomas J. McMurry
  • Polypeptide conjugates with extended circulating half-lives
    Patent number: 7186797
    Abstract: The present invention relates to compounds and methods for synthesizing compounds wherein the compounds exhibit extended circulating half-life in the blood. The increase in circulating half-life is achieved by conjugating polypeptides to binding groups that exhibit high affinity for human serum albumin.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: March 6, 2007
    Assignee: Epix Pharmaceuticals, Inc.
    Inventors: Theodore R. West, Thomas J McMurry, Stephane Dumas, Andrew Kolodziej
  • Hydroxypyridinone derivatives, metal complexes thereof and the use thereof for preparing conjugates with biomolecules
    Publication number: 20070003484
    Abstract: The invention relates to hydroxypyridinone derivatives, their metal complexes, their preparation and their use for preparing conjugates with biomolecules. The conjugates are suitable as contrast agents in NMR diagnosis. A high relaxivity is achieved and the NMRD maximum is raised through a specific design of the ligands.
    Type: Application
    Filed: December 20, 2005
    Publication date: January 4, 2007
    Inventors: Heribert Schmitt-Willich, Heiko Schirmer, Johannes Platzek, Stephane Dumas, Vincent Jacques, Thomas Brumby, Detlev Suelzle, Bernd Misselwitz
  • Conjugates of hydroxypyridinone derivative metal complexes with biomolecules and their use for MRI diagnosis
    Publication number: 20060292079
    Abstract: The invention relates to conjugates of hydroxypyridinone derivative metal complexes and to their preparation. The conjugates are suitable as contrast agents in NMR diagnosis. A high relaxivity is achieved and the NMRD maximum is raised through a specific design of the ligands.
    Type: Application
    Filed: December 20, 2005
    Publication date: December 28, 2006
    Inventors: Heribert Schmitt-Willich, Heiko Schirmer, Johannes Platzek, Stephane Dumas, Vincent Jacques, Thomas Brumby, Detlev Suelzle, Bernd Misselwitz
  • Bioactivated diagnostic imaging constrast agents
    Patent number: 7147837
    Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bioactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: December 12, 2006
    Assignee: Epix Pharmaceuticals, Inc.
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephen O. Dunham, Daniel M. Scott, David J. Parmelee, Stéphane Dumas
  • Bioactivated diagnostic imaging contrast agents
    Publication number: 20060275216
    Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bioactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
    Type: Application
    Filed: August 16, 2006
    Publication date: December 7, 2006
    Inventors: Randall Lauffer, Thomas McMurry, Stephen Dunham, Daniel Scott, David Parmelee, Stephane Dumas
  • Peptide-based multimeric targeted contrast agents
    Publication number: 20060039861
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Application
    Filed: April 4, 2005
    Publication date: February 23, 2006
    Inventors: Zhaoda Zhang, John Amedio, Peter Caravan, Stephane Dumas, Andrew Kolodziej, Thomas McMurry
  • Peptide-based multimeric targeted contrast agents
    Publication number: 20050074411
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Application
    Filed: February 25, 2004
    Publication date: April 7, 2005
    Inventors: Zhaoda Zhang, John Amedio, Peter Caravan, Stephane Dumas, Andrew Kolodziej, Thomas McMurry
  • Polypeptide conjugates with extended circulating half-lives
    Publication number: 20040254119
    Abstract: The present invention relates to compounds and methods for synthesizing compounds wherein the compounds exhibit extended circulating half-life in the blood. The increase in circulating half-life is achieved by conjugating polypeptides to binding groups that exhibit high affinity for human serum albumin.
    Type: Application
    Filed: July 15, 2004
    Publication date: December 16, 2004
    Inventors: Theodore R. West, Thomas J McMurry, Stephane Dumas, Andrew Kolodziej
  • Bioactivated diagnostic imaging constrast agents
    Publication number: 20040156785
    Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bioactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
    Type: Application
    Filed: January 16, 2004
    Publication date: August 12, 2004
    Applicant: Epix Medical , Inc., a Delaware corporation
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephen O. Dunham, Daniel M. Scott, David J. Parmelee, Stephane Dumas
  • Bioactivated diagnostic imaging contrast agents
    Patent number: 6709646
    Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bloactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: March 23, 2004
    Assignee: Epix Medical, Inc.
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephen O. Dunham, Daniel M. Scott, David J. Parmelee, Stéphane Dumas
  • Targeting multimeric imaging agents through multilocus binding
    Publication number: 20040005274
    Abstract: The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon binding to endogenous proteins or other physiologically relevant sites.
    Type: Application
    Filed: May 27, 2003
    Publication date: January 8, 2004
    Applicant: Epix Medical, Inc., a Delaware corporation
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephane Dumas, Andrew Kolodziej, John C. Amedio, Peter D. Caravan, Zhaoda Zhang, Shrikumar Nair, Robert M. Weisskoff
  • Targeting multimeric imaging agents through multilocus binding
    Patent number: 6652835
    Abstract: The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon binding to endogenous proteins or other physiologically relevant sites. The compounds consist of: a) two or more Image Enhancing Moieties (IEMs) (or signal-generating moiety) comprising multiple subunits; b) two or more Target Binding Moieties (TBMs), providing for in vivo localization and multimer rigidification; and c) a scaffold framework for attachment of the above moieties. d) optional linkers for attachment of the IEMs to scaffold. This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for contrast enhancement of diagnostic imaging.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: November 25, 2003
    Assignee: Epix Medical, Inc.
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephane Dumas, Andrew Kolodziej, John Amedio, Peter Caravan, Zhaoda Zhang
  • Peptide-based multimeric targeted contrast agents
    Publication number: 20030180222
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Application
    Filed: July 30, 2002
    Publication date: September 25, 2003
    Inventors: Zhaoda Zhang, John C. Amedio, Peter D. Caravan, Stephane Dumas, Andrew Kolodziej, Thomas J. McMurry
  • Bioactivated diagnostic imaging contrast agents
    Publication number: 20020034476
    Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bloactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
    Type: Application
    Filed: September 14, 2001
    Publication date: March 21, 2002
    Applicant: EPIX Medical, Inc.
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephen O. Dunham, Daniel M. Scott, David J. Parmelee, Stephane Dumas