Patents by Inventor Stephanie A. Smith

Stephanie A. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12350399
    Abstract: A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.
    Type: Grant
    Filed: May 31, 2023
    Date of Patent: July 8, 2025
    Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois
    Inventors: Damien Kudela, Galen D. Stucky, Anna May-Masnou, Gary Bernard Braun, James H. Morrissey, Stephanie A. Smith
  • Publication number: 20240398853
    Abstract: Provided herein are compositions and methods to prevent and to treat thrombosis, to reverse the anticoagulant action of heparin, and to prevent and to treat the thrombotic and antifibrinolytic effect of nucleic acids. In particular, provided herein are compositions, methods, kits, systems and uses for switchable charge state multivalent biocompatible polycations for polyanion inhibition in blood.
    Type: Application
    Filed: September 21, 2022
    Publication date: December 5, 2024
    Inventors: James H. Morrissey, Jayachandran N. Kizhakkedathu, Chanel C. La, Charles A. Hayes, Stephanie A. Smith, Sreeparna Vappala
  • Publication number: 20240157022
    Abstract: A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.
    Type: Application
    Filed: May 31, 2023
    Publication date: May 16, 2024
    Inventors: Damien Kudela, Galen D. Stucky, Anna May-Masnou, Gary Bernard Braun, James H. Morrissey, Stephanie A. Smith
  • Patent number: 11707550
    Abstract: A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: July 25, 2023
    Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois
    Inventors: Damien Kudela, Galen D. Stucky, Anna May-Masnou, Gary Bernard Braun, James H. Morrissey, Stephanie A. Smith
  • Patent number: 11519917
    Abstract: Provided herein are compositions and methods for quantifying polyphosphates. In particular, provided herein are solution and substrate based assays for quantifying polyphosphates in complex samples.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: December 6, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: James H. Morrissey, Stephanie A. Smith, Catherine J. Baker, Rachel Hemp, Richard J. Travers
  • Publication number: 20210213159
    Abstract: A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.
    Type: Application
    Filed: November 16, 2020
    Publication date: July 15, 2021
    Inventors: Damien Kudela, Galen D. Stucky, Anna May-Masnou, Gary Bernard Braun, James H. Morrissey, Stephanie A. Smith
  • Patent number: 10842908
    Abstract: A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: November 24, 2020
    Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois
    Inventors: Damien Kudela, Galen D Stucky, Anna May-Masnou, Gary Bernard Braun, James H Morrissey, Stephanie A Smith
  • Publication number: 20200150126
    Abstract: Provided herein are compositions and methods for quantifying polyphosphates. In particular, provided herein are solution and substrate based assays for quantifying polyphosphates in complex samples.
    Type: Application
    Filed: April 13, 2018
    Publication date: May 14, 2020
    Inventors: James H. Morrissey, Stephanie A. Smith, Catherine J. Baker, Rachel Hemp, Richard J. Travers
  • Publication number: 20200023096
    Abstract: A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.
    Type: Application
    Filed: April 22, 2019
    Publication date: January 23, 2020
    Inventors: Damien Kudela, Galen D. Stucky, Anna May-Masnou, Gary Bernard Braun, James H. Morrissey, Stephanie A. Smith
  • Patent number: 10293077
    Abstract: A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: May 21, 2019
    Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois
    Inventors: Damien Kudela, Galen D. Stucky, Anna May-Masnou, Gary Bernard Braun, James H. Morrissey, Stephanie A. Smith
  • Patent number: 9597375
    Abstract: Methods for stopping or slowing bleeding from a wound are provided; these methods include the step of administering a composition comprising a polyphosphate (polyP) to blood from the wound at the site of the wound. Also provided are methods for slowing fibrinolysis and for blocking the action of Tissue Factor Pathway Inhibitor (TFPI) with the use of polyP.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: March 21, 2017
    Assignee: The Board of Trustees of the University of Illinios
    Inventors: James H. Morrissey, Stephanie A. Smith, Roberto Docampo, Nicola J. Mutch
  • Publication number: 20170054176
    Abstract: A sodium-ion battery includes a cathode comprising sodium; and an anode composition comprising a material having the formula: AaBbCcDdO, where A is an alkali metal, alkaline earth metal, or a combination thereof, where B is titanium, C is vanadium, D is one or more transition metal element other than titanium or vanadium, a+b+c+d?1, a?0, b+c>0, b?0, c?0, d>0, and where the material comprises a ilmenite structure, triclinic VFeO4 structure, cubic Ca5Co4(VO4)6 structure, dichromate structure, orthorhombic ?-CoV3O8 structure, brannerite structure, thortveitite structure, orthorhombic ?-CrPO4 structure, or the pseudo rutile structure.
    Type: Application
    Filed: April 29, 2015
    Publication date: February 23, 2017
    Inventors: Mark N. Obrovac, Zachary L. Brown, Ryan I. Fielden, Stephanie A. Smith
  • Publication number: 20160213809
    Abstract: A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.
    Type: Application
    Filed: October 14, 2015
    Publication date: July 28, 2016
    Inventors: Damien Kudela, Galen D. Stucky, Anna May-Masnou, Gary Bernard Braun, James H. Morrissey, Stephanie A. Smith
  • Patent number: 9241958
    Abstract: A method for treating a coagulation deficient patient comprises administering an amount of polyP to the patient sufficient to reduce the PT Test value or Dilute PT Test value of the plasma of the patient.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: January 26, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Stephanie A. Smith, James H. Morrissey
  • Patent number: 9186417
    Abstract: A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: November 17, 2015
    Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois
    Inventors: Damien Kudela, Galen D. Stucky, Anna May-Masnou, Gary Bernard Braun, James H. Morrissey, Stephanie A. Smith
  • Publication number: 20140255336
    Abstract: A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 11, 2014
    Inventors: Damien Kudela, Galen D. Stucky, Anna May-Masnou, Gary Bernard Braun, James H. Morrissey, Stephanie A. Smith
  • Patent number: 8821861
    Abstract: A fibrin sealant, comprises (a) thrombin, (b) fibrinogen, (c) polyP, and (d) calcium. The thrombin and the fibrinogen are separated prior to application.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: September 2, 2014
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Stephanie A. Smith, James H. Morrissey
  • Publication number: 20140186462
    Abstract: A method for treating a coagulation deficient patient comprises administering an amount of polyP to the patient sufficient to reduce the PT Test value or Dilute PT Test value of the plasma of the patient.
    Type: Application
    Filed: January 30, 2014
    Publication date: July 3, 2014
    Inventors: Stephanie A. SMITH, James H. MORRISSEY
  • Publication number: 20100297257
    Abstract: A method for treating a coagulation deficient patient comprises administering an amount of polyP to the patient sufficient to reduce the PT Test value or Dilute PT Test value of the plasma of the patient.
    Type: Application
    Filed: November 3, 2008
    Publication date: November 25, 2010
    Applicant: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS)
    Inventors: Stephanie A. Smith, James H. Morrissey
  • Publication number: 20100284998
    Abstract: A fibrin sealant, comprises (a) thrombin, (b) fibrinogen, (c) polyP, and (d) calcium. The thrombin and the fibrinogen are separated prior to application.
    Type: Application
    Filed: October 2, 2008
    Publication date: November 11, 2010
    Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Stephanie A. Smith, James H. Morrissey