Patents by Inventor Stephanie H. I. Yeung

Stephanie H. I. Yeung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microfabricated integrated DNA analysis system
    Patent number: 8420318
    Abstract: Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of a sequencing template into a plurality of microfabricated thermal cycling chambers. A microreactor element may include a microcarrier element carrying the multiple copies of the sequencing template. The microcarrier element may comprise a microsphere. An autovalve at an exit port of a thermal cycling chamber, an optical scanner, or a timing arrangement may be used to ensure that only one microsphere will flow into one thermal cycling chamber wherein thermal cycling extension fragments are produced. The extension products are captured, purified, and concentrated in an integrated oligonucleotide gel capture chamber. A microfabricated component separation apparatus is used to analyze the purified extension fragments.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: April 16, 2013
    Assignee: The Regents of the University of California
    Inventors: Richard A. Mathies, Robert Blazej, Chung Liu, Palani Kumaresan, Stephanie H. I. Yeung
  • MICROFABRICATED INTEGRATED DNA ANALYSIS SYSTEM
    Publication number: 20120142010
    Abstract: Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of a sequencing template into a plurality of microfabricated thermal cycling chambers. A microreactor element may include a microcarrier element carrying the multiple copies of the sequencing template. The microcarrier element may comprise a microsphere. An autovalve at an exit port of a thermal cycling chamber, an optical scanner, or a timing arrangement may be used to ensure that only one microsphere will flow into one thermal cycling chamber wherein thermal cycling extension fragments are produced. The extension products are captured, purified, and concentrated in an integrated oligonucleotide gel capture chamber. A microfabricated component separation apparatus is used to analyze the purified extension fragments.
    Type: Application
    Filed: February 13, 2012
    Publication date: June 7, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Richard A. MATHIES, Robert BLAZEJ, Chung LIU, Palani KUMARESAN, Stephanie H.I. YEUNG
  • MICROFABRICATED INTEGRATED DNA ANALYSIS SYSTEM
    Publication number: 20110020920
    Abstract: Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of a sequencing template into a plurality of microfabricated thermal cycling chambers. A microreactor element may include a microcarrier element carrying the multiple copies of the sequencing template. The microcarrier element may comprise a microsphere. An autovalve at an exit port of a thermal cycling chamber, an optical scanner, or a timing arrangement may be used to ensure that only one microsphere will flow into one thermal cycling chamber wherein thermal cycling extension fragments are produced. The extension products are captured, purified, and concentrated in an integrated oligonucleotide gel capture chamber. A microfabricated component separation apparatus is used to analyze the purified extension fragments.
    Type: Application
    Filed: July 27, 2010
    Publication date: January 27, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Richard A. MATHIES, Robert BLAZEJ, Chung LIU, Palani KUMARESAN, Stephanie H. I. YEUNG
  • Microfabricated integrated DNA analysis system
    Patent number: 7799553
    Abstract: Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of a sequencing template into a plurality of microfabricated thermal cycling chambers. A microreactor element may include a microcarrier element carrying the multiple copies of the sequencing template. The microcarrier element may comprise a microsphere. An autovalve at an exit port of a thermal cycling chamber, an optical scanner, or a timing arrangement may be used to ensure that only one microsphere will flow into one thermal cycling chamber wherein thermal cycling extension fragments are produced. The extension products are captured, purified, and concentrated in an integrated oligonucleotide gel capture chamber. A microfabricated component separation apparatus is used to analyze the purified extension fragments.
    Type: Grant
    Filed: May 25, 2005
    Date of Patent: September 21, 2010
    Assignee: The Regents of the University of California
    Inventors: Richard A. Mathies, Robert Blazej, Chung Liu, Palani Kumaresan, Stephanie H. I. Yeung