Abstract: The present invention refers to a mutein of the ?-subunit of human Interleukin 27 and of human heterodimeric Interleukin 27 according to the present invention. The present invention further refers to a nucleic acid molecule comprising a nucleotide sequence encoding a mutein of the ?-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27. The invention further refers to a host cell containing a nucleic acid molecule comprising a nucleotide sequence encoding a mutein of the ?-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27. The invention also refers to an immune modulator comprising a mutein of the ?-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27, to the respective use thereof as well as to a method of producing a said muteins.

Abstract: The present application relates to a method and a device for preoperatively predicting a postoperative horizontal depth of an intraocular lens in a patient's eye. Parameter values are provided, said parameters including a first parameter as the depth of an anterior chamber of human eyes, a second parameter as a horizontal length of human eyes, and a third parameter as a postoperative position of intraocular lenses in human eyes. Specific triplets of values are selected from said values as main interpolation nodes, each triplet of values comprising a value for each of the three aforementioned parameters, and the main interpolation nodes are entered into a three-dimensional coordinate system that is spanned by the three parameters.

Abstract: The present invention relates to a system of artificial intelligence for the classification of events, objects or situations from signals and discriminant parameters produced by models comprising at least one processing branch comprising a fuzzy expert system making a decision according to high level properties and discriminant parameters of low level extracted from signals by signal processing type procedures, and capable of explaining its decision to the user through the intermediary of rules selected by order of applicability.