Patents by Inventor Stephane Laporte

Stephane Laporte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prostaglandin-F2 alpha receptor modulators and uses thereof
    Patent number: 8802818
    Abstract: Prostaglandin-F2 alpha (PGF2?) receptor (FP) modulators of formula I, as well as the use of PGF2? receptor modulators for the treatment of conditions associated with FP activity such as preterm labor and colorectal cancer, are disclosed.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: August 12, 2014
    Inventors: William D. Lubell, Sylvain Chemtob, Terence E. Hebert, Audrey Claing, Stephane Laporte, Carine B. Bourguet, Eugenie Goupil, Xin Hou, Danae Tassy
  • Phosphoinositide 3-kinase mediated inhibition of GPCRs
    Publication number: 20060026702
    Abstract: The present invention relates to compounds that alter GPCR internalization and new methods for their identification. Compounds of this invention include modified phosphoinositide 3-kinase (PI3K), modified HEAT domain, modified ?-adrenergic receptor kinase 1 (?ARK1), as well as other peptides or small molecules that alter GPCR internalization. The present invention also includes the use of such compounds to treat GPCR-related diseases, such as cardiovascular disease, heart failure, asthma, nephrogenic diabetes insipidus, or hypertension.
    Type: Application
    Filed: July 30, 2004
    Publication date: February 2, 2006
    Applicant: DUKE UNIVERSITY
    Inventors: Howard Rockman, Sathyamangla Naga Prasad, Stephane Laporte, Larry Barak, Marc Caron
  • Modified G-protein coupled receptors
    Publication number: 20050106623
    Abstract: The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have carboxyl terminal tails comprising one or more sites of phosphorylation, preferably one or more clusters of phosphorylation sites. The modified GPCRs of the present invention may comprise a retained portion of a carboxyl-terminus region from a first GPCR fused to a polypeptide, wherein the polypeptide comprises the one or more clusters of phosphorylation. The present invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRS.
    Type: Application
    Filed: December 30, 2004
    Publication date: May 19, 2005
    Inventors: Robert Oakley, Lawrence Barak, Stephane Laporte, Marc Caron