Patents by Inventor Stephane Claude
Stephane Claude has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11926863Abstract: A method of analyzing single biological particles, such as cells or nuclei, that maintains the single biological particles in a state of relative isolation during decrosslinking and subsequent processing is provided. In the case of cells, the method prevents cellular analytes from each individual cell from leaving the cell site and diffusing toward adjacent cells, while permitting transmission of a decrosslinking agent, followed by processing of the cellular analytes from the individual cells by barcoding and/or imaging of the cellular analytes.Type: GrantFiled: February 26, 2021Date of Patent: March 12, 2024Assignee: 10x Genomics, Inc.Inventor: Stephane Claude Boutet
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Publication number: 20240075701Abstract: The facility comprises a tire-building station that is configured to form an uncured tire on a core. A curing station is configured to cure the assembly formed by the core and the uncured tire so as to obtain a cured annular tire. An extraction station is configured to separate, after the curing operation, the cured tire from the core. The curing station has a first, heating, thermal source which presses against the exchange face of the core for the curing operation and is then dissociated from the core and remains in the curing station in order to leave the exchange face free again when the core and the cured tire are transferred to the extraction station so that a second, refrigerating, thermal source of the extraction station takes the place of the first thermal source in contact with the exchange face of the core so as to cool the core.Type: ApplicationFiled: October 21, 2021Publication date: March 7, 2024Applicant: Compagnie Generale Des Etablissements MichelinInventors: David BOUCHEREAU, Jean MECHIN, Francois ROUYET, Jean-Claude DELORME, Stephane BARJON
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Publication number: 20230203577Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.Type: ApplicationFiled: August 24, 2022Publication date: June 29, 2023Inventors: Phillip Belgrader, Zachary Bent, Rajiv Bharadwaj, Vijay Kumar Sreenivasa Gopalan, Josephine Harada, Christopher Hindson, Mohammad Rahimi Lenji, Michael Ybarra Lucero, Geoffrey McDermott, Elliott Meer, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Serge Saxonov, John R. Stuelpnagel, Jessica Michele Terry, Tobias Daniel Wheeler, Indira Wu, Solongo Batjargal Ziraldo, Stephane Claude Boutet, Sarah Taylor, Niranjan Srinivas
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Publication number: 20220348901Abstract: Devices, kits, and their methods of use for lysing and/or purifying biological particles, e.g., nuclei are provided. One or more thixotropic layers can be employed in a vessel to purify biological particles. A device with sharp features may be employed to lyse biological particles or the contents thereof.Type: ApplicationFiled: December 15, 2021Publication date: November 3, 2022Inventors: Stephane Claude BOUTET, Alireza SALMANZADEH, Michael GIBBONS
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Publication number: 20220236258Abstract: Provided herein are methods and systems for measuring secreted cytokines or other analytes from single cells. The methods disclosed herein include the use of analyte-specific and/or barcoded binding agents (e.g., antibodies) and beads in partitions (e.g., droplets or wells) to measure such analytes on a single cell basis. Further described herein are methods comprising the use of hydrogel-encapsulated cells (e.g., cell beads) to measure secreted and/or cellular analytes from single cells.Type: ApplicationFiled: April 8, 2022Publication date: July 28, 2022Inventors: Geoffrey MCDERMOTT, Sarah TAYLOR, Stephane Claude BOUTET, Wyatt James MCDONNELL, Michael John Terry STUBBINGTON
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Publication number: 20220228220Abstract: The present disclosure provides methods, systems, and compositions for parallel processing of nucleic acid samples. Methods and systems of the present disclosure comprise the use of sample-specific barcode sequences, which facilitate the multiplexing of samples, detection of discrete cell populations within a pooled population, and detection of partitions comprising more than one cell.Type: ApplicationFiled: August 31, 2021Publication date: July 21, 2022Inventors: Stephane Claude Boutet, Michael Ybarra Lucero, Elliott Meer, Tarjei Sigurd Mikkelsen, Katherine Pfeiffer, Sarah Taylor, Niranjan Srinivas
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Publication number: 20220106641Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.Type: ApplicationFiled: September 13, 2021Publication date: April 7, 2022Inventors: Phillip BELGRADER, Zachary BENT, Rajiv BHARADWAJ, Vijay Kumar Sreenivasa GOPALAN, Josephine HARADA, Christopher HINDSON, Mohammad Rahimi LENJI, Michael Ybarra LUCERO, Geoffrey McDERMOTT, Elliott MEER, Tarjei Sigurd MIKKELSEN, Christopher Joachim O'KEEFFE, Katherine PFEIFFER, Andrew D. PRICE, Paul RYVKIN, Serge SAXONOV, John R. STUELPNAGEL, Jessica Michele TERRY, Tobias Daniel WHEELER, Indira WU, Solongo Batjargal ZIRALDO, Stephane Claude BOUTET, Sarah TAYLOR, Niranjan SRINIVAS
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Patent number: 11180805Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.Type: GrantFiled: October 29, 2020Date of Patent: November 23, 2021Assignee: 10X GENOMICS, INCInventors: Michael Ybarra Lucero, Tarjei Sigurd Mikkelsen, Katherine Pfeiffer, Stephane Claude Boutet
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Publication number: 20210140969Abstract: The present disclosure provides methods, systems, and compositions for parallel processing of nucleic acid samples. Methods and systems of the present disclosure comprise the use of sample-specific barcode sequences, which facilitate the multiplexing of samples, detection of discrete cell populations within a pooled population, and detection of partitions comprising more than one cell.Type: ApplicationFiled: June 5, 2020Publication date: May 13, 2021Inventors: Stephane Claude Boutet, Michael Ybarra Lucero, Tarjei Sigurd Mikkelsen, Katherine Pfeiffer
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Publication number: 20210130892Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.Type: ApplicationFiled: October 29, 2020Publication date: May 6, 2021Inventors: Phillip Belgrader, Zachary Bent, Rajiv Bharadwaj, Vijay Kumar Sreenivasa Gopalan, Josephine Harada, Christopher Hindson, Mohammad Rahimi Lenji, Michael Ybarra Lucero, Geoffrey McDermott, Elliott Meer, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Serge Saxonov, John R. Stuelpnagel, Jessica Michele Terry, Tobias Daniel Wheeler, Indira Wu, Solongo Batjargal Ziraldo, Stephane Claude Boutet, Sarah Taylor, Niranjan Srinivas
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Patent number: 10858702Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.Type: GrantFiled: June 17, 2019Date of Patent: December 8, 2020Assignee: 10X GENOMICS, INC.Inventors: Michael Ybarra Lucero, Tarjei Sigurd Mikkelsen, Katherine Pfeiffer, Stephane Claude Boutet
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Patent number: 10815525Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.Type: GrantFiled: June 12, 2019Date of Patent: October 27, 2020Assignee: 10X GENOMICS, INC.Inventors: Michael Ybarra Lucero, Tarjei Sigurd Mikkelsen, Katherine Pfeiffer, Stephane Claude Boutet
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Publication number: 20200291481Abstract: The present disclosure provides methods, systems, and compositions for parallel processing of nucleic acid samples. Methods and systems of the present disclosure comprise the use of sample-specific barcode sequences, which facilitate the multiplexing of samples, detection of discrete cell populations within a pooled population, and detection of partitions comprising more than one cell.Type: ApplicationFiled: October 10, 2019Publication date: September 17, 2020Inventors: Stephane Claude Boutet, Michael Ybarra Lucero, Tarjei Sigurd Mikkelsen, Katherine Pfeiffer
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Publication number: 20200002763Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.Type: ApplicationFiled: June 12, 2019Publication date: January 2, 2020Inventors: Phillip Belgrader, Zachary Bent, Rajiv Bharadwaj, Vijay Kumar Sreenivasa Gopalan, Josephine Harada, Christopher Hindson, Mohammad Rahimi Lenji, Michael Ybarra Lucero, Geoffrey McDermott, Elliott Meer, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Serge Saxonov, John R. Stuelpnagel, Jessica Michele Terry, Tobias Daniel Wheeler, Indira Wu, Solongo Batjargal Ziraldo, Stephane Claude Boutet, Sarah Taylor, Niranjan Srinivas
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Publication number: 20200002764Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.Type: ApplicationFiled: June 17, 2019Publication date: January 2, 2020Inventors: Phillip Belgrader, Zachary Bent, Rajiv Bharadwaj, Vijay Kumar Sreenivasa Gopalan, Josephine Harada, Christopher Hindson, Mohammad Rahimi Lenji, Michael Ybarra Lucero, Geoffrey McDermott, Elliott Meer, Tarjei Sigurd Mikkelsen, Christopher Joachim O'Keeffe, Katherine Pfeiffer, Andrew D. Price, Paul Ryvkin, Serge Saxonov, John R. Stuelpnagel, Jessica Michele Terry, Tobias Daniel Wheeler, Indira Wu, Solongo Batjargal Ziraldo, Stephane Claude Boutet, Sarah Taylor, Niranjan Srinivas
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Publication number: 20190323088Abstract: The present disclosure provides methods, systems, and compositions for parallel processing of nucleic acid samples. Methods and systems of the present disclosure comprise the use of sample-specific barcode sequences, which facilitate the multiplexing of samples, detection of discrete cell populations within a pooled population, and detection of partitions comprising more than one cell.Type: ApplicationFiled: June 12, 2019Publication date: October 24, 2019Inventors: Stephane Claude Boutet, Michael Ybarra Lucero, Elliott Meer, Tarjei Sigurd Mikkelsen, Katherine Pfeiffer, Sarah Taylor, Niranjan Srinivas
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Publication number: 20190177800Abstract: The present disclosure provides methods, systems, and compositions for parallel processing of nucleic acid samples. Methods and systems of the present disclosure comprise the use of sample-specific barcode sequences, which facilitate the multiplexing of samples, detection of discrete cell populations within a pooled population, and detection of partitions comprising more than one cell.Type: ApplicationFiled: August 21, 2018Publication date: June 13, 2019Inventors: Stephane Claude Boutet, Michael Ybarra Lucero, Tarjei Sigurd Mikkelsen, Katherine Pfeiffer
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Patent number: 10222762Abstract: A method of managing an electronic apparatus including a case containing a microcontroller powered with electrical energy by an electrical energy storage and connected to a time base, a mechanism of measuring light intensity, a mechanism of detecting whether the apparatus is being worn, the microcontroller also being connected to a first display and a second display, arranged, in an active operating mode, to be controlled by the electronic control circuit to display at least a first temporal data item at least provided by the time base.Type: GrantFiled: July 3, 2013Date of Patent: March 5, 2019Assignee: ETA SA Manufacture Horlogere SuisseInventors: Fabien Balli, Stephane Claude, Jean Laconte
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Patent number: 9136577Abstract: An orthomode transducer (OMT) operable in a broadband (e.g. >30%), including a frequency above ˜30 GHz, with an isolation better than ?50 dB, cross-polarizations better than ?40 dB, an insertion loss between ?0.1 and ?0.3 dB for both polarizations, and return losses better than ?25 dB can be produced substantially or entirely from CNC machining, comprises a turnstile for coupling a polarization diplexed waveguide with four waveguide paths; and two E-plane Y junctions each for coupling initially oppositely directed pairs of the waveguide paths such that each waveguide path has a same electrical length from the turnstile to the E-plane Y junctions as the waveguide path with which it is paired, such that the OMT is formed in 3-6 blocks, including a single block having a substantially planar mating surface that includes the matching feature, and defines one side of initial segments of the four waveguide paths. Reproducibility of these OMTs has been shown.Type: GrantFiled: June 8, 2010Date of Patent: September 15, 2015Assignee: National Research Council of CanadaInventors: David Dousset, Stephane Claude
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Publication number: 20150168923Abstract: A method of managing an electronic apparatus including a case containing a microcontroller powered with electrical energy by an electrical energy storage and connected to a time base, a mechanism of measuring light intensity, a mechanism of detecting whether the apparatus is being worn, the microcontroller also being connected to a first display and a second display, arranged, in an active operating mode, to be controlled by the electronic control circuit to display at least a first temporal data item at least provided by the time base.Type: ApplicationFiled: July 3, 2013Publication date: June 18, 2015Applicant: ETA SA Manufacture Horlogere SuisseInventors: Fabien Balli, Stéphane Claude, Jean Laconte