Abstract: A calculation module for determining a probability model of a parameter of a first reference posture of a subject, the probability model being intended to determine at least a production parameter of an optical element suitable for the subject, the calculation module being configured: to determine at least one value of a parameter of a second reference posture, during an occurrence of the second reference posture, and to determine the probability model of a parameter of a first reference posture based on the at least one value of the parameter of the second reference posture.

Abstract: The present invention provides a method of treating Philadelphia positive (Ph+) leukemia, such as Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) or chronic myeloid leukemia (CML), in a human patient population comprising the steps of (a) administering a predetermined fixed therapeutically effective amount of an Bcr-Abl tyrosine kinase inhibitor, such as Imatinib, or a pharmaceutically acceptable salt thereof to human patients suffering from a Ph+ leukemia, (b) collecting at least one blood sample from said patients, (c) determining the plasma trough level (Cmin) of the Bcr-Abl tyrosine kinase inhibitor or of a metabolite thereof as well as the MMR rates, (d) assessing a discrimination potential of trough plasma concentrations for MMR and identifying a Cmin threshold for optimal sensitivity and specificity and (e) adjusting the dose of the inhibitor of the Bcr-Abl tyrosine kinase or a pharmaceutically acceptable salt thereof applied to the individual patients from said patient populat

Abstract: The invention relates to a shock-absorber for aircraft landing gear, the shock-absorber having two elements mounted to slide telescopically one in the other and defining an internal volume that is filled with hydraulic fluid and with gas, the internal volume being separated into at least two chambers by a separation including at least one throttling orifice through which the hydraulic fluid passes from one chamber to the other while the shock-absorber is being compressed. According to the invention, the separation includes at least one degassing orifice to enable gas to be transferred from one chamber to the other when the landing gear is in the deployed position, the degassing orifice being offset vertically relative to the throttling orifice so as to be located above it when the landing gear is in the deployed position.

Abstract: The invention relates to a shock-absorber for aircraft landing gear, the shock-absorber having two elements (1, 2) mounted to slide telescopically one in the other and defining an internal volume that is filled with hydraulic fluid and with gas, the internal volume being separated into at least two chambers (7, 8) by a separation (5) including at least one throttling orifice (10) through which the hydraulic fluid passes from one chamber to the other while the shock-absorber is being compressed. According to the invention, the separation includes at least one degassing orifice to enable gas to be transferred from one chamber to the other when the landing gear is in the deployed position, the degassing orifice being offset vertically relative to the throttling orifice so as to be located above it when the landing gear is in the deployed position.

Abstract: The present invention provides a method of treating Philadelphia positive (Ph+) leukemia, such as Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) or chronic myeloid leukemia (CML), in a human patient population comprising the steps of (a) administering a predetermined fixed amount of a Bcr-Abl tyrosine kinase inhibitor, such as Imatinib, or a pharmaceutically acceptable salt thereof to human patients suffering from a Ph+ leukemia, (b) collecting at least one blood sample from said patients, (c) determining the plasma trough level (Cmin) of the Bcr-Abl tyrosine kinase inhibitor or of a metabolite thereof as well as the MMR rates, (d) assessing a discrimination potential of trough plasma concentrations for MMR and identifying a Cmin threshold for optimal sensitivity and specificity and (e) adjusting the dose of the inhibitor of the Bcr-Abl tyrosine kinase or a pharmaceutically acceptable salt thereof applied to the individual patients from said patient population and, optionally, future

Abstract: A pocket computer comprising a plurality of programs and data, loading of and access to said programs and data being managed by an operating system. The pocket computer comprises means for selecting one of at least two predefined contexts of use and a context database that comprises a list of associated programs and data for each predefined context of use. In response to selection of a context of use, the operating system interrogates the context database in order to activate from the plurality of programs and data only programs and data associated with said context in the context base.

Abstract: A pocket computer comprising a plurality of programs and data, loading of and access to said programs and data being managed by an operating system. The pocket computer comprises means for selecting one of at least two predefined contexts of use and a context database that comprises a list of associated programs and data for each predefined context of use. In response to selection of a context of use, the operating system interrogates the context database in order to activate from the plurality of programs and data only programs and data associated with said context in the context base.