Patents by Inventor Stephanie Kladakis
Stephanie Kladakis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10016454Abstract: A tissue sealant that includes the reaction product of (a) a polyol; (b) a polyisocyanate; and (c) an alkoxy silane having the formula: (R1R2R3)—Si—CH2—Z where (i) Z is an —OH, —SH, —NCO, or —NHR4 group, where R4 is hydrogen, an alkyl group, or an aryl group; and (ii) each R1, R2, and R3, independently, is H, an alkoxy group, an alkyl group, a heteroalkyl group other than an alkoxy group, an aryl group, or a heteroaryl group, with the proviso that at least two of R1, R2, and R3 are alkoxy groups, the relative amounts of the polyol, polyisocyanate, and alkoxy silane being selected such that the reaction product comprises free isocyanate groups. The tissue sealant is moisture-curable and biodegradable in a physiological environment.Type: GrantFiled: December 4, 2012Date of Patent: July 10, 2018Assignee: Cohera Medical, Inc.Inventors: Dottie Clower, Despina Dobbins, Stephanie Kladakis
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Publication number: 20140154204Abstract: A tissue sealant that includes the reaction product of (a) a polyol; (b) a polyisocyanate; and (c) an alkoxy silane having the formula: (R1R2R3)—Si—CH2—Z where (i) Z is an —OH, —SH, —NCO, or —NHR4 group, where R4 is hydrogen, an alkyl group, or an aryl group; and (ii) each R1, R2, and R3, independently, is H, an alkoxy group, an alkyl group, a heteroalkyl group other than an alkoxy group, an aryl group, or a heteroaryl group, with the proviso that at least two of R1, R2, and R3 are alkoxy groups, the relative amounts of the polyol, polyisocyanate, and alkoxy silane being selected such that the reaction product comprises free isocyanate groups. The tissue sealant is moisture-curable and biodegradable in a physiological environment.Type: ApplicationFiled: December 4, 2012Publication date: June 5, 2014Applicant: COHERA MEDICAL, INC.Inventors: Dottie Clower, Despina Dobbins, Stephanie Kladakis
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Publication number: 20080091234Abstract: Disclosed is an occluder for closing an intracardiac defect, such as a patent foramen ovale (PFO), and a method for making the same. The occluder includes a frame and at least one scaffold which are formed from a bioabsorbable polymer, such as poly-4-hydroxybutyrate. The surface of the frame and scaffold are textured to promote cell attachment. Texturing of the surface can be achieved by any number of mechanical or chemical procedures. The device is coated with collagen and heparin which are covalently bound to the surface of the device. The occluder provides improved defect closure compared to other septal occluders known in the art. In particular, the occluder described is specifically designed to improve host cell attachment to and tissue ingrowth over the device when implanted in a patient as compared to the level of host cell attachment and tissue ingrowth achieved with other implantable devices made of bioabsorbable polymers.Type: ApplicationFiled: September 26, 2007Publication date: April 17, 2008Inventor: Stephanie Kladakis
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Publication number: 20080077180Abstract: The present invention provides a device for occluding an anatomical aperture, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO). The occluder includes two sides connected by a central tube. A tissue scaffold material is disposed on the occluder. The occluder is formed from a tube, which is cut to produce struts in each side. Upon the application of force, the struts deform into loops. The loops may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. In some embodiments, at least one side of the occluder includes a tissue scaffold. The occluder further includes a catch system that maintains its deployed state in vivo. When the occluder is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture and the catch system is deployed so that the occluder exerts a compressive force on the septal tissue and closes the aperture.Type: ApplicationFiled: September 26, 2007Publication date: March 27, 2008Applicant: NMT Medical, Inc.Inventors: Stephanie Kladakis, David Marchesiello, Carol Devellian
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Publication number: 20070276415Abstract: Devices, delivery systems and delivery techniques for an occlusion device for the closure of physical anomalies, such as an atrial septal defect, a patent foramen ovale (PFO), and other septal and vascular defects are described. The devices, delivery systems and delivery techniques relate particularly to, but are not limited to, a patent foramen ovale (PFO) occluder made from a polymer tube, specifically, a petal-shaped occluder. In certain embodiments, the catch system includes a catch member with a screw catch mechanism for connecting to the occluder. A delivery system for use with the catch member includes a component for rotating the catch member relative to the occluder to engage the screw catch mechanism.Type: ApplicationFiled: March 28, 2007Publication date: November 29, 2007Applicant: NMT Medical, Inc.Inventors: Stephanie Kladakis, Ryan Cahill
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Publication number: 20070250115Abstract: Devices, delivery systems and delivery techniques for an occlusion device for the closure of physical anomalies, such as an atrial septal defect, a patent foramen ovale (PFO), and other septal and vascular defects are described. The devices, delivery systems and delivery techniques relate particularly to, but are not limited to, a patent foramen ovale (PFO) occluder made from a polymer tube. In certain embodiments, the occluder includes a catch system that holds the occluder in the deployed, expanded profile. The catch system includes a locking funnel cap. In some embodiments, the locking funnel cap forces the proximal ends of the occluder in a radially inward position to lock the catch member in place and prevent the occluder from moving from its deployed configuration.Type: ApplicationFiled: March 27, 2007Publication date: October 25, 2007Applicant: NMT Medical, Inc.Inventors: Steven Opolski, Stephanie Kladakis, Ryan Cahill
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Publication number: 20070179474Abstract: This invention relates to a syringe-activated valve for flushing a catheter for delivering an implant to an anatomical site, such as a patent foramen ovale in a patient and method thereof. In one embodiment, a catheter includes a proximal end, a distal end, a “Y” connector at the proximal end, the “Y” connector having a guide wire port and a connector port, a syringe activated valve having a first end and a second end, the second end of syringe-activated valve connecting to the connector port of the “Y” connector, and a syringe connecting to the first end of the syringe-activated valve. Saline is injected by the syringe through the syringe-activated valve into the proximal end of the catheter, thereby flushing air from the catheter lumen out of the distal end of the catheter.Type: ApplicationFiled: December 28, 2006Publication date: August 2, 2007Inventors: Ryan Cahill, Stephanie Kladakis
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Publication number: 20070167981Abstract: Devices and techniques for modifying and maintaining a configuration of an occlusion device for the closure of physical anomalies, such as an atrial septal defect, a patent foramen ovale (PFO), and other septal and vascular defects are described. The devices and techniques relate particularly to, but are not limited to, modifying and maintaining a configuration of a PFO occluder made from a polymer tube. The proximal portion of a catch member may be provided with one or more protrusions, or arms, or bump or other raised element for securing the occluder in a partial or fully deployed configuration, either temporarily or permanently.Type: ApplicationFiled: December 21, 2006Publication date: July 19, 2007Applicant: NMT Medical, Inc.Inventors: Steven Opolski, Sean Forde, Stephanie Kladakis, David Callaghan
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Publication number: 20070118176Abstract: The present invention provides an occluder for a biological defect, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO). The occluder is at least partially formed of a radiopaque, bioabsorbable material. In some embodiments, the occluder is formed from a tube, which is cut to produce struts in each side. Upon the application of force, the struts deform into loops. The radiopaque, bioabsorbable material is a blend of a biocompatible radiopaque material with a bioabsorbable material. In some embodiments, the radiopaque material may have a mass attenuation coefficient greater than about 1.2 cm2/gm and/or a linear attenuation coefficient greater than about 9 cm?1. In some embodiments, the radiopaque material is tungsten. In some embodiments, the bioabsorbable material may have a molecular weight greater than about 300,000. In some embodiments, the bioabsorbable material is a polymer.Type: ApplicationFiled: October 24, 2006Publication date: May 24, 2007Inventors: Steven Opolski, Stephanie Kladakis
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Publication number: 20070055229Abstract: The present invention provides methods and devices for sealing intracardiac defects, such as a patent foramen ovale (PFO) utilizing an electrode positioned in the lumen of the defect such as the tunnel of a PFO.Type: ApplicationFiled: September 6, 2006Publication date: March 8, 2007Inventors: Stephanie Kladakis, James Scutti, Carol Devellian, Helen Liu
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Publication number: 20070031470Abstract: A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.Type: ApplicationFiled: June 29, 2006Publication date: February 8, 2007Applicant: DEPUY MITEK, INC.Inventors: Stephanie Kladakis, Joseph Hammer, Shetty Dhanuraj, Sridevi Dhanaraj, Mark Timmer
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Publication number: 20060280768Abstract: Methods and apparatus for treating meniscal tissue damage are disclosed, including a biocompatible meniscal repair device comprising a stent. The tissue repair device is adapted to be placed in contact with a defect in the meniscus and can preferably provide a structure for supporting meniscal tissue and/or encouraging tissue growth through contact with vascularized portions of the meniscus or as a conduit for introduction of exogenous healing therapies.Type: ApplicationFiled: June 13, 2005Publication date: December 14, 2006Inventors: Julia Hwang, Stephanie Kladakis, Sudhakar Kadiyala, Steven Bowman
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Publication number: 20050234549Abstract: Methods and apparatus for treating meniscal tissue damage are disclosed, including a biocompatible meniscal repair device comprising a biocompatible tissue repair scaffold and a cell growth conduit flap. The tissue repair scaffold is adapted to be placed in contact with a defect in the meniscus and can preferably provide a structure for supporting meniscal tissue and/or encouraging tissue growth. The cell growth conduit flap, which is attached to the tissue repair scaffold, allows communication between the synovium and the tissue repair scaffold.Type: ApplicationFiled: April 20, 2004Publication date: October 20, 2005Inventors: Stephanie Kladakis, Steven Bowman, Robert Steckel
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Publication number: 20050232967Abstract: A biocompatible meniscal repair device is disclosed. The tissue repair device includes a scaffold adapted to be placed in contact with a defect in a meniscus, the scaffold comprising a high-density, dry laid nonwoven polymeric material and a biocompatible foam. The scaffold provides increased suture pull-out strength.Type: ApplicationFiled: April 20, 2004Publication date: October 20, 2005Inventors: Stephanie Kladakis, Joseph Hammer, Dhanuraj Shetty, Sridevi Dhanaraj
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Publication number: 20050177249Abstract: A composite implant is provided for repairing a tissue defect in a patient. In one embodiment, the implant is a porous tissue scaffold having at least one pocket formed therein and adapted to contain a viable tissue. The tissue scaffold can have a variety of configurations, and in one embodiment it includes top and bottom portions that can be at least partially mated to one another, and in an exemplary embodiment that are heated sealed to one another around a perimeter thereof to form an enclosed pocket therebetween. The pocket is preferably sealed with a viable tissue disposed therein. In another embodiment, the tissue scaffold is substantially wedge-shaped and the pocket comprises a hollow interior formed in the tissue scaffold, and/or at least one lumen extending into the tissue scaffold. The tissue scaffold can also optionally include at least one surface feature formed thereof to promote blood vessel formation.Type: ApplicationFiled: February 9, 2004Publication date: August 11, 2005Inventors: Stephanie Kladakis, Sridevi Dhanaraj, Robert Boock
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Publication number: 20050125077Abstract: Biocompatible tissue implants are provided for repairing a tissue injury or defect. The tissue implants comprise a biological tissue slice that serves as a source of viable cells capable of tissue regeneration and/or repair. The biological tissue slice can be harvested from healthy tissue to have a geometry that is suitable for implantation at the site of the injury or defect. The harvested tissue slice is dimensioned to allow the viable cells contained within the tissue slice to migrate out and proliferate and integrate with tissue surrounding the injury or defect site. Methods for repairing a tissue injury or defect using the tissue implants are also provided.Type: ApplicationFiled: December 5, 2003Publication date: June 9, 2005Inventors: Alexander Harmon, Stephanie Kladakis, Julia Hwang