Patents by Inventor Stephane A. Laporte

Stephane A. Laporte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prostaglandin-F2 alpha receptor modulators and uses thereof
    Patent number: 8802818
    Abstract: Prostaglandin-F2 alpha (PGF2?) receptor (FP) modulators of formula I, as well as the use of PGF2? receptor modulators for the treatment of conditions associated with FP activity such as preterm labor and colorectal cancer, are disclosed.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: August 12, 2014
    Inventors: William D. Lubell, Sylvain Chemtob, Terence E. Hebert, Audrey Claing, Stephane Laporte, Carine B. Bourguet, Eugenie Goupil, Xin Hou, Danae Tassy
  • PROSTAGLANDIN-F2 ALPHA RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20120309690
    Abstract: Prostaglandin-F2 alpha (PGF2?) receptor (FP) modulators of formula I, as well as the use of PGF2? receptor modulators for the treatment of conditions associated with FP activity such as preterm labor and colorectal cancer, are disclosed.
    Type: Application
    Filed: June 1, 2012
    Publication date: December 6, 2012
    Inventors: William D. LUBELL, Sylvain CHEMTOB, Terence E. HÉBERT, Audrey CLAING, Stephane LAPORTE, Carine B. BOURGUET, Eugenie GOUPIL, Xin HOU, Danae TASSY
  • Nucleic acid encoding G-protein coupled receptor with modified DRY motif
    Patent number: 7279324
    Abstract: The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have altered DRY motifs such that the modified GPCRs are constitutively desensitized. As such, the modified GPCRs of the present invention preferably localize to endocytic vesicles or endosomes in an agonist-independent manner. The invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: October 9, 2007
    Assignee: Duke University
    Inventors: Larry S. Barak, Robert H. Oakley, Marc G. Caron, Stephane A. Laporte, Alyson Wilbanks
  • Modified G-protein coupled receptors
    Patent number: 7214496
    Abstract: The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have carboxyl terminal tails comprising one or more sites of phosphorylation, preferably one or more clusters of phosphorylation sites. The modified GPCRs of the present invention may comprise a retained portion of a carboxyl-terminus region from a first GPCR fused to a polypeptide, wherein the polypeptide comprises the one or more clusters of phosphorylation. The present invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: May 8, 2007
    Assignee: Duke University
    Inventors: Robert H. Oakley, Lawrence S. Barak, Stephane A. Laporte, Marc G. Caron
  • Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
    Patent number: 7163800
    Abstract: The methods of the present invention allow the screening of a test composition for non-receptor-specific GPCR desensitization inhibitory activity. The methods involve screening a test composition for an indication of GPCR desensitization inhibitory activity against two or more GPCRs that are different from each other. When there is an indication that a particular test composition has GPCR desensitization inhibitory activity with respect to each of the two or more GPCRs that are different from one another, then, according to the present invention, there is an indication that the test composition has non-receptor-specific GPCR desensitization inhibitory activity.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: January 16, 2007
    Assignee: Molecular Devices Corporation
    Inventors: Robert H. Oakley, Lawrence S. Barak, Stephane A. Laporte, Marc G. Caron
  • Modified G-protein coupled receptors
    Patent number: 7018812
    Abstract: The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have carboxyl terminal tails comprising one or more sites of phosphorylation, preferably one or more clusters of phosphorylation sites. The modified GPCRs of the present invention may comprise a retained portion of a carboxyl-terminus region from a first GPCR fused to a polypeptide, wherein the polypeptide comprises the one or more clusters of phosphorylation. The present invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: March 28, 2006
    Assignee: Duke University
    Inventors: Robert H. Oakley, Lawrence S. Barak, Stephane A. Laporte, Marc G. Caron
  • Phosphoinositide 3-kinase mediated inhibition of GPCRs
    Publication number: 20060026702
    Abstract: The present invention relates to compounds that alter GPCR internalization and new methods for their identification. Compounds of this invention include modified phosphoinositide 3-kinase (PI3K), modified HEAT domain, modified ?-adrenergic receptor kinase 1 (?ARK1), as well as other peptides or small molecules that alter GPCR internalization. The present invention also includes the use of such compounds to treat GPCR-related diseases, such as cardiovascular disease, heart failure, asthma, nephrogenic diabetes insipidus, or hypertension.
    Type: Application
    Filed: July 30, 2004
    Publication date: February 2, 2006
    Applicant: DUKE UNIVERSITY
    Inventors: Howard Rockman, Sathyamangla Naga Prasad, Stephane Laporte, Larry Barak, Marc Caron
  • Modified G-protein coupled receptors
    Publication number: 20050106623
    Abstract: The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have carboxyl terminal tails comprising one or more sites of phosphorylation, preferably one or more clusters of phosphorylation sites. The modified GPCRs of the present invention may comprise a retained portion of a carboxyl-terminus region from a first GPCR fused to a polypeptide, wherein the polypeptide comprises the one or more clusters of phosphorylation. The present invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRS.
    Type: Application
    Filed: December 30, 2004
    Publication date: May 19, 2005
    Inventors: Robert Oakley, Lawrence Barak, Stephane Laporte, Marc Caron
  • Methods of screening compositions for G protein -coupled receptor desensitization inhibitory activity
    Publication number: 20040091946
    Abstract: The methods of the present invention allow the screening of a test composition for non-receptor-specific GPCR desensitization inhibitory activity. The methods involve screening a test composition for an indication of GPCR desensitization inhibitory activity against two or more GPCRs that are different from each other. When there is an indication that a particular test composition has GPCR desensitization inhibitory activity with respect to each of the two or more GPCRs that are different from one another, then, according to the present invention, there is an indication that the test composition has non-receptor-specific GPCR desensitization inhibitory activity.
    Type: Application
    Filed: August 1, 2003
    Publication date: May 13, 2004
    Inventors: Robert H. Oakley, Lawrence S. Barak, Stephane A. Laporte, Marc G. Caron
  • Phosphoinositide 3-kinase mediated inhibition of GPCRs
    Publication number: 20030182669
    Abstract: The present invention relates to compounds that alter GPCR internalization and new methods for their identification. Compounds of this invention include modified phosphoinositide 3-kinase (PI3K), modified HEAT domain, modified &bgr;-adrenergic receptor kinase 1 (&bgr;ARK1), as well as other peptides or small molecules that alter GPCR internalization. The present invention also includes the use of such compounds to treat GPCR-related diseases, such as cardiovascular disease, heart failure, asthma, nephrogenic diabetes insipidus, or hypertension.
    Type: Application
    Filed: March 19, 2002
    Publication date: September 25, 2003
    Inventors: Howard A. Rockman, Sathyamangla V. Naga Prasad, Stephane A. Laporte, Larry S. Barak, Marc G. Caron
  • Constitutively desensitized G protein-coupled receptors
    Publication number: 20030049643
    Abstract: The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have altered DRY motifs such that the modified GPCRs are constitutively desensitized. As such, the modified GPCRs of the present invention preferably localize to endocytic vesicles or endosomes in an agonist-independent manner. The invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.
    Type: Application
    Filed: January 22, 2002
    Publication date: March 13, 2003
    Inventors: Larry S. Barak, Robert H. Oakley, Marc G. Caron, Stephane A. Laporte, Alyson Wilbanks
  • Modified G-protein coupled receptors
    Publication number: 20020106739
    Abstract: The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have carboxyl terminal tails comprising one or more sites of phosphorylation, preferably one or more clusters of phosphorylation sites. The modified GPCRs of the present invention may comprise a retained portion of a carboxyl-terminus region from a first GPCR fused to a polypeptide, wherein the polypeptide comprises the one or more clusters of phosphorylation. The present invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.
    Type: Application
    Filed: November 5, 2001
    Publication date: August 8, 2002
    Inventors: Robert H. Oakley, Lawrence S. Barak, Stephane A. Laporte, Marc G. Caron