Abstract: Implantable medical systems that include an implantable medical lead coupled to an implantable medical device for purposes of electrical stimulation therapy and/or sensing of physiological signals includes at least one twisted pair of conductors within the implantable medical lead. The twisted pair corresponds to a stimulation or sensing channel of the implantable medical device. The twisted pair provides attenuation of electromagnetic interference noise that is present at the lead or lead extension. The twisted pair may be present in a lumen of the implantable medical lead or encapsulated by the lead body. The twisted pair, along with any other conductors of the lead, may be of a linear configuration or may be coiled.