Patents by Inventor Stephanie Chu

Stephanie Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hybrid suppressor tRNA for vertebrate cells
    Patent number: 9868972
    Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O-tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: January 16, 2018
    Assignee: Ambrx,Inc.
    Inventors: Feng Tian, Thea Norman, Stephanie Chu
  • Modified animal erythropoietin polypeptides and their uses
    Patent number: 9644014
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provided.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: May 9, 2017
    Assignees: Ambrx, Inc., Eli Lilly and Company
    Inventors: Feng Tian, Anna-Maria A. Hays Putnam, Frank Song, Stephanie Chu, Joseph Sheffer, Richard S. Barnett, Marc Siladi, Kyle Atkinson, Darin Lee, Peter C. Canning
  • Multi-directional wiring routing device and method of operating the same
    Patent number: 9620892
    Abstract: A multi-directional wiring routing device and method for operating thereof removably or permanently connects to a female housing of an electrical connector system. The multi-directional wiring routing device secures thereon and directs the wiring, at any desired routing direction, the wiring extending from the female housing. The wiring routing device includes an end portion having a substantially diamond-shape configuration portion, which is fitted into a corresponding substantially diamond-shape opening of the female housing of the electrical connector system. While maintaining the optimal performance of the electrical connector system, a bundle of wiring thereof can be neatly secured and efficiently routed towards any desired direction with the use of the multi-directional wiring routing device.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: April 11, 2017
    Assignee: J.S.T. CORPORATION
    Inventors: Vern Shen Ng, Tommy Chin Yaw Tan, Stella Shu Juan Peh, Stephanie Chu Ping Neo, Franklin Holub
  • Hybrid Suppressor tRNA for Vertebrate Cells
    Publication number: 20170096696
    Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O-tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
    Type: Application
    Filed: August 6, 2015
    Publication date: April 6, 2017
    Applicant: AMBRX, INC.
    Inventors: Feng TIAN, Thea NORMAN, Stephanie CHU
  • MODIFIED ANIMAL ERYTHROPOIETIN POLYPEPTIDES AND THEIR USES
    Publication number: 20160024166
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provided.
    Type: Application
    Filed: September 15, 2015
    Publication date: January 28, 2016
    Inventors: Feng TIAN, Anna-Maria A. HAYS PUTNAM, Frank SONG, Stephanie CHU, Joseph SHEFFER, Richard S. BARNETT, Marc SILADI, Kyle ATKINSON, Darin LEE, Peter C. CANNING
  • Modified animal erythropoietin polypeptides and their uses
    Patent number: 9156899
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provided.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: October 13, 2015
    Assignees: ELI LILLY AND COMPANY, AMBRX, INC.
    Inventors: Feng Tian, Anna-Maria A. Hays Putnam, Frank Song, Stephanie Chu, Joseph Sheffer, Richard S. Barnett, Marc Siladi, Kyle Atkinson, Darin Lee, Peter C. Canning
  • Hybrid suppressor tRNA for vertebrate cells
    Patent number: 9133495
    Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O-tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: September 15, 2015
    Assignee: Ambrx, Inc.
    Inventors: Feng Tian, Thea Norman, Stephanie Chu
  • Modified human plasma polypeptide or Fc scaffolds and their uses
    Patent number: 9074010
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: July 7, 2015
    Assignee: Ambrx, Inc.
    Inventors: Joseph Sheffer, Thea Norman, Richard D. Dimarchi, Anna-Maria A. Hays Putnam, Feng Tian, Stephanie Chu, Denise Krawitz, Ho Sung Cho
  • MULTI-DIRECTIONAL WIRING ROUTING DEVICE AND METHOD OF OPERATING THE SAME
    Publication number: 20150162693
    Abstract: A multi-directional wiring routing device and method for operating thereof removably or permanently connects to a female housing of an electrical connector system. The multi-directional wiring routing device secures thereon and directs the wiring, at any desired routing direction, the wiring extending from the female housing. The wiring routing device includes an end portion having a substantially diamond-shape configuration portion, which is fitted into a corresponding substantially diamond-shape opening of the female housing of the electrical connector system. While maintaining the optimal performance of the electrical connector system, a bundle of wiring thereof can be neatly secured and efficiently routed towards any desired direction with the use of the multi-directional wiring routing device.
    Type: Application
    Filed: December 6, 2013
    Publication date: June 11, 2015
    Applicant: J.S.T. CORPORATION
    Inventors: Vern Shen NG, Tommy Chin Yaw TAN, Stella Shu Juan PEH, Stephanie Chu Ping NEO, Franklin HOLUB
  • Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses
    Publication number: 20140296487
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Application
    Filed: November 22, 2013
    Publication date: October 2, 2014
    Applicant: AMBRX, INC.
    Inventors: Joseph SHEFFER, Thea NORMAN, Richard D. DIMARCHI, Anna-Maria A. HAYS PUTNAM, Feng TIAN, Stephanie CHU, Denise KRAWITZ, Ho Sung CHO
  • Suppressor tRNA Transcription in Vertebrate Cells
    Publication number: 20140045259
    Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.
    Type: Application
    Filed: March 27, 2013
    Publication date: February 13, 2014
    Applicant: AMBRX, INC.
    Inventors: Feng TIAN, Thea NORMAN, Stephanie CHU
  • MODIFIED ANIMAL ERYTHROPOIETIN POLYPEPTIDES AND THEIR USES
    Publication number: 20140011740
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provided.
    Type: Application
    Filed: September 20, 2013
    Publication date: January 9, 2014
    Applicants: Eli Lilly Company, Ambrx, Inc.
    Inventors: Feng TIAN, Anna-Maria A. HAYS PUTNAM, Frank SONG, Stephanie CHU, Joseph SHEFFER, Richard S. BARNETT, Marc SILADI, Kyle ATKINSON, Darin LEE, Peter C. CANNING
  • Modified human plasma polypeptide or Fc scaffolds and their uses
    Patent number: 8618257
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: December 31, 2013
    Assignee: Ambrx, Inc.
    Inventors: Joseph Sheffer, Thea Norman, Richard D. Dimarchi, Anna-Maria A. Hays Putnam, Feng Tian, Stephanie Chu, Denise Krawitz, Ho Sung Cho
  • Modified animal erythropoietin polypeptides and their uses
    Patent number: 8569233
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provide.
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: October 29, 2013
    Assignees: Eli Lilly and Company, AMBRX, Inc.
    Inventors: Feng Tian, Anna-Maria A. Hays Putnam, Frank Song, Stephanie Chu, Joseph Sheffer, Richard S. Barnett, Marc Siladi, Kyle Atkinson, Darin Lee, Peter C. Canning
  • Suppressor tRNA transcription in vertebrate cells
    Patent number: 8420792
    Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: April 16, 2013
    Assignee: Ambrx, Inc.
    Inventors: Feng Tian, Thea Norman, Stephanie Chu
  • MODIFIED ANIMAL ERYTHROPOIETIN POLYPEPTIDES AND THEIR USES
    Publication number: 20130017995
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provide.
    Type: Application
    Filed: July 24, 2012
    Publication date: January 17, 2013
    Applicants: ELI LILLY AND COMPANY, AMBRX, INC.
    Inventors: Feng TIAN, Anna-Maria A. HAYS PUTNAM, Frank SONG, Stephanie CHU, Joseph SHEFFER, Richard S. BARNETT, Marc E. SILADI, Kyle ATKINSON, Darin LEE, Peter C. CANNING
  • Modified animal erythropoietin polypeptides and their uses
    Patent number: 8278418
    Abstract: Modified animal erythropoietin polypeptides and uses thereof are provide.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: October 2, 2012
    Assignee: Ambrx, Inc.
    Inventors: Feng Tian, Anna-Maria A. Hays Putnam, Frank Song, Stephanie Chu, Joseph Sheffer, Richard S. Barnett, Marc E. Siladi, Kyle Atkinson, Darin Lee, Peter C. Canning
  • Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses
    Publication number: 20120190827
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Application
    Filed: August 11, 2011
    Publication date: July 26, 2012
    Applicant: AMBRX, INC.
    Inventors: Joseph SHEFFER, Thea NORMAN, Richard D. DIMARCHI, Anna-Maria A. HAYS PUTNAM, Feng TIAN, Stephanie CHU, Denise KRAWITZ, Ho Sung CHO
  • Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses
    Publication number: 20120041180
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Application
    Filed: July 18, 2011
    Publication date: February 16, 2012
    Applicant: AMBRX, INC.
    Inventors: Joseph SHEFFER, Thea NORMAN, Richard D. DIMARCHI, Anna-Maria A. HAYS PUTNAM, Feng TIAN, Stephanie CHU, Denise KRAWITZ, Ho Sung CHO
  • Modified human plasma polypeptide or Fc scaffolds and their uses
    Patent number: 8053560
    Abstract: Modified human plasma polypeptides or Fc and uses thereof are provided.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: November 8, 2011
    Assignee: Ambrx, Inc.
    Inventors: Joseph Sheffer, Thea Norman, Richard D. Dimarchi, Anna-Maria A. Hays Putnam, Feng Tian, Stephanie Chu, Denise Krawitz, Ho Sung Cho