Abstract: A method of establishing a therapeutic window of wound fluid nitric oxide (WFNO) in the wound of a mammal, the method including: obtaining a wound fluid sample from a mammal; analyzing the WFNO level; determining whether the WFNO is at or below a lower threshold level, or is at or above an upper threshold level; wherein the lower threshold level and upper threshold level define the therapeutic window of WFNO; and treating the mammal with a substance that alters the WFNO level such that the therapeutic window of WFNO in the wound is established.

Abstract: The present disclosure provides devices and rapid methods to acquire a wound sample to detect and measure NOx, and optionally, one or more other analytes that are indicative of the status of a wound.

Abstract: The present disclosure provides devices and rapid methods to acquire a wound sample to detect the presence of NOx and, optionally, one or more other analytes that are indicative of the status of a wound.

Abstract: Nitric oxide releasing compositions, which comprise nanoparticles having an exterior surface comprising solid amorphous silica, the exterior surface having nitrosothiol-containing groups attached thereto, the nanoparticles being dispersible in an aqueous system, devices including the compositions, and methods of making and using the compositions and devices are disclosed.

Abstract: A method of analyzing wound samples is provided. The analysis typically involves the use of mass spectrometry.

Abstract: The invention comprises compositions and methods useful for encapsulation and controlled release of guest molecules, such as drugs. Compositions of the present invention comprise a matrix comprising molecules that are non-covalently crosslinked by multi-valent cations, wherein the molecules that are non-covalently crosslinked are non-polymeric, have more than one carboxy functional group, and have at least partial aromatic or heteroaromatic character The compositions are characterized in that a guest molecule may be encapsulated within the matrix and subsequently released.

Abstract: A preformed object for delivering an active agent for a subject, the preformed object including crosslinked protein, and methods of making and using.

Abstract: Methods for performing immunological assays are provided. The methods allow performing immunological assays with increased sensitivity, increased specificity, or both. Kits for performing immunological assays having increased sensitivity, increased specificity, or both, are also provided.

Abstract: A preformed object for delivering an active agent to a subject, the preformed object including crosslinked protein, and methods of making and using.