Patents by Inventor Stephanie Fesser

Stephanie Fesser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA MANUFACTURING
    Publication number: 20240110214
    Abstract: The present disclosure provides technologies for performing in vitro transcription that can generate product RNA preparations with reduced levels of certain contaminants (e.g., aberrant products), and particularly of double-stranded RNA (dsRNA).
    Type: Application
    Filed: December 7, 2021
    Publication date: April 4, 2024
    Inventors: Thomas Ziegenhals, Andreas Kuhn, Stephanie Fesser
  • 3'-UTR SEQUENCES FOR STABILIZATION OF RNA
    Publication number: 20230272406
    Abstract: The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3?-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.
    Type: Application
    Filed: September 28, 2022
    Publication date: August 31, 2023
    Inventors: Alexandra Orlandini Von Niessen, Stephanie Fesser, Britta Vallazza, Tim Beissert, Andreas Kuhn, Ugur Sahin, Marco Alexander Poleganov
  • IN VITRO TRANSCRIPTION TECHNOLOGIES
    Publication number: 20230183769
    Abstract: The present disclosure provides technologies for in vitro transcription reactions, particularly for production of pharmaceutical grade RNA, and in some embodiments for large scale production.
    Type: Application
    Filed: August 23, 2022
    Publication date: June 15, 2023
    Inventors: Irena Rabe, Maximilian Buff, Thomas Ziegenhals, Johanna Drögemüller, Andreas Kuhn, Stephanie Fesser, Rodney Gene Combs, Nicole Eschmann, Jennifer Ann Schoborg Romine, Jenna Kathryn Williamson
  • 3?-UTR sequences for stabilization of RNA
    Patent number: 11492628
    Abstract: The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3?-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: November 8, 2022
    Assignees: BioNTech SE, TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gGmbH
    Inventors: Alexandra Orlandini Von Niessen, Stephanie Fesser, Britta Vallazza, Tim Beissert, Andreas Kuhn, Ugur Sahin, Marco Alexander Poleganov
  • 5'-CAP-TRINUCLEOTIDE- OR HIGHER OLIGONUCLEOTIDE COMPOUNDS AND THEIR USE IN STABILIZING RNA, EXPRESSING PROTEINS IN THERAPY
    Publication number: 20210363172
    Abstract: The present invention relates to 5?-cap compounds, in particular the stabilization of RNA by such 5?-cap compounds, and provides compositions, such as pharmaceutical compositions, and cells comprising an RNA which is modified with such a 5?-cap compound, as well as methods for producing a peptide or protein of interest using the compositions or cells according to the present invention. Furthermore, the present invention provides the RNA, compositions, or cells for use in therapy, in particular for use in a method of treating a disease or disorder by protein replacement therapy, genome engineering, genetic reprogramming, and immunotherapy; a method for increasing the stability of RNA in cells; a method for increasing the expression of RNA in cells; and a method for providing an RNA with a 5?-cap structure.
    Type: Application
    Filed: March 14, 2019
    Publication date: November 25, 2021
    Inventors: Andreas Kuhn, Hiromi Muramatsu, Katalin Kariko, Stephanie Fesser, Ugur Sahin
  • 5'-CAP COMPOUNDS AND THEIR USES IN STABILIZING RNA, EXPRESSING PROTEINS AND IN THERAPY
    Publication number: 20210340170
    Abstract: The present invention relates to 5?-cap compounds, in particular the stabilization of RNA by such 5?-cap compounds, and provides compositions, such as pharmaceutical compositions, and cells comprising an RNA which is modified with such a 5?-cap compound, as well as methods for producing a peptide or protein of interest using the compositions or cells according to the present invention. Furthermore, the present invention provides the RNA, compositions, or cells for use in therapy, in particular for use in a method of treating a disease or disorder by protein replacement therapy, genome engineering, genetic reprogramming, and immunotherapy; a method for increasing the stability of RNA in cells; a method for increasing the expression of RNA in cells; and a method for providing an RNA with a 5?-cap structure.
    Type: Application
    Filed: July 9, 2021
    Publication date: November 4, 2021
    Inventors: Andreas Kuhn, Hiromi Muramatsu, Katalin Kariko, Stephanie Fesser, Ugur Sahin
  • 3'-UTR Sequences for Stabilization of RNA
    Publication number: 20190071682
    Abstract: The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3?-untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.
    Type: Application
    Filed: October 5, 2016
    Publication date: March 7, 2019
    Inventors: Alexandra Orlandini Von Niessen, Stephanie Fesser, Britta Vallazza, Tim Beissert, Andreas Kuhn, Ugur Sahin, Marco Alexander Poleganov