Abstract: Disclosed herein include antibodies or fragments thereof having specificity to a sarbecovirus spike protein. Also provided are compositions, methods, and kits for using said antibodies or fragments thereof for preventing or treating, for example a coronavirus infection.

Abstract: A waveguide structure comprises a thin strip of material having a relatively high free charge carrier density surrounded by material having a relatively low free charge carrier density. The width and thickness of the strip are dimensioned such that optical radiation having a wavelength in a predetermined range couples to the strip and propagates along its length as a plasmon-polariton wave. The device includes a waveguide heater for passing a current through the strip to heat it and the surrounding material, so as to vary propagation of the optical radiation, or means for monitoring propagation of the optical radiation to determine a change in temperature of the strip. Some embodiments provide both heating of the strip and monitoring of its temperature.