Patents by Inventor Stephane Gingras

Stephane Gingras has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF
    Publication number: 20230357221
    Abstract: Heterocyclic compounds of Formula I: and pharmaceutically acceptable salt thereof are disclosed. The use of such heterocyclic compounds and pharmaceutically acceptable salt thereof for the treatment of cancers, and more particularly cancers sensitive to mitochondrial activity inhibition and increased reactive oxygen species (ROS) levels, is also disclosed.
    Type: Application
    Filed: June 28, 2023
    Publication date: November 9, 2023
    Inventors: Yves GAREAU, Stéphane GINGRAS, Yves CHANTIGNY, Gaoqiang YANG, Guy SAUVAGEAU, Irène BACCELLI, Anne MARINIER
  • Heterocyclic mitochondrial activity inhibitors and uses thereof
    Patent number: 11760754
    Abstract: Heterocyclic compounds of Formula (I) and pharmaceutically acceptable salt thereof are disclosed. The use of such heterocyclic compounds and pharmaceutically acceptable salt thereof for the treatment of cancers, and more particularly cancers sensitive to mitochondrial activity inhibition and increased reactive oxygen species (ROS) levels, is also disclosed.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: September 19, 2023
    Assignee: UNIVERSITÉ DE MONTRÉAL
    Inventors: Yves Gareau, Stéphane Gingras, Yves Chantigny, Gaoqiang Yang, Guy Sauvageau, Irène Baccelli, Anne Marinier
  • HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF
    Publication number: 20210387980
    Abstract: Heterocyclic compounds of Formula (I) and pharmaceutically acceptable salt thereof are disclosed. The use of such heterocyclic compounds and pharmaceutically acceptable salt thereof for the treatment of cancers, and more particularly cancers sensitive to mitochondrial activity inhibition and increased reactive oxygen species (ROS) levels, is also disclosed.
    Type: Application
    Filed: November 2, 2018
    Publication date: December 16, 2021
    Inventors: Yves Gareau, Stéphane Gingras, Yves Chantigny, Gaoqiang Yang, Guy Sauvageau, Irène Baccelli, Anne Marinier
  • Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells
    Patent number: 10647718
    Abstract: Compounds of general formula or salts or prodrugs thereof, are provided and described herein. The compounds are useful to expand hematopoietic stem cell and/or hematopoietic progenitor cell populations. Particularly, the hematopoietic cells are human cells. The compounds are also useful in the medical treatment of hematopoietic disorder/malignancy, an autoimmune disease and/or an inherited immune-deficient disease in a subject.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: May 12, 2020
    Assignee: UNIVERSITÉDE MONTRÉAL
    Inventors: Guy Sauvageau, Yves Gareau, Stéphane Gingras
  • Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells
    Patent number: 10336747
    Abstract: Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations. The compounds are also useful in the medical treatment of diseases that involve hematopoietic stem cells.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: July 2, 2019
    Assignee: UNIVERSITÉ DE MONTRÉAL
    Inventors: Guy Sauvageau, Yves Gareau, Rejean Ruel, Stephane Gingras, Iman Fares
  • PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS
    Publication number: 20170334904
    Abstract: Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations. The compounds are also useful in the medical treatment of diseases that involve hematopoietic stem cells.
    Type: Application
    Filed: December 2, 2016
    Publication date: November 23, 2017
    Applicant: UNIVERSITÉ DE MONTRÉAL
    Inventors: Guy SAUVAGEAU, Yves GAREAU, Rejean RUEL, Stephane GINGRAS, Iman FARES
  • COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS
    Publication number: 20170037047
    Abstract: Compounds of general formula or salts or prodrugs thereof, are provided and described herein. The compounds are useful to expand hematopoietic stem cell and/or hematopoietic progenitor cell populations. Particularly, the hematopoietic cells are human cells. The compounds are also useful in the medical treatment of hematopoietic disorder/malignancy, an autoimmune disease and/or an inherited immune-deficient disease in a subject.
    Type: Application
    Filed: April 21, 2015
    Publication date: February 9, 2017
    Inventors: Guy SAUVAGEAU, Yves GAREAU, Stéphane GINGRAS
  • Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
    Patent number: 9493456
    Abstract: Disclosed herein is a compound of Formula I: wherein X, R1, R2, and R3 are as defined herein, or a pharmaceutically acceptable salt thereof to allow the drug to penetrate the cell membrane; or a prodrug, or the compound is labeled with a detectable label or an affinity tag thereof. Also disclosed is a pharmaceutical composition, a method of treating a disorder mediated by melanocortin-4 receptors, and a method of treating obesity using the compounds described.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: November 15, 2016
    Assignee: UNIVERSITE DE MONTREAL
    Inventors: Michel Bouvier, Anne Marinier, Réjean Ruel, Patricia René, Yves Chantigny, Philippe Dagneau, Stéphane Gingras
  • Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells
    Patent number: 9409906
    Abstract: Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations. The compounds are also useful in the medical treatment of diseases that involve hematopoietic stem cells.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: August 9, 2016
    Assignee: UNIVERSITE DE MONTREAL
    Inventors: Guy Sauvageau, Yves Gareau, Réjean Ruel, Stéphane Gingras, Iman Fares
  • PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS
    Publication number: 20160222017
    Abstract: Pyrimido[4,5-b]indole derivatives are provided. These compounds are useful to expand hematopoietic stem cell populations, particularly, human hematopoietic stem cell populations. The compounds are also useful in the medical treatment of diseases that involve hematopoietic stem cells.
    Type: Application
    Filed: February 18, 2016
    Publication date: August 4, 2016
    Applicant: UNIVERSITÉ DE MONTRÉAL
    Inventors: Guy SAUVAGEAU, Yves GAREAU, Rejean RUEL, Stéphane GINGRAS, Iman FARES
  • PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS
    Publication number: 20150197520
    Abstract: Disclosed herein is a compound of Formula I: wherein X, R1, R2, and R3 are as defined herein, or a pharmaceutically acceptable salt thereof to allow the drug to penetrate the cell membrane; or a prodrug, or the compound is labeled with a detectable label or an affinity tag thereof. Also disclosed is a pharmaceutical composition, a method of treating a disorder mediated by melanocortin-4 receptors, and a method of treating obesity using the compounds described.
    Type: Application
    Filed: March 26, 2015
    Publication date: July 16, 2015
    Inventors: Michel Bouvier, Anne Marinier, Réjean Ruel, Patricia René, Yves Chantigny, Philippe Dagneau, Stéphane Gingras
  • Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
    Patent number: 9018395
    Abstract: Disclosed herein is a compound of Formula I: wherein X, R1, R2, and R3 are as defend herein, or a pharmaceutically acceptable salt thereof to allow the drug to penetrate the cell membrane; or a prodrug, or the compound is labeled with a detectable label or an affinity tag thereof. Also disclosed is a pharmaceutical composition, a method of treating a disorder mediated by melanocortin-4 receptors, and a method of treating obesity using the compounds described.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: April 28, 2015
    Assignee: Université de Montréal
    Inventors: Michel Bouvier, Anne Marinier, Réjean Ruel, Patricia René, Yves Chantigny, Philippe Dagneau, Stéphane Gingras
  • PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS
    Publication number: 20140057894
    Abstract: Disclosed herein is a compound of Formula I: wherein X, R1, R2, and R3 are as defend herein, or a pharmaceutically acceptable salt thereof to allow the drug to penetrate the cell membrane; or a prodrug, or the compound is labeled with a detectable label or an affinity tag thereof. Also disclosed is a pharmaceutical composition, a method of treating a disorder mediated by melanocortin-4 receptors, and a method of treating obesity using the compounds described.
    Type: Application
    Filed: January 26, 2012
    Publication date: February 27, 2014
    Applicant: Universite De Montreal
    Inventors: Michel Bouvier, Anne Marinier, Rejean Ruel, Patricia René, Yves Chantigny, Philippe Dagneau, Stéphane Gingras
  • Processes for the preparation of antiviral 7-azaindole derivatives
    Patent number: 6884889
    Abstract: Provided are processes and synthetic intermediates useful for the preparation of azaindole piperazine diamide derivatives of the formula These azaindole piperazine diamide derivatives, among other things, are useful as therapeutic agents for the treatment of HIV and AIDS.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: April 26, 2005
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Nachimuthu Soundararajan, Serge Benoit, Stephane Gingras
  • Processes for the preparation of antiviral 7-azaindole derivatives
    Publication number: 20040044025
    Abstract: Provided are processes and synthetic intermediates useful for the preparation of azaindole piperazine diamide derivatives of the formula 1
    Type: Application
    Filed: March 24, 2003
    Publication date: March 4, 2004
    Inventors: Nachimuthu Soundararajan, Serge Benoit, Stephane Gingras