Abstract: An intraocular lens is provided which includes a single optical part, a haptic element, which is coupled to the optical part, and an optical main axis, which penetrates a front face and a rear face of the optical part, the haptic element having a first haptic part, which is in the form of a first ring and extends around the optical part, and at least one second haptic part, which is in the form of a second ring and extends around the optical part and is elastically movable relative to the first haptic part, at least one of the two rings being uneven in the peripheral direction about the optical main axis, at least one of the two rings having exactly two ring valleys and exactly two ring hills.

Abstract: An intraocular lens is provided which includes an optical part and a haptic, which is coupled to the optical part, and with a main optical axis, which intersects a front side and a rear side of the optical part, wherein the haptic has at least one first haptic part, which is configured as a strand-like clip, wherein the strand-like clip has a longitudinal axis, wherein the strand-like clip has at least one length-changing apparatus with which the strand-like clip is variable in its length in a defined manner in the direction of its longitudinal axis.

Abstract: An intraocular lens is provided which includes a single optical part, a haptic element, which is coupled to the optical part, and an optical main axis, which penetrates a front face and a rear face of the optical part, the haptic element having a first haptic part, which is in the form of a first ring and extends around the optical part, and at least one second haptic part, which is in the form of a second ring and extends around the optical part and is elastically movable relative to the first haptic part, at least one of the two rings being uneven in the peripheral direction about the optical main axis, at least one of the two rings having exactly two ring valleys and exactly two ring hills.

Abstract: The present invention refers to a secretion-competent mutein of the ?-subunit of human Interleukin 27 and to a human heterodimeric Interleukin 27. The present invention further refers to a nucleic acid molecule comprising a nucleotide sequence encoding a secretion-competent mutein of the ?-subunit of human Interleukin 27 or the human heterodimeric Interleukin 27, to a host cell containing a nucleic acid molecule comprising a nucleotide sequence encoding a secretion-competent mutein of the ?-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27. The invention also refers to an immune modulator comprising a secretion-competent mutein of the ?-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27, to the respective use thereof as well as to a method of producing said secretion-competent muteins and to a secretion-incompetent mutein of the ?-subunit of mouse Interleukin 27 and a secretion-competent mutein of the ?-subunit of mouse Interleukin 27.

Abstract: Lithographic printing plate precursors are prepared with a unique aluminum-containing substrate and one or more radiation-sensitive imageable layers. The aluminum-containing substrate is prepared by three separate and sequential anodizing processes to provide an inner aluminum oxide layer having an average dry thickness (Ti) of 500-1,500 nm and a multiplicity of inner pores having an average inner pore diameter (Di) larger than 0 and <15 nm. A formed middle aluminum oxide layer has a dry thickness (Tm) of 60-300 nm and a multiplicity of middle pores of average middle pore diameter (Dm) of 15-60 nm, arranged over the inner aluminum oxide layer. A formed outer aluminum oxide layer comprises a multiplicity of outer pores having an average outer pore diameter (Do) of 5-35 nm and an average dry thickness (To) of 30-150 nm, arranged over the middle aluminum oxide layer. Dm is larger than Do that is larger than Di.

Abstract: Lithographic printing plate precursors are prepared with a unique aluminum-containing substrate and one or more radiation-sensitive imageable layers. The aluminum-containing substrate is prepared by three separate and sequential anodizing processes to provide an inner aluminum oxide layer having an average dry thickness (Ti) of 500-1,500 nm and a multiplicity of inner pores having an average inner pore diameter (Di) larger than 0 and <15 nm. A formed middle aluminum oxide layer has a dry thickness (Tm) of 60-300 nm and a multiplicity of middle pores of average middle pore diameter (Dm) of 15-60 nm, arranged over the inner aluminum oxide layer. A formed outer aluminum oxide layer comprises a multiplicity of outer pores having an average outer pore diameter (Do) of 5-35 nm and an average dry thickness (To) of 30-150 nm, arranged over the middle aluminum oxide layer. Dm is larger than Do that is larger than Di.

Abstract: The present invention refers to a secretion-competent mutein of the ?-subunit of human Interleukin 27 and to a human heterodimeric Interleukin 27. The present invention further refers to a nucleic acid molecule comprising a nucleotide sequence encoding a secretion-competent mutein of the ?-subunit of human Interleukin 27 or the human heterodimeric Interleukin 27, to a host cell containing a nucleic acid molecule comprising a nucleotide sequence encoding a secretion-competent mutein of the ?-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27. The invention also refers to an immune modulator comprising a secretion-competent mutein of the ?-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27, to the respective use thereof as well as to a method of producing said secretion-competent muteins and to a secretion-incompetent mutein of the ?-subunit of mouse Interleukin 27 and a secretion-competent mutein of the ?-subunit of mouse Interleukin 27.

Abstract: Herein is reported a method for producing of a polypeptide conjugated to one poly (ethylene glycol) comprising a) providing a nucleic acid encoding an expression construct comprising in 5? to 3? direction a nucleic acid encoding a polypeptide, and a nucleic acid encoding a trypsin site of SEQ ID NO: 01, b) expressing the nucleic acid of a) in a cell and recovering the expression construct from the cell and/or the cultivation medium, c) providing a target peptide with man amino acid sequence of SEQ ID NO: 02 covalently conjugated to a poly (ethylene glycol) at the C-terminal lysine residue, d) incubating the expression construct and the target peptide with the trypsin mutant D189K, K60E, N143H, E151H, and e) recovering and thereby producing the polypeptide conjugated to one poly (ethylene glycol) from the incubation mixture.

Abstract: Herein is reported a method for producing of a polypeptide conjugated to one poly (ethylene glycol) comprising a) providing a nucleic acid encoding an expression construct comprising in 5? to 3? direction a nucleic acid encoding a polypeptide, and a nucleic acid encoding a trypsin site of SEQ ID NO: 01, b) expressing the nucleic acid of a) in a cell and recovering the expression construct from the cell and/or the cultivation medium, c) providing a target peptide with an amino acid sequence of SEQ ID NO: 02 covalently conjugated to a poly (ethylene glycol) at the C-terminal lysine residue, d) incubating the expression construct and the target peptide with the trypsin mutant D189K, K60E, N143H, E151H, and e) recovering and thereby producing the polypeptide conjugated to one poly (ethylene glycol) from the incubation mixture.

Abstract: Herein is reported a method for producing of a polypeptide conjugated to one poly (ethylene glycol) comprising a) providing a nucleic acid encoding an expression construct comprising in 5? to 3? direction a nucleic acid encoding a polypeptide, and a nucleic acid encoding a trypsin site of SEQ ID NO: 01, b) expressing the nucleic acid of a) in a cell and recovering the expression construct from the cell and/or the cultivation medium, c) providing a target peptide with an amino acid sequence of SEQ ID NO: 02 covalently conjugated to a poly (ethylene glycol) at the C-terminal lysine residue, d) incubating the expression construct and the target peptide with the trypsin mutant D189K, K60E, N143H, E151H, and e) recovering and thereby producing the polypeptide conjugated to one poly (ethylene glycol) from the incubation mixture.