Abstract: The invention provides a compound of formula (I), or pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, wherein R1 is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered aromatic heterocycle; and R2 is an optionally substituted 5- or 6-membered aromatic heterocycle. Also provided are pharmaceutical compositions comprising a compound of formula (I).

Abstract: An environmental-efficiency fluid is designed by a system and/or method. The fluid can be for use in a down-hole operation in a well. The design produces the environmental-efficiency fluid from a treatment fluid and drill cuttings. For example, the system and method can include creating an analysis of a rheological model generated from a set of wellbore conditions and a set of drill-cutting properties to determine a set of rheological properties for the treatment fluid and a concentration of drill cuttings, which allow for use of the drill cuttings with the treatment fluid; and producing the environmental-efficiency fluid based on the rheological properties and the concentration of drill cuttings.