Abstract: The present invention relates to the use of mavoglurant in the treatment of gambling disorder. The present invention also relates to the use of mavoglurant in the treatment of gaming disorder.

Abstract: Described herein is a crucible with a rod fused thereon to optimize pouring of molten material, and method of using the same. The crucible has a body configured for receipt of an amorphous alloy material in a vertical direction, and the rod extends in a horizontal direction from the body. The body of the crucible and the rod are formed from silica or quartz. The rod may be fused to the body of the crucible and provided off a center axis so that pouring molten material is improved when the crucible is rotated.

Abstract: Laminate BMG-fiber feedstock and parts made from one or more fiber layers and two or more bulk metallic glass (BMG) layers are described herein. The hot formed BMG-fiber laminates have vastly superior strength, ductility and use parameters as compared to the fiber or BMG alone as well as to conventional metal-fiber weaves. Methods of formation for both the BMG-fiber laminate and for near-to-net parts made therefrom are also provided.

Abstract: An aminoacylation/translation (AIT) system based on the protein synthesis system from the pathogen Pseudomonas aeruginosa, was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: EF-Tu, EF-Ts and EF-G, aminoacyl tRNA synthetase (aaRS) specific for phenylalanine, PheRS, and ribosomes isolated from cultures of Pseudomonas aeruginosa. Compounds identified using this assay have been shown to contain broad spectrum activity against both Gram+ and Gram? pathogens. Methods of using the identified compounds, as well as derivatives and analogues of these compounds, as antimicrobial agents against bacterial infections are described.

Abstract: An aminoacylation/translation (AIT) system based on the protein synthesis system from the pathogen Pseudomonas aeruginosa, was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: EF-Tu, EF-Ts and EF-G, aminoacyl tRNA synthetase (aaRS) specific for phenylalanine, PheRS, and ribosomes isolated from cultures of Pseudomonas aeruginosa. Compounds identified using this assay have been shown to contain broad spectrum activity against both Gram+ and Gram? pathogens. Methods of using the identified compounds, as well as derivatives and analogues of these compounds, as antimicrobial agents against bacterial infections are described.

Abstract: Described herein is a crucible with a rod fused thereon to optimize pouring of molten material, and method of using the same. The crucible has a body configured for receipt of an amorphous alloy material in a vertical direction, and the rod extends in a horizontal direction from the body. The body of the crucible and the rod are formed from silica or quartz. The rod may be fused to the body of the crucible and provided off a center axis so that pouring molten material is improved when the crucible is rotated.

Abstract: Described herein is a method of forming a 3D investment mold using a layer-by-layer construction (3D printing). The mold is configured for receipt of a molten alloy having a composition configured to form a bulk metallic glass (BMG) on cooling. The mold has a hollow interior between inner and outer walls. The hollow interior receives the molten alloy for molding it between the inner and outer walls of the mold. A method of casting using the 3D investment mold is also disclosed, which may include filling the mold with molten alloy, removing bubbles, quenching the molten alloy in the mold, and then removing the mold.

Abstract: Described herein is an injection molding or die casting machine having an ultrasonic vibration generator associated therewith that is configured to apply ultrasonic vibrations during melting and/or injection of the molten material (e.g., molten alloy). The ultrasonic vibrations may be applied to molten material via the plunger tip of the plunger in the machine, and/or the mold and/or the vessel, for example. The ultrasonic vibration may be applied during plunger tip movement so that the molten material vibrates ultrasonically during melting and injection. A connector may be connected to the ultrasonic vibration generator and the plunger. Channels may be provided in the plunger tip and/or vessel to accommodate a cooling fluid during melting and injection.

Abstract: Nicotine dependency is treated by administration of an opioid antagonist. In some embodiments, rapid or ultra rapid detoxification techniques include using a combination of an effective amount of an opioid antagonist such as nalmefene, naloxone or naltrexone or a mixture of any one of these, and either clonidine or related compounds either while awake, or while under sedation or anesthesia, followed by continued administration of an effective amount of an opioid antagonist with or without agents that enhance nicotine dependency treatment.

Abstract: Nicotine dependency is treated by administration of an opioid antagonist. In some embodiments, rapid or ultra rapid detoxification techniques include using a combination of an effective amount of an opioid antagonist such as nalmefene, naloxone or naltrexone or a mixture of any one of these, and either clonidine or related compounds either while awake, or while under sedation or anesthesia, followed by continued administration of an effective amount of an opioid antagonist with or without agents that enhance nicotine dependency treatment.