Patents by Inventor Stephane Brezillion

Stephane Brezillion has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of identifying a ligand, an agonist, and an antagonist of G protein coupled receptor GPR86 (P2Y13)
    Patent number: 6946244
    Abstract: The present invention is related to a recombinant cell expressing a nucleotide sequence encoding a G protein coupled receptor having an amino acid sequence which presents more than 70% sequence identity with SEQ ID.NO.1 as well as to a drug screening method and kit using the orphan G protein coupled receptor GPR86, identified hereafter as receptor for ADP (P2Y13) and a homologous sequence, the corresponding polynucleotide and said recombinant cell to identify agonist, inverse agonist and antagonist compounds applicable to a diagnostic, prevention and/or treatment of various diseases and disorders.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: September 20, 2005
    Assignee: Euroscreen, S.A.
    Inventors: Didier Communi, Nathalie Suarez, Michel Detheux, Stephane Brezillion, Vincent Lannoy, Marc Parmentier, Jean-Marie Boeynaems
  • Ligands for G protein coupled receptor GPR7 and GPR8 and uses thereof
    Publication number: 20030232756
    Abstract: The present invention is related to the identification of a family of polypeptide ligands that bind both the GPR7 and GPR8 G-protein coupled receptors, and to their use in screening methods for the identification of modulators of GPR7/8 receptor function and for diagnostic and therapeutic applications. The invention further relates to kits which use these orphan G protein coupled receptors and their ligands to identify agonist and antagonist compounds applicable to the diagnosis, prevention and/or treatment of diseases and disorders related to GPR7/8 receptor function or dysfunction.
    Type: Application
    Filed: March 31, 2003
    Publication date: December 18, 2003
    Applicant: Euroscreen, S.A.
    Inventors: Stephane Brezillion, Vincent Lannoy, Vincent Dupriez, Jean-Denis Franssen, Michel Detheux, Marc Parmentier, Emmanuel Le Poul
  • Natural ligand for orphan G protein coupled receptor GPR86 and methods of use
    Publication number: 20030050235
    Abstract: The present invention is related to a recombinant cell expressing a nucleotide sequence encoding a G protein coupled receptor having an amino acid sequence which presents more than 70% sequence identity with SEQ ID.NO.1 as well as to a drug screening method and kit using the orphan G protein coupled receptor GPR86, identified hereafter as receptor for ADP (P2Y13) and a homologous sequence, the corresponding polynucleotide and said recombinant cell to identify agonist, inverse agonist and antagonist compounds applicable to a diagnostic, prevention and/or treatment of various diseases and disorders.
    Type: Application
    Filed: August 7, 2001
    Publication date: March 13, 2003
    Inventors: Didier Communi, Nathalie Suarez, Michel Detheux, Stephane Brezillion, Vincent Lannoy, Marc Parmentier, Jean-Marie Boeynaems