Abstract: The invention relates to compounds of Formula I: or pharmaceutically acceptable solvates thereof, as well as their use in the treatment and/or prevention of diseases or conditions associated with a dysfunction of CFTR channel activity, in particular cystic fibrosis.

Abstract: A method for determining a sensor configuration in a vehicle which includes a plurality of sensors. The method comprises: (i) establishing a preliminary sensor configuration for the vehicle, which sensor configuration includes a first number of real sensors, each of which outputting a real sensor signal, (ii) determining whether at least one of the real sensors can be replaced by a virtual sensor, and (iii) changing the preliminary sensor configuration into a final sensor configuration which includes a second number of real sensors and at least one virtual sensor which has been determined to replace at least one of the real sensors, wherein the second number is smaller than the first number.

Abstract: The present invention concerns compounds belonging to the family of fluorinated pyridazin-3-ones, for the use thereof in the treatment of broncho-pulmonary conditions. In compounds having a formula, or a pharmaceutically acceptable salt of the compound, the formula includes R1 representing H, an alkyl, an aryl or a heteroaryl; either E2 and E3 representing, separately from each other, H, an alkyl, an aryl or a heteroaryl, or R2 and R3 being bridged within a same cycle or via several cycles; and F representing CF3, (CF2)nCF3 or CF2H, with n representing an integer of between 1 and 7.

Abstract: This invention utilizes a co-extrusion or co-drawing process to directly bond a tubular target to an inner backing tube. The co-extrusion or co-drawing process reduces the inner and outer diameters of the outer tubular target to cause portions of the target to protrude and at least partially fill into grooves along the inner backing tube. The filling causes the target to interlock to the backing plate.

Abstract: The implantable monopolar electrode assembly includes a base support structure including a layer made of a nickel titanium alloy having a temperature memory. The method is directed to electro-stimulation of muscles and to a method of implanting a monopolar electrode assembly. The method includes the steps of: first performing an endoscopic approach to the nerves and then selective electro stimulation by performing a neurolysis on nerve trunks until a desired target nerve fascicle and associated muscle is located, followed by insertion of the monopolar electrode assembly adjacent the target nerve fascicle for subsequent connection to a neurposthesis system.