Patents by Inventor Stephane Duboux

Stephane Duboux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12644094
    Abstract: Use of a fructose disaccharide or fructooligosaccharide, for increasing protein production in Bifidobacterium longum subsp longum.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: June 2, 2026
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Stephane Duboux, Mireille Golliard, Michiel Kleerebezem
  • Publication number: 20260139219
    Abstract: A Bifidobacterium longum subsp longum produced by a method of growing the Bifidobacterium longum subsp longum in a culture medium, the culture medium containing a fructose disaccharide, FOS or combination thereof. A method for treatment or prevention of inflammatory bowel disease, celiac disease, non-celiac gluten sensitivity, gluten ataxia, dermatitis herpetiformis or wheat allergy in an individual, the method including administering a combination of (i) Bifidobacterium longum subsp longum and (ii) a fructose disaccharide, FOS or a combination thereof to the individual.
    Type: Application
    Filed: January 13, 2026
    Publication date: May 21, 2026
    Inventors: STEPHANE DUBOUX, MIREILLE GOLLIARD, MICHIEL KLEEREBEZEM
  • Patent number: 12496324
    Abstract: The present invention relates to a Bifidobacterium longum probiotic for use to improve fermentability of a plant fibre during gastro-intestinal tract passage in a subject, wherein said plant fibre has an insoluble fraction of between 40 to 80% (w/w).
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: December 16, 2025
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Lisa Marcela Lamothe, Stephane Duboux, Florence Rochat, Rosa Aragao Borner
  • Publication number: 20250295144
    Abstract: The present Invention relates to a beverage composition, preferably a fermented beverage composition, comprising gluconic acid and lactic acid, wherein the concentration ratio of gluconic acid to lactic acid is greater than 1, preferably between 2 to 10.
    Type: Application
    Filed: October 20, 2022
    Publication date: September 25, 2025
    Inventors: STEPHANE DUBOUX, JIYUAN ZHANG, ROSA ARAGAO BORNER, SARAH PRIOUR, JAN PATRICK TAN
  • Publication number: 20250177458
    Abstract: The present invention relates to the use of a Bifidobacterium longum transitional microorganism to metabolise one or more glycan substrates selected from the group recited in any of Tables 1 to 3.
    Type: Application
    Filed: February 24, 2023
    Publication date: June 5, 2025
    Inventors: OMAR DELANNOY-BRUNO, OLGA SAKWINSKA, STEPHANE DUBOUX
  • Publication number: 20240306694
    Abstract: The present invention relates to use of a B. longum transitional microorganism that has a preferential utilization of 3-FL over 2?FL. It also relates to methods and to a composition comprising the B. longum transitional microorganism and uses thereof.
    Type: Application
    Filed: July 8, 2022
    Publication date: September 19, 2024
    Inventors: OLGA SAKWINSKA, STEPHANE DUBOUX, CATHERINE NGOM-BRU, NORBERT SPRENGER
  • Publication number: 20240306690
    Abstract: The invention relates to a composition for infants or young children comprising at least one probiotic bacterial strain, said probiotic bacterial strain being bifidobacteria and a prebiotic mixture of human milk oligosaccharides consisting of 2?-fucosyllactose (2FL), lactodifucotetraose/difucosyllactose (DFL), lacto-N-tetraose (LNT), 6?-sialyllactose (6SL), 3?-sialyllactose (SSL) and optionally 3-fucosyllactose (3FL) that can be useful for (i) preventing and/or treating bacterial infections; (ii) modulating the microbiota; and/or iii) preventing and/or treating allergy in an infant or a young child.
    Type: Application
    Filed: January 21, 2022
    Publication date: September 19, 2024
    Inventors: FLORAC DE BRUYN, KATJA JOHNSON, BILJANA BOGICEVIC, DOMINICK MAES, STEPHANE DUBOUX
  • Publication number: 20240156886
    Abstract: The invention herein relates generally to enhancing the survival and activity of probiotic Lactobacillus strains in mammals. Lactobacillus strain comprising a LacS transporter sequence having a sequence identity of at least 70% to SEQ ID NO: 1, and/or comprising a GH42 B-gal sequence, wherein the Lactobacillus strain is not a Lactobacillus reuteri strain. The invention comprises methods for cultivating and manufacturing probiotic Lactobacillus strains, and products containing such strains. In more detail the GC present invention relates to a composition comprising probiotic Lactobacillus strains, obtained by a step of growing the bacteria in a medium comprising galacto-oligosaccharides (GOS) (“pre-conditioning”), and administering said pre-conditioned bacteria together with GOS in the final product. The inventors have found that such method induces a boost in the beneficial effects of the probiotic bacteria, such as survival in the gastrointestinal tract.
    Type: Application
    Filed: March 11, 2022
    Publication date: May 16, 2024
    Inventors: FLORAC DE BRUYN, BERTRAND BOURQUI, GUENOLEE ELIANE MARIE PRIOULT, STEPHANE DUBOUX
  • Publication number: 20240041948
    Abstract: Compositions contain at least one Staphylococcus carnosus strain, for example at least one of S. carnosus CNCM I-5398 or S. carnosus CNCM I-5400. A unit dosage form of the composition contains a prophylactically or therapeutically effective amount of the at least one Staphylococcus carnosus strain. Methods of making such compositions include adding at least one Staphylococcus carnosus strain to at least one other food component.
    Type: Application
    Filed: December 22, 2021
    Publication date: February 8, 2024
    Inventors: PAUL JOSEPH GIANNASCA, STEPHANE DUBOUX
  • Patent number: 11812755
    Abstract: The present invention relates to flavour generation. In particular the invention relates to a method for flavour generation in a heat-treated food product using a prolidase enzyme. The invention also relates to a heat-treated food product prepared according to the method of the invention.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: November 14, 2023
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Yvette Fleury Rey, Christina Vafeiadi, Stephane Duboux, Catherine Ngom-Bru, Clementine Tastet, Cassandra Mokdad, Christof Gysler, Carl Erik Hansen
  • Publication number: 20230301325
    Abstract: The invention relates to vegan fermented pepperoni or salami analogue products, and methods of making thereof, said methods comprising preparing a pepperoni or salami analogue batter mixture; ripening the mixture; heating the mixture; and drying the mixture to form a vegan fermented pepperoni or salami analogue product.
    Type: Application
    Filed: August 19, 2021
    Publication date: September 28, 2023
    Inventors: CHRISTOPHE JOSEPH ETIENNE SCHMITT, STEPHANE DUBOUX, JOCHEN WEISS, EVA HERZ, DOMINIC OPPEN, KURT HERRMANN, MYRIAM ESTHER LOEFFLER, JOHANNES DREHER
  • Publication number: 20230256036
    Abstract: Use of human milk oligosaccharide LNT, for increasing serpin protein production in Bifidobacterium longum subsp. longum.
    Type: Application
    Filed: June 25, 2021
    Publication date: August 17, 2023
    Inventors: STEPHANE DUBOUX, MICHIEL KLEEREBEZEM, MIREILLE GOLLIARD
  • Publication number: 20230220327
    Abstract: Use of galactose or a galactooligosaccharide, for increasing serpin protein production in Bifidobacterium longum subsp. longum.
    Type: Application
    Filed: June 30, 2020
    Publication date: July 13, 2023
    Inventors: STEPHANE DUBOUX, PETER DUNCAN, MIREILLE GOLLIARD, MICHIEL KLEEREBEZEM
  • Publication number: 20230218695
    Abstract: The present invention relates to a Bifidobacterium longum probiotic for use to improve fermentability of a plant fibre during gastro-intestinal tract passage in a subject, wherein said plant fibre has an insoluble fraction of between 40 to 80% (w/w).
    Type: Application
    Filed: May 18, 2021
    Publication date: July 13, 2023
    Inventors: LISA MARCELA LAMOTHE, STEPHANE DUBOUX, FLORENCE ROCHAT, ROSA ARAGAO BORNER
  • Publication number: 20230210920
    Abstract: Serpin protein producing Bifidobacterium longum subsp. longum and compositions thereof for use in inhibiting gluten digestion. Compositions comprising the serpin protein producing Bifidobacterium longum subsp. longum may be used to mitigate the effects of hidden gluten in individuals following a gluten free diet.
    Type: Application
    Filed: May 11, 2021
    Publication date: July 6, 2023
    Inventors: TIAGO ALVES NUNES, GABRIELA BERGONZELLI DEGONDA, STEPHANE DUBOUX, PETER DUNCAN, CARMINE D'URZO, ELENA VERDU DE BERCIK
  • Publication number: 20230131859
    Abstract: A composition contains at least one probiotic or enzyme selected from the group consisting of (i) a probiotic having ?-glycosidase activity or a ?-glycosidase, (ii) a probiotic having esterase activity or an esterase, (iii) a probiotic having both ?-glycosidase activity and esterase activity or an enzyme having both ?-glycosidase activity and esterase activity, (iv) a first probiotic having ?-glycosidase activity and a second probiotic having esterase activity, (v) a probiotic having ?-glycosidase activity and an esterase, (vi) a ?-glycosidase and a probiotic having esterase activity and (vii) a ?-glycosidase and an esterase. The at least one probiotic can form one or more of oleuropein aglycone, elenolic acid, hydroxytyrosol acetate or hydroxytyrosol from oleuropein. The composition can comprise oleuropein.
    Type: Application
    Filed: December 22, 2022
    Publication date: April 27, 2023
    Inventors: Marie Noelle Horcajada, Stephane Duboux, Laure Poquet
  • Publication number: 20230090660
    Abstract: The present invention relates to the use of a Poaceae and/or a Leguminoseae plant fiber to improve survival of a Bifidobacterium probiotic, wherein said plant fiber has an insoluble fraction of between 40 to 80% (w/w).
    Type: Application
    Filed: May 18, 2021
    Publication date: March 23, 2023
    Inventors: STEPHANE DUBOUX, LISA MARCELA LAMOTHE, ROSA ARAGAO BORNER, FLORENCE ROCHAT
  • Patent number: 11590181
    Abstract: Use of a sugar selected from lactose, fructose and raffinose, for increasing serpin expression in Bifidobacterium longum strain CNCM I-2618.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: February 28, 2023
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Stephane Duboux, Gabriela Bergonzelli Degonda, Annick Mercenier, Muzi Tangyu
  • Patent number: 11504387
    Abstract: A composition contains at least one probiotic or enzyme selected from the group consisting of (i) a probiotic having ?-glycosidase activity or a ?-glycosidase, (ii) a probiotic having esterase activity or an esterase, (iii) a probiotic having both ?-glycosidase activity and esterase activity or an enzyme having both ?-glycosidase activity and esterase activity, (iv) a first probiotic having ?-glycosidase activity and a second probiotic having esterase activity, (v) a probiotic having ?-glycosidase activity and an esterase, (vi) a ?-glycosidase and a probiotic having esterase activity and (vii) a ?-glycosidase and an esterase. The at least one probiotic can form one or more of oleuropein aglycone, elenolic acid, hydroxytyrosol acetate or hydroxytyrosol from oleuropein. The composition can comprise oleuropein.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: November 22, 2022
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Marie Noelle Horcajada, Stephane Duboux, Laure Poquet
  • Patent number: 11484036
    Abstract: The present invention relates to flavour generation. In particular the invention relates to a method for flavour generation in a heat-treated food product using a prolidase enzyme. The invention also relates to a heat-treated food product prepared according to the method of the invention.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: November 1, 2022
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Yvette Fleury Rey, Christina Vafeiadi, Stephane Duboux, Catherine Ngom-Bru, Cassandra Mokdad, Clementine Tastet, Christof Gysler, Carl Erik Hansen