Patents by Inventor Stephane Blesa

Stephane Blesa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variant endoglucanases
    Patent number: 9637728
    Abstract: The present invention provides T. reesei endoglucanase I variants exhibiting improved cellulase and/or xylanase activity, in particular at 30° C. and/or pH 6. These variants are particularly useful in industrial processes comprising simultaneous degradation of cellulosic biomass into monomeric sugars and fermentation of said sugars, for example to produce ethanol.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: May 2, 2017
    Assignee: BIOMETHODES
    Inventors: Stéphane Blesa, Céline Coursange, Bruno Winter
  • NOVEL VARIANT TRICHODERMA REESEI ENDOGLUCANASES
    Publication number: 20160208232
    Abstract: The present invention provides T. reesei endoglucanase I variants exhibiting improved cellulase and/or xylanase activity, in particular at 30° C. and/or pH 6. These variants are particularly useful in industrial processes comprising simultaneous degradation of cellulosic biomass into monomeric sugars and fermentation of said sugars, for example to produce ethanol.
    Type: Application
    Filed: July 25, 2014
    Publication date: July 21, 2016
    Inventors: STÉPHANE BLESA, CÉLINE COURSANGE, BRUNO WINTER
  • Enhanced phytase variants
    Patent number: 9109210
    Abstract: The present invention provides the field of enhancing proteins and in particular to that of proteins enhanced by molecular change. It provides a variant of a phytase that is termed enhanced in that is has better thermostability and/or activity than the original phytase. The invention also provides a nucleic acid coding for said variant, a cassette or an expression vector containing said variant, a host cell expressing said variant, a composition comprising said variant and uses thereof, principally in the preparation of food additives and animal feed.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: August 18, 2015
    Assignee: BIOMETHODES
    Inventors: Stephane Blesa, Helene Chautard, Marc Delcourt, Laurent Mesta, Bruno Winter
  • VIII factors for the treatment of type A hemophilia
    Patent number: 8623824
    Abstract: The present invention relates to improved human FVIII variants having at least one substitution in the A2 and/or C2 domain. The present invention also relates to their uses in the treatment of hemophilia A, particularly in patients with inhibitors.
    Type: Grant
    Filed: February 22, 2008
    Date of Patent: January 7, 2014
    Assignees: Biomethodes, Hospices Civils de Lyon
    Inventors: Didier Saboulard, Jean-Luc Plantier, Marc Delcourt, Claude Negrier, Thierry Menguy, Stephane Blesa, Sylvie Marin
  • ENHANCED PHYTASE VARIANTS
    Publication number: 20130122567
    Abstract: The present invention provides the field of enhancing proteins and in particular to that of proteins enhanced by molecular change. It provides a variant of a phytase that is termed enhanced in that is has better thermostability and/or activity than the original phytase. The invention also provides a nucleic acid coding for said variant, a cassette or an expression vector containing said variant, a host cell expressing said variant, a composition comprising said variant and uses thereof, principally in the preparation of food additives and animal feed.
    Type: Application
    Filed: July 1, 2010
    Publication date: May 16, 2013
    Applicant: BIOMETHODES
    Inventors: Stephane Blesa, Helene Chautard, Marc Delcourt, Laurent Mesta, Bruno Winter
  • Novel VIII Factors for the Treatment of Type A Hemophilia
    Publication number: 20100311659
    Abstract: The present invention relates to improved human FVIII variants having at least one substitution in the A2 and/or C2 domain. The present invention also relates to their uses in the treatment of hemophilia A, particularly in patients with inhibitors.
    Type: Application
    Filed: February 22, 2008
    Publication date: December 9, 2010
    Applicants: BIOMETHODES, HOSPICES CIVILS DE LYON
    Inventors: Didier Saboulard, Jean-Luc Plantier, Marc Delcourt, Claude Negrier, Thierry Menguy, Stephane Blesa, Sylvie Marin
  • Method for massive directed mutagenesis
    Patent number: 7202086
    Abstract: The invention concerns the field of molecular biology and more particularly that of mutagenesis. It concerns a method of high-rate directed mutagenesis, that is the formation of numerous directed mutants in reduced time and with reduced number of steps. Said method is therefore referred to as massive mutagenesis.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: April 10, 2007
    Assignee: Biomethodes
    Inventors: Marc Delcourt, Stephane Blesa
  • Method for massive directed mutagenesis
    Publication number: 20040048268
    Abstract: The invention concerns the field of molecular biology and more particularly that of mutagenesis. It concerns a method of high-rate directed mutagenesis, that is the formation of numerous directed mutants in reduced time and with reduced number of steps. Said method is therefore referred to as massive mutagenesis.
    Type: Application
    Filed: August 6, 2003
    Publication date: March 11, 2004
    Inventors: Marc Delcourt, Stephane Blesa