Abstract: The invention concerns a preoperative probe (2) for guiding an ablation tool, comprising a sensing head (21), said sensing head including: at least one optic fiber (2121, 2123) for receiving and guiding a signal emitted, by radioactive tracers and/or fluorescent molecules in a tissue zone, to an analyzing equipment (32), fixing means (2112) for mounting the head (21) on the ablation tool (1), such that the ablation tool is capable of extracting a portion of tissue in the tissue zone emitting the signal.

Abstract: A peroperative probe for guiding a manual excision tool. The probe includes a detection head, an optical fiber for the reception and guidance of a signal emitted by radioactive tracers and fluorescent molecules in a tissue area, a photo-detector for converting the emitted signal into an electrical signal, a transmitter for transmitting information carried by the electrical signal to an analysis equipment, and a fastener for attaching the probe onto the manual excision tool, so that the excision tool can be used to remove a portion of tissue from the tissue area emitting the signal.

Abstract: A preoperative probe for guiding a manual excision tool. The probe includes a detection head, an optical fibre for the reception and guidance of a signal emitted by radioactive tracers and fluorescent molecules in a tissue area, a photo-detector for converting the emitted signal into an electrical signal, a transmitter for transmitting information carried by the electrical signal to an analysis equipment, and a fastener for attaching the probe onto the manual excision tool, so that the excision tool can be used to remove a portion of tissue from the tissue area emitting the signal.

Abstract: Provided is an improved treatment for Parkinson's Disease where the efficacy of L-Dopa treatment is increased by including gene therapy in the treatment regimen. The combination therapy results in long-term improvements in response to L-Dopa and diminished side effects caused by L-Dopa.

Abstract: The present invention provides methods for: (i) treating and/or preventing Parkinson's disease in a subject without causing cognitive impairment by using dopamine replacement gene therapy to maintain or restore constant physiological dopaminergic tone in both the dorsal and ventral striatum of the subject; (ii) normalising neuronal electrical activity in basal ganglia and/or subthalamic nucleus in a Parkinson's disease subject; and (iii) treating and/or preventing dyskinesias associated with oral L-dopa administration in a Parkinson's disease subject by administration of a vector system for dopamine replacement gene therapy to the subject.

Abstract: The invention concerns a preoperative probe (2) for guiding an ablation tool, comprising a sensing head (21), said sensing head including: at least one optic fiber (2121, 2123) for receiving and guiding a signal emitted, by radioactive tracers and/or fluorescent molecules in a tissue zone, to an analyzing equipment (32), fixing means (2112) for mounting the head (21) on the ablation tool (1), such that the ablation tool is capable of extracting a portion of tissue in the tissue zone emitting the signal.