Abstract: Described herein are variant adeno-associated virus (AAV) capsid polypeptides and gene therapeutics thereof for use in the treatment or prevention of hearing loss.

Abstract: Described herein are variant adeno-associated virus (AAV) capsid polypeptides and gene therapeutics thereof for use in the treatment or prevention of hearing loss.

Abstract: Provided herein are methods for preventing and/or reducing the severity of drug induced ototoxicity. Provided herein are methods for recovery from hearing loss due to drug-induced ototoxicity.

Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with a non-natural neurotrophic agent compositions and formulations administered to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

Abstract: Because ice-I is less dense than water, the formation of an ice nucleus in an isochoric (constant volume) system containing water at pressures lower than about 200 MPa will cause an increase in pressure. This increase in pressure increases the energy required for reducing the probability for ice nucleation in an isochoric system containing water. In the present invention, a system for decreasing the probability of ice nucleation in a system containing water based on isochoric cooling and warming is provided. Reduction in the probability of ice nucleation has use in biological material preservation at low temperatures in: a supercooled state, by rapid freezing and through vitrification.