Patents by Inventor Stephanie Graf

Stephanie Graf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of and crystalline forms of optical enantiomers of modafinil
    Patent number: 9382200
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 8.54, 4.56, and 3.78 ?, and a process for the preparation thereof.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: July 5, 2016
    Assignee: Teva Sante
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stéphanie Graf, Gilles Serrure, Gérard Francois Coquerel, Sébastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
    Patent number: 8759583
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: June 24, 2014
    Assignee: Teva Sante
    Inventors: Laurent Courvoisier, Gerard Duret, Stephanie Graf, Laurence Prat-Lacondemine, Francois Rebiere, Nicolas Sabourault
  • Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
    Patent number: 8318979
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: November 27, 2012
    Assignee: Cephalon France
    Inventors: Laurent Courvoisier, Veronique Courvoisier, legal representative, Gerard Duret, Stephanie Graf, Laurence Prat-Lacondemine, Francois Rebiere, Nicolas Sabourault
  • Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation
    Publication number: 20120123161
    Abstract: The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). wherein n, Y, R1, R1a, R2 and R2a are as defined in claim 1.
    Type: Application
    Filed: March 24, 2011
    Publication date: May 17, 2012
    Applicant: CEPHALON FRANCE
    Inventors: Laurent Courvoisier, Veronique Courvoisier, Gerard Duret, Stephanie Graf, Laurence Prat-Lacondemine, Francois Rebiere, Nicolas Sabourault
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20100048718
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 5.23, 5.03, 4.22 and 4.10 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: February 25, 2010
    Applicant: Cephalon France
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gerard Francois Coquerel, Sebastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20100048720
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 14.14, 10.66, 7.80 and 4.02 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: February 25, 2010
    Applicant: Cephalon France
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stéphanie Graf, Gilles Serrure, Gérard Fransois Coquerel, Sébastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20100048719
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 12.31, 8.54, 7.27 and 3.62 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: February 25, 2010
    Applicant: Cephalon France
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gerard Francois Coquerel, Sebastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20100022653
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 8.54, 4.56, and 3.78 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: January 28, 2010
    Applicant: Cephalon France
    Inventors: Olivier NECKEBROCK, Laurent COURVOISIER, Stéphanie GRAF, Gilles SERRURE, Gérard Francois COQUEREL, Sébastien ROSE, Christine BESSELIEVRE, Franck Patrick MALLET, Adriaan Jan VAN LANGEVELDE
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20090281192
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 12.38, 8.58, 7.34, 5.00 and 4.09 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: November 12, 2009
    Applicant: Cephalon France
    Inventors: Olivier NECKEBROCK, Laurent COURVOISIER, Stéphanie GRAF, Gilles SERRURE, Gérard Francois COQUEREL, Sébastien ROSE, Christine BESSELIEVRE, Franck Patrick MALLET, Adriaan Jan VAN LAGEVELDE
  • Process for the Preparation of and Crystalline Forms of Optical Enantiomers of Modafinil
    Publication number: 20090281193
    Abstract: The invention relates to a polymorphic form of (?)-modafinil that produces a powder X-ray diffraction spectrum comprising intensity peaks corresponding to interplanar spacings of about 9.45, 7.15, 5.13, 4.15 and 3.67 ?, and a process for the preparation thereof.
    Type: Application
    Filed: July 22, 2009
    Publication date: November 12, 2009
    Applicant: Cephalon France
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gérard François Coquerel, Sébastien Rose, Christine Besselievre, Franck Patrick Mallet, Adriaan Jan Van Langevelde
  • Process for the preparation of and crystalline forms of optical enantiomers of modafinil
    Publication number: 20060241320
    Abstract: The invention relates to a process for the preparation of crystalline forms of the optical enantiomers of modafinil, comprising stages comprising: i) dissolving one of the optical enantiomers of modafinil in a solvent other than ethanol, ii) crystallising the modafinil enantiomer, iii) recovering the crystalline form of the modafinil enantiomer so obtained. The invention also relates to a process for the preparation of the optical enantiomers of modafinil.
    Type: Application
    Filed: June 26, 2006
    Publication date: October 26, 2006
    Applicants: Cephalon France, Organisation De Synthese Mondiale Orsymonde
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gerard Francois Coquerel, Sebastien Rose, Christine Besselievre, Franck Mallet, Adriaan Van Langevelde
  • Method for the production of crystalline forms and crystalline forms of optical enantiomers of modafinil
    Publication number: 20060135621
    Abstract: The invention relates to a process for the preparation of crystalline forms of the optical enantiomers of modafinil, comprising stages comprising: i) dissolving one of the optical enantiomers of modafinil in a solvent other than ethanol, ii) crystallising the modafinil enantiomer, iii) recovering the crystalline form of the modafinil enantiomer so obtained. The invention also relates to a process for the preparation of the optical enantiomers of modafinil.
    Type: Application
    Filed: December 18, 2003
    Publication date: June 22, 2006
    Applicants: Cephalon France, Organisation De Synthese Mondiale Orsymonde
    Inventors: Olivier Neckebrock, Laurent Courvoisier, Stephanie Graf, Gilles Serrure, Gerard Coquerel, Sebastien Rose, Christine Besselievre, Franck Mallet, Adriaan Van Langevelde