Patents by Inventor Stephanie Konen-Waisman

Stephanie Konen-Waisman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptides used as carriers in immunogenic constructs suitable for development of synthetic vaccines
    Patent number: 5869058
    Abstract: The invention relates to conjugates of poorly immunogenic antigens, e.g., peptides, proteins and polysaccharides, with a synthetic peptide carrier constituting a T cell epitope derived from the sequence of E. coli hsp65 (GroEL), or an analog thereof, said peptide or analog being capable of increasing substantially the immunogenicity of the poorly immunogenic antigen. A suitable peptide according to the invention is Pep278e, which corresponds to positions 437-453 of the E. coli hsp65 molecule.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: February 9, 1999
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Irun R. Cohen, Matityahu Fridkin, Stephanie Konen-Waisman
  • Conjugates of poorly immunogenic antigens and synthetic peptide carriers and vaccines comprising them
    Patent number: 5736146
    Abstract: The invention relates to conjugates of poorly immunogenic antigens, e.g. peptides, proteins and polysaccharides, with a synthetic peptide carrier constituting a T cell epitope derived from the sequence of human heat shock protein hsp65, or an analog thereof, said peptide or analog being capable of increasing substantially the immunogenicity of the poorly immunogenic antigen. Suitable peptides according to the invention are Pep278h, which corresponds to positions 458-474 of human hsp65, and Pep II, which corresponds to positions 437-448 of human hsp65, but in which two cysteine residues at positions 442 and 447 are replaced serine residues.
    Type: Grant
    Filed: February 22, 1995
    Date of Patent: April 7, 1998
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Irun R. Cohen, Matityahu Fridkin, Stephanie Konen-Waisman